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Start Over Author "Bonde, J" Journal human reproduction
19 results on '"Bonde, J"'

6. Birth weight for gestational age and the risk of infertility: a Danish cohort study.

Author

Thorsted, A, Lauridsen, J, Høyer, B, Arendt, L H, Bech, B, Toft, G, Hougaard, K, Olsen, J, Bonde, J P, and Ramlau-Hansen, C

Subjects
BIRTH weight, GESTATIONAL age, CRYPTORCHISM, INFERTILITY, MALE infertility, COHORT analysis, LOGISTIC regression analysis, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, LONGITUDINAL method
Abstract

Study Question: Is birth weight for gestational age associated with infertility in adulthood among men and women?Summary Answer: Being born small for gestational age (SGA) was associated with infertility in adulthood among men.What Is Known Already: Fetal growth restriction may affect fertility, but results from previous studies have been inconsistent.Study Design, Size, Duration: In this population-based cohort study, we used data from a Danish birth cohort, including 5594 men and 5342 women born between 1984 and 1987. Information on infertility was obtained from Danish health registers during the period from the participants' 18th birthday and up until 31 December 2017.Participants/materials, Setting, Methods: Participants were men and women born in two Danish municipalities, Aalborg and Odense. Information on birth weight and gestational age was obtained from birth records, and information on infertility diagnoses and fertility treatment was retrieved from the Danish National Patient Registry (NPR) and the Danish In Vitro Fertilisation (IVF) registry. Information on potential maternal confounders was obtained from questionnaires during pregnancy and was included in adjusted analyses. Logistic regression analysis was used to estimate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for infertility according to birth weight for gestational age.Main Results and the Role Of Chance: Men born SGA had a 55% higher risk of being diagnosed with or treated for infertility compared to men born appropriate for gestational age (AGA) (adjusted OR = 1.55, 95% CI: 1.09-2.21). The association attenuated after exclusion of men born with hypospadias or cryptorchidism (OR = 1.37, 95% CI: 0.93-2.01). No association was found between women's birth weight for gestational age and risk of infertility (adjusted OR = 1.00, 95% CI: 0.73-1.37).Limitations, Reasons For Caution: Estimation of gestational age is associated with some uncertainty and might have caused non-differential misclassification. The study design implicitly assumed similar distribution of reproductive and health-seeking behaviour across the groups that were compared.Wider Implications Of the Findings: Men born SGA had a higher risk of infertility. Genital malformations may account for part of the observed association, but this must be explored further.Study Funding/competing Interest(s): This study was supported by Health, Aarhus University. No competing interests are declared.Trial Registration Number: N/A. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Spontaneous abortion in IVF couples—a role of male welding exposure

Author

Hjollund, N H, Bonde, J P, Ernst, E, Lindenberg, S, Andersen, A N, Olsen, J, and Hjøllund, Niels Henrik Ingvar

Subjects
Adult, Chromium, Male, Questionnaires, medicine.medical_specialty, Denmark, medicine.medical_treatment, Fertilization in Vitro, Welding, Abortion, law.invention, Pregnancy, Risk Factors, law, Surveys and Questionnaires, Occupational Exposure, Animals, Humans, Medicine, Registries, reproductive and urinary physiology, Gynecology, In vitro fertilisation, business.industry, Proportional hazards model, Rehabilitation, technology, industry, and agriculture, Obstetrics and Gynecology, Stainless Steel, medicine.disease, Abortion, Spontaneous, Paternal Exposure, Increased risk, Reproductive Medicine, Relative risk, Female, business
Abstract

Background Fume from welding of stainless steel contains hexavalent chromium, which in animal studies can induce paternally mediated spontaneous abortion. Human studies have shown conflicting results. The best studies include early pregnancy experience, but these are expensive to conduct. In vitro fertilization (IVF) provides new design opportunities. Our aim was to study pregnancy survival in IVF treated women with respect to paternal welding exposure. Methods We mailed a questionnaire to 5879 couples from the Danish IVF register that covers all IVF treatments after 1993 (response ratio 68.2%). A subgroup of male metal workers received a second questionnaire on exposure to welding (n = 319 men, response ratio 77%). Information on outcome was collected from national health registers. Survival of the first hCG-positive pregnancy was analysed using Cox regression. Results The proportion of pregnancies terminated by spontaneous abortion before 28 gestational weeks was 18% (n = 91 pregnancies) and 25% (n = 128) in pregnancies with paternal exposure to stainless steel welding and mild steel welding, respectively. In the reference group of 2925 pregnancies the abortion ratio was 28%. The risk ratio for pregnancies with paternal exposure to stainless steel was 0.6 (95% CI 0.4-1.0). Conclusions We found no increased risk of spontaneous abortion in IVF treated women, who became pregnant by a man exposed to welding of any sort. Since the process of fertilization and selection of IVF pregnancies differs from natural pregnancies the negative results need not apply to other pregnancies.

