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This systematic review synthesizes findings from 19 empirical studies published between 1970 and 2014 that examine the relationship between job burnout and affective, psychological, physiological, and behavioral well-being among human service workers. Study findings point to the detrimental impact of job burnout on the well-being of workers. Studies in this area of research continue to use the Maslach Burnout Inventory as the primary measure of burnout, are largely cross-sectional in design, and focus mostly on affective well-being as an outcome. A discussion on the impact of study findings for human service workforce management and future research is presented. [ABSTRACT FROM PUBLISHER]