1. Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity
- Author
-
Anting Liu Carlsen, Karen R. Wøjdemann, Line Rode, Paula L. Hedley, Jennifer M. Jørgensen, Ann Tabor, A. Gjerris, Sophie Placing, Michael Christiansen, Karin Sundberg, and A. C. Shalmi
- Subjects
Pregnancy ,medicine.medical_specialty ,business.industry ,Obstetrics ,Birth weight ,Obstetrics and Gynecology ,Gestational age ,medicine.disease ,Preeclampsia ,medicine.anatomical_structure ,Insulin resistance ,Placenta ,Internal Medicine ,medicine ,Resistin ,business ,Body mass index - Abstract
Objective: To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). Methods: A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and maternal age. Samples were taken in gestational weeks 10+0–13+6. Results: There was a negative correlation between resistin and clinical severity of PE, but no correlation with IS, TNF-α, body mass index, birth weight and pregnancy length. Conclusions: Resistin is reduced in first trimester of PE pregnancies, particularly in severe PE. Inflammation and IS cannot explain this phenomenon.
- Published
- 2015
- Full Text
- View/download PDF