Published
2005

8. No association between body mass index and sperm DNA integrity

Author

Bandel, I., primary, Bungum, M., additional, Richtoff, J., additional, Malm, J., additional, Axelsson, J., additional, Pedersen, H. S., additional, Ludwicki, J. K., additional, Czaja, K., additional, Hernik, A., additional, Toft, G., additional, Bonde, J. P., additional, Spano, M., additional, Malm, G., additional, Haugen, T. B., additional, and Giwercman, A., additional

Published
2015
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9. Indices of methylation in sperm DNA from fertile men differ between distinct geographical regions

Author

Consales, C., primary, Leter, G., additional, Bonde, J. P. E., additional, Toft, G., additional, Eleuteri, P., additional, Moccia, T., additional, Budillon, A., additional, Jonsson, B. A. G., additional, Giwercman, A., additional, Pedersen, H. S., additional, Ludwicki, J. K., additional, Zviezdai, V., additional, Heederik, D., additional, and Spano, M., additional

Published
2014
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12. Andrology (Male Fertility, Spermatogenesis)

Author

Matsumoto, Y., primary, Goto, S., additional, Hashimoto, H., additional, Kokeguchi, S., additional, Shiotani, M., additional, Okada, H., additional, Cohen - Bacrie, P., additional, Hazout, A., additional, Belloc, S., additional, De Mouzon, J., additional, Menezo, Y., additional, Dumont, M., additional, Junca, A. M., additional, Cohen-Bacrie, M., additional, Alvarez, S., additional, Olivennes, F., additional, Prisant, N., additional, Weltin, M., additional, Geissler, W., additional, Clussmann, C., additional, Strowitzki, T., additional, Eggert-Kruse, W., additional, Endou, Y., additional, Fjii, Y., additional, Motoyama, H., additional, Quintana, F. Q., additional, Zaloa Larreategui, Z. L., additional, Iratxe Penalba, I. P., additional, Sara Ortega, S. O., additional, Monica Martin, M. M., additional, Guillermo Quea, G. Q., additional, Jose Serna, J. S., additional, Showell, M. G., additional, Brown, J., additional, Yazdani, A., additional, Stankiewicz, M. T., additional, Hart, R. J., additional, Zumoffen, C., additional, Munuce, M. J., additional, Caille, A., additional, Ghersevich, S., additional, Lendinez, A. M., additional, Perez-Nevot, B., additional, Palomares, A. R., additional, Serrano Garballo, A., additional, Rodriguez, A., additional, Reche, A., additional, Mayor-Olea, A., additional, Ruiz-Galdon, M., additional, Reyes-Engel, A., additional, Mendiola, J., additional, Jorgensen, N., additional, Andersson, A. M., additional, Calafat, A. M., additional, Redmon, J. B., additional, Drobnis, E. Z., additional, Wang, C., additional, Sparks, A., additional, Thurston, S. W., additional, Liu, F., additional, Swan, S. H., additional, Tarasconi, A. C., additional, Tarasconi, B. V., additional, Tarasconi, D. V., additional, Silva, E. M. V., additional, Fujii, Y., additional, Crha, I., additional, Pribyl, J., additional, Skladal, P., additional, Zakova, J., additional, Ventruba, P., additional, Pohanka, M., additional, De La Fuente, G., additional, Pacheco, A., additional, Velasco, J. A. G., additional, Requena, A., additional, Pacheco Castro, A., additional, San Celestino Carchenilla, M., additional, Salvanes, R., additional, Arnanz, A., additional, Balmori, C., additional, Pellicer, A., additional, Garcia-Velasco, J. A., additional, Ishikawa, T., additional, Fujisawa, M., additional, Kranz, S., additional, Hersemeyer, K., additional, Hentrich, A., additional, Tinneberg, H. R., additional, Konrad, L., additional, Simon, L., additional, Lutton, D., additional, McManus, J., additional, Lewis, S. E. M., additional, Rubio, S., additional, Simon Sanjurjo, P., additional, Lewis, S., additional, Buzzi, J., additional, Valcarcel, A., additional, Lombardi, E., additional, Oses, R., additional, Rawe, V., additional, Young, E., additional, Magendzo, A., additional, Lizama, S., additional, Duque, G., additional, Mackenna, A., additional, Monqaut, A., additional, Zavaleta, C., additional, Lopez, G., additional, Lafuente, R., additional, Brassesco, M., additional, Condorelli, R., additional, La Vignera, S., additional, La Rosa, S., additional, Barone, N., additional, Vicari, E., additional, Bellanca, S., additional, D'Agata, R., additional, Calogero, A. E., additional, Enciso, M., additional, Iglesias, M., additional, Galan, I., additional, Gosalvez, A., additional, Gosalvez, J., additional, Curaba, M., additional, Poels, J., additional, Van Langendonckt, A., additional, Donnez, J., additional, Wyns, C., additional, Garcez, M., additional, Salvador, M., additional, Pasqualotto, E. B., additional, Braga, D. P. A. F., additional, Borges, E., additional, Pasqualotto, F. F., additional, Aoki, T., additional, Figueira, R. C. S., additional, Maldonado, L. G. L., additional, Iaconelli, A., additional, Frassini, R., additional, Mandelli, J., additional, Setti, A. S., additional, Cortezzi, S. S., additional, Di Mauro, M., additional, Burrello, N., additional, Kashir, J., additional, Jones, C., additional, Young, C., additional, Ruas, M., additional, Grasa, P., additional, Rietdorf, K., additional, Heytens, E., additional, Heindryckx, B., additional, Yoon, S. Y., additional, Fissore, R. A., additional, Deane, C. M., additional, Nikiforaki, D., additional, Tee, S. T., additional, de Sutter, P., additional, Parrington, J., additional, Coward, K., additional, Visser, L., additional, Westerveld, G. H., additional, van Daalen, S. K. M., additional, van der Veen, F., additional, Lombardi, M. P., additional, Repping, S., additional, Cubillos, S., additional, Sanchez, S., additional, Pedraza, J., additional, Charria, G., additional, Aparicio, H., additional, Gongora, A., additional, Caldino, F., additional, Cuneo, S., additional, Ou, J. P., additional, Zhao, W. E., additional, Liu, Y. F., additional, Xu, Y. W., additional, Zhou, C. Q., additional, Al-Asmar Pinar, N., additional, Peinado, V., additional, Gruhn, J., additional, Susiarjo, M., additional, Gil-Salom, M., additional, Martinez-Jabaloyas, J. M., additional, Remohi, J., additional, Rubio, C., additional, Hassold, T., additional, Al-Asmar, N., additional, Rodrigo, L., additional, Hassold, T. J., additional, Bungum, M., additional, Forsell, N., additional, Giwercman, A., additional, Amiri, I., additional, Sheikh, N., additional, Najafi, R., additional, Godarzi, M., additional, Farimani, M., additional, Makukh, H., additional, Tyrkus, M., additional, Zastavna, D., additional, Nakonechnuy, A., additional, Khayat, S. S., additional, Schileiko, L. V., additional, Kurilo, L. F., additional, Garcia-Herrero, S., additional, Garrido, N., additional, Martinez-Conejero, J. A., additional, Romany, L., additional, Meseguer, M., additional, Dorphin, B., additional, Lefevre, M., additional, Gout, C., additional, Oger, P., additional, Yazbeck, C., additional, Rougier, N., additional, De Stefani, S., additional, Scala, V., additional, Benedetti, S., additional, Tagliamonte, M. C., additional, Zavagnini, E., additional, Palini, S., additional, Bulletti, C., additional, Canestrari, F., additional, Subiran, N., additional, Pinto, F. M., additional, Candenas, M. L., additional, Agirregoitia, E., additional, Irazusta, J., additional, Cha, E. M., additional, Lee, J. H., additional, Park, I. H., additional, Lee, K. H., additional, Kim, M. H., additional, Jensen, M. S., additional, Rebordosa, C., additional, Thulstrup, A. M., additional, Toft, G., additional, Sorensen, H. T., additional, Bonde, J. P., additional, Henriksen, T. B., additional, Olsen, J., additional, Bosco, L., additional, Speciale, M., additional, Manno, M., additional, Amireh, N., additional, Roccheri, M. C., additional, Cittadini, E., additional, Wu, P., additional, Lee, Y. M., additional, Chen, H. W., additional, Tzeng, C. R., additional, Llacer, J., additional, Ten, J., additional, Lledo, B., additional, Rodriguez-Arnedo, A., additional, Morales, R., additional, Bernabeu, R., additional, Garcia-Peiro, A., additional, Martinez-Heredia, J., additional, Oliver-Bonet, M., additional, Ribas, J., additional, Abad, C., additional, Amengual, M. J., additional, Navarro, J., additional, Benet, J., additional, Moutou, C., additional, Gardes, N., additional, Nicod, J. C., additional, Becker, N., additional, Bailly, M. P., additional, Galland, I., additional, Pirello, O., additional, Rongieres, C., additional, Wittemer, C., additional, Viville, S., additional, Elmahaishi, W., additional, Smith, B., additional, Doshi, A., additional, Serhal, P., additional, Harper, J. C., additional, Rennemeier, C., additional, Kammerer, U., additional, Dietl, J., additional, Staib, P., additional, Elgmati, K., additional, Nomikos, M., additional, Theodoridou, M., additional, Calver, B., additional, Swann, K., additional, Lai, F. A., additional, Georgiou, I., additional, Lazaros, L., additional, Xita, N., additional, Kaponis, A., additional, Plachouras, N., additional, Hatzi, E., additional, Zikopoulos, K., additional, Ferfouri, F., additional, Clement, P., additional, Molina Gomes, D., additional, Albert, M., additional, Bailly, M., additional, Wainer, R., additional, Selva, J., additional, Vialard, F., additional, Takisawa, T., additional, Usui, K., additional, Kyoya, T., additional, Shibuya, Y., additional, Hattori, H., additional, Sato, Y., additional, Ota, M., additional, Kyono, K., additional, Chiu, P. C., additional, Lam, K. K., additional, Lee, C. L., additional, Chung, M. K., additional, Huang, V. W., additional, O, W. S., additional, Tang, F., additional, Ho, P. C., additional, Yeung, W. S., additional, Kim, C. H., additional, Lee, J. Y., additional, Kim, S. H., additional, Suh, C. S., additional, Shin, Y. K., additional, Kang, Y. J., additional, Jung, J. H., additional, Cha, C. Y., additional, Hwang, E. S., additional, Mukaida, T., additional, Nagaba, M., additional, Takahashi, K., additional, Elkaffash, D., additional, Sedrak, M., additional, Huhtaniemi, I., additional, Abdel-Al, T., additional, Younan, D., additional, Cassuto, N. G., additional, Bouret, D., additional, Hammoud, I., additional, Barak, Y., additional, Seshadri, S., additional, Bates, M., additional, Vince, G., additional, Jones, D. I., additional, Ben Khalifa, M., additional, Montjean, D., additional, Cohen-Bacrie, P., additional, Aubriot, F. X., additional, Cohen, M., additional, Boudjema, E., additional, Magli, M. C., additional, Crippa, A., additional, Baccetti, B., additional, Ferraretti, A. P., additional, Gianaroli, L., additional, Singer, T., additional, Neri, Q. V., additional, Hu, J. C., additional, Maggiulli, R., additional, Kollman, Z., additional, Rauch, E., additional, Schlegel, P. N., additional, Rosenwaks, Z., additional, Palermo, G. D., additional, Zorn, B., additional, Skrbinc, B., additional, Matos, E., additional, Golob, B., additional, Pfeifer, M., additional, Osredkar, J., additional, Sabanegh, E., additional, Sharma, R. K., additional, Thiyagarajan, A., additional, Agarwal, A., additional, Robin, G., additional, Boitrelle, F., additional, Marcelli, F., additional, Marchetti, C., additional, Mitchell, V., additional, Dewailly, D., additional, Rigot, J. M., additional, Rives, N., additional, Perdrix, A., additional, Travers, A., additional, Milazzo, J. P., additional, Mousset-Simeon, N., additional, Mace, B., additional, Jakab, A., additional, Molnar, Z., additional, Benyo, M., additional, Levai, I., additional, Kassai, Z., additional, Ihan, A., additional, Kopitar, A., additional, Kolbezen, M., additional, Vaamonde, D., additional, Da Silva-Grigoletto, M. E., additional, Garcia-Manso, J. M., additional, Vaamonde-Lemos, R., additional, Oehninger, S. C., additional, Walis, G., additional, Monahan, D., additional, Ermolovich, E., additional, Fadlon, E., additional, Abu Elhija, A., additional, Abu Elhija, M., additional, Lunenfeld, E., additional, Huleihel, M., additional, Costantini-Ferrando, M., additional, Hu, J. C. Y., additional, Alvarez, J. G., additional, Velilla, E., additional, Lopez-Teijon, M., additional, Lopez-Fernandez, C., additional, Tempest, H. G., additional, Sun, F., additional, Ko, E., additional, Turek, P., additional, Martin, R. H., additional, Zomeno-Abellan, M. T., additional, Ramirez, A., additional, Gutierrez-Adan, A., additional, Martinez, J. C., additional, Landeras, J., additional, Ballesta, J., additional, Aviles, M., additional, Ganaiem, M., additional, Binder, S., additional, Meinhardt, A., additional, Sousa, L., additional, Grangeia, A., additional, Carvalho, F., additional, Sousa, M., additional, Barros, A., additional, Sifer, C., additional, Sermondade, N., additional, Hafhouf, E., additional, Poncelet, C., additional, Benzacken, B., additional, Levy, R., additional, Wolf, J. P., additional, Crisol, L., additional, Aspichueta, F., additional, Hernandez, M. L., additional, Exposito, A., additional, Matorras, R., additional, Ruiz-Larrea, M. B., additional, Ruiz-Sanz, J. I., additional, Jallad, S., additional, Atig, F., additional, Ben Amor, H., additional, Saad, A. L. I., additional, Kerkeni, A., additional, Ajina, M., additional, Othmane, A. L. I., additional, Koscinski, I., additional, Ladureau, L., additional, Scarselli, F., additional, Casciani, V., additional, Lobascio, M., additional, Minasi, M. G., additional, Rubino, P., additional, Colasante, A., additional, Arizzi, L., additional, Litwicka, K., additional, Iammarrone, E., additional, Ferrero, S., additional, Mencacci, C., additional, Franco, G., additional, Zavaglia, D., additional, Nagy, Z. P., additional, Greco, E., additional, Ohgi, S., additional, Takahashi, M., additional, Kishi, C., additional, Suga, K., additional, Yanaihara, A., additional, Chamley, L. W., additional, Wagner, A., additional, and Shelling, A. N., additional

Published
2010
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13. Posters * Reproductive Endocrinology (i.e. PCOS, Menarche, Menopause etc.)

Author

Fujii, R., primary, Fujita, S., additional, Waseda, T., additional, Oka, Y., additional, Takagi, H., additional, Tomizawa, H., additional, Sasagawa, T., additional, Makinoda, S., additional, Cavagna, M., additional, Braga, D. P. A. F., additional, Figueira, R. C. S., additional, Aoki, T., additional, Maldonado, L. G. L., additional, Iaconelli, A., additional, Borges, E., additional, Prabhakar, s., additional, Dittrich, R., additional, Beckmann, M. W., additional, Hoffmann, I., additional, Mueller, A., additional, Kjotrod, S., additional, Carlsen, S. M., additional, Rasmussen, P. E., additional, Holst-Larsen, T., additional, Mellembakken, J., additional, Thurin-Kjellberg, A., additional, Haapaniemi Kouru, K., additional, Morin Papunen, L., additional, Humaidan, P., additional, Sunde, A., additional, von During, V., additional, Pappalardo, S., additional, Valeri, C., additional, Crescenzi, F., additional, Manna, C., additional, Sallam, H. N., additional, Polec, A., additional, Raki, M., additional, Tanbo, T., additional, Abyholm, T., additional, Fedorcsak, P., additional, Tabanelli, C., additional, Ferraretti, A. P., additional, Feliciani, E., additional, Magli, M. C., additional, Fasolino, C., additional, Gianaroli, L., additional, Wang, T., additional, Feng, C., additional, Song, Y., additional, Dong, M. Y., additional, Sheng, J. Z., additional, Huang, H. F., additional, Sayyah Melli, M., additional, Kazemi-shishvan, M., additional, Snajderova, M., additional, Zemkova, D., additional, Pechova, M., additional, Teslik, L., additional, Lanska, V., additional, Ketel, I., additional, Serne, E., additional, Stehouwer, C., additional, Korsen, T., additional, Hompes, P., additional, Smulders, Y., additional, Voorstemans, L., additional, Homburg, R., additional, Lambalk, C., additional, Bellver, J., additional, Martinez-Conejero, J. A., additional, Pellicer, A., additional, Labarta, E., additional, Alama, P., additional, Melo, M. A. B., additional, Horcajadas, J. A., additional, Agirregoitia, N., additional, Peralta, L., additional, Mendoza, R., additional, Exposito, A., additional, Matorras, R., additional, Agirregoitia, E., additional, Ajina, M., additional, Chaouache, N., additional, Gaddas, M., additional, Souissi, A., additional, Tabka, Z., additional, Saad, A., additional, Zaouali-Ajina, M., additional, Zbidi, A., additional, Eguchi, N., additional, Jinno, M., additional, Watanabe, A., additional, Hirohama, J., additional, Hatakeyama, N., additional, Choi, Y. M., additional, Kim, J. J., additional, Kim, D. H., additional, Yoon, S. H., additional, Ku, S. Y., additional, Kim, S. H., additional, Kim, J. G., additional, Lee, K. S., additional, Moon, S. Y., additional, Xiong, Y., additional, Liang, X., additional, Li, Y., additional, Yang, X., additional, Wei, L., additional, Fujii, R., additional, Utsunomiya, T., additional, Chu, S., additional, Li, P., additional, Akarsu, S., additional, Dirican, E. K., additional, Akin, K. O., additional, Kormaz, C., additional, Goktolga, U., additional, Ceyhan, S. T., additional, Kara, C., additional, Nadamoto, K., additional, Tarui, S., additional, Ida, M., additional, Sugihara, K., additional, Haruki, A., additional, Hukuda, A., additional, Morimoto, Y., additional, Albu, A., additional, Albu, D., additional, Sandu, L., additional, Kong, G., additional, Cheung, L., additional, Lok, I., additional, Pinto, A., additional, Teixeira, L., additional, Figueiredo, H., additional, Pires, I., additional, Silva Carvalho, J. L., additional, Pereira, M. L., additional, Faut, M., additional, de Zuniga, I., additional, Colaci, D., additional, Barrios, E., additional, Oubina, A., additional, Terrado Gil, G., additional, Motta, A., additional, Horton, M., additional, Sobral, F., additional, Gomez Pena, M., additional, Gleicher, N., additional, Barad, D. H., additional, Li, Y. P., additional, Zhao, H. C., additional, Spaczynski, R. Z., additional, Guzik, P., additional, Banaszewska, B., additional, Krauze, T., additional, Wykretowicz, A., additional, Wysocki, H., additional, Pawelczyk, L., additional, Sarikaya, E., additional, Gulerman, C., additional, Cicek, N., additional, Mollamahmutoglu, L., additional, Venetis, C. A., additional, Kolibianakis, E. M., additional, Toulis, K., additional, Goulis, D., additional, Loutradi, K., additional, Chatzimeletiou, K., additional, Papadimas, I., additional, Bontis, I., additional, Tarlatzis, B. C., additional, Schultze-Mosgau, A., additional, Griesinger, G., additional, Schoepper, B., additional, Cordes, T., additional, Diedrich, K., additional, Al-Hasani, S., additional, Gomez, R., additional, Jovanovic, V., additional, Sauer, C. M., additional, Shawber, C. J., additional, Sauer, M. V., additional, Kitajewski, J., additional, Zimmermann, R. C., additional, Bungum, L., additional, Jacobsson, A. K., additional, Rosen, F., additional, Becker, C., additional, Andersen, C. Y., additional, Guner, N., additional, Giwercman, A., additional, Kiapekou, E., additional, Zapanti, E., additional, Boukelatou, D., additional, Mavreli, T., additional, Bletsa, R., additional, Stefanidis, K., additional, Drakakis, P., additional, Mastorakos, G., additional, Loutradis, D., additional, Malhotra, N., additional, Sharma, V., additional, Kumar, S., additional, Roy, K. K., additional, Sharma, J. B., additional, Ferraretti, A., additional, Crippa, A., additional, Stanghellini, I., additional, Robles, F., additional, Serdynska-Szuster, M., additional, Kristensen, S. L., additional, Ernst, E., additional, Toft, G., additional, Olsen, S. F., additional, Bonde, J. P., additional, Vested, A., additional, Ramlau-Hansen, C. H., additional, Wang, F. F., additional, Qu, F., additional, Ding, G. L., additional, Gallot, V., additional, Genro, V., additional, Roux, I., additional, Scheffer, J. B., additional, Frydman, R., additional, Fanchin, R., additional, Kanta Goswami, S., additional, Banerjee, S., additional, Chakravarty, B. N., additional, Kabir, S. N., additional, Seeber, B. E., additional, Morandell, E., additional, Kurzthaler, D., additional, Wildt, L., additional, Dieplinger, H., additional, Tutuncu, L., additional, Bodur, S., additional, Dundar, O., additional, Ron - El, R., additional, Seger, R., additional, Komarovsky, D., additional, Kasterstein, E., additional, Komsky, A., additional, Maslansky, B., additional, Strassburger, D., additional, Ben-Ami, I., additional, Zhao, X. M., additional, Ni, R. M., additional, Lin, L., additional, Dong, M., additional, Tu, C. H., additional, He, Z. H., additional, Yang, D. Z., additional, Karamalegos, C., additional, Polidoropoulos, N., additional, Papanikopoulos, C., additional, Stefanis, P., additional, Argyrou, M., additional, Doriza, S., additional, Sisi, V., additional, Moschopoulou, M., additional, Karagianni, T., additional, Mentorou, C., additional, Economou, K., additional, Davies, S., additional, Mastrominas, M., additional, Gougeon, A., additional, De Los Santos, M. J., additional, Garcia-Laez, V., additional, Esteban, F., additional, Crespo, J., additional, Li, H. W. R., additional, Anderson, R. A., additional, Yeung, W. S. B., additional, Ho, P. C., additional, Ng, E. H. Y., additional, Yang, H. I., additional, Lee, K. E., additional, Seo, S. K., additional, Kim, H. Y., additional, Cho, S. H., additional, Choi, Y. S., additional, Lee, B. S., additional, Park, K. H., additional, Cho, D. J., additional, Hart, R., additional, Doherty, D., additional, Mori, T., additional, Hickey, M., additional, Sloboda, D., additional, Norman, R., additional, Huang, R. C., additional, Beilin, L., additional, Freiesleben, N., additional, Lossl, K., additional, Johannsen, T. H., additional, Loft, A., additional, Bangsboll, S., additional, Hougaard, D., additional, Friis-Hansen, L., additional, Christiansen, M., additional, Nyboe Andersen, A., additional, Thum, M. Y., additional, Abdalla, H., additional, Martinez-Salazar, J., additional, De la Fuente, G., additional, Kohls, G., additional, Garcia Velasco, J. A., additional, Yasmin, E., additional, Kukreja, S., additional, Barth, J., additional, Balen, A. H., additional, Esra, T., additional, Var, T., additional, Citil, A., additional, Dogan, M., additional, Messini, C. I., additional, Dafopoulos, K., additional, Chalvatzas, N., additional, Georgoulias, P., additional, Anifandis, G., additional, Messinis, I. E., additional, Celik, O., additional, Hascalik, S., additional, Celik, N., additional, Sahin, I., additional, Aydin, S., additional, Hanna, C. W., additional, Bretherick, K. L., additional, Liu, C. C., additional, Stephenson, M. D., additional, Robinson, W. P., additional, Louwers, Y. V., additional, Goodarzi, M. O., additional, Taylor, K. D., additional, Jones, M. R., additional, Cui, J., additional, Kwon, S., additional, Chen, Y. D. I., additional, Guo, X., additional, Stolk, L., additional, Uitterlinden, A. G., additional, Laven, J. S. E., additional, Azziz, R., additional, Navaratnarajah, R., additional, Grun, B., additional, Sinclair, J., additional, Dafou, D., additional, Gayther, S., additional, Timms, J. F., additional, Hardiman, P. J., additional, Ye, Y., additional, Wu, R., additional, Ou, J., additional, Kim, S. D., additional, Jee, B. C., additional, Lee, J. Y., additional, Suh, C. S., additional, Jung, J. H., additional, Opmeer, B. C., additional, Broeze, K. A., additional, Coppus, S. F., additional, Collins, J. A., additional, Den Hartog, J. E., additional, Land, J. A., additional, Van der Linden, P. J., additional, Marianowski, P., additional, Ng, E., additional, Van der Steeg, J. W., additional, Steures, P., additional, Strandell, A., additional, Mol, B. W., additional, Tarlatzi, T. B., additional, Kyrou, D., additional, Mertzanidou, A., additional, Fatemi, H. 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M., additional, Lucco, F., additional, Pozzobon, C., additional, Lara, E., additional, Galliano, D., additional, Ballesteros, A., additional, Ghoshdastidar, B., additional, Maity, S. P., additional, Ghoshdastidar, S., additional, Luna, M., additional, Vela, G., additional, Sandler, B., additional, Barritt, J., additional, Flisser, E. D., additional, Copperman, A. 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J., additional, Dreesen, L., additional, Vandersteen, M., additional, Neumann, C., additional, Zollner, U., additional, Kato, K., additional, Segawa, T., additional, Kawachiya, S., additional, Okuno, T., additional, Kobayashi, T., additional, Takehara, Y., additional, Kato, O., additional, Jayaprakasan, K., additional, Nardo, L., additional, Hopkisson, J., additional, Campbell, B., additional, and Raine-Fenning, N., additional

Published
2010
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14. Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)

Author

Axmon, A., primary, Thulstrup, A.-M., additional, Rignell-Hydbom, A., additional, Pedersen, H.S., additional, Zvyezday, V., additional, Ludwicki, J.K., additional, Jönsson, B.A.G., additional, Toft, G., additional, Bonde, J.-P., additional, and Hagmar, L., additional

Published
2005
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16. Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study.

Author

Lyngsø, J, Ramlau-Hansen, C H, Høyer, B B, Støvring, H, Bonde, J P, Jönsson, B A G, Lindh, C H, Pedersen, H S, Ludwicki, J K, Zviezdai, V, and Toft, G

Abstract

Study Question: Does perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) exposure disrupt the menstrual cyclicity?Summary Answer: The female reproductive system may be sensitive to PFOA exposure, with longer menstrual cycle length at higher exposure.What Is Known Already: PFOS and PFOA are persistent man-made chemicals. Experimental animal studies suggest they are reproductive toxicants but epidemiological findings are inconsistent.Study Design, Size, Duration: A cross-sectional study including 1623 pregnant women from the INUENDO cohort enrolled during antenatal care visits between June 2002 and May 2004 in Greenland, Poland and Ukraine.Participants/materials, Setting, Methods: Information on menstrual cycle characteristics was obtained by questionnaires together with a blood sample from each pregnant woman. Serum concentrations of PFOS and PFOA were measured by liquid chromatography tandem mass spectrometry. Multiple imputations were performed to account for missing data. The association between PFOS/PFOA and menstrual cycle length (short cycle: ≤24 days, long cycle: ≥32 days) and irregularities (≥7 days in difference between cycles) was analyzed using logistic regression with tertiles of exposure. Estimates are given as adjusted odds ratios (ORs) with 95% confidence intervals (CIs).Main Results and the Role Of Chance: Higher exposure levels of PFOA were associated with longer menstrual cycles in pooled estimates of all three countries. Compared with women in the lowest exposure tertile, the adjusted OR of long cycles was 1.8 (95% CI: 1.0; 3.3) among women in the highest tertile of PFOA exposure. No significant associations were observed between PFOS exposure and menstrual cycle characteristics. However, we observed a tendency toward more irregular cycles with higher exposure to PFOS [OR 1.7 (95% CI: 0.8; 3.5)]. The overall response rate was 45.3% with considerable variation between countries (91.3% in Greenland, 69.1% in Poland and 26.3% in Ukraine).Limitations, Reasons For Caution: Possible limitations in our study include varying participation rates across countries; a selected study group overrepresenting the most fertile part of the population; retrospective information on menstrual cycle characteristics; the determination of cut-points for all three outcome variables; and lacking information on some determinants of menstrual cycle characteristics, such as stress, physical activity, chronic diseases and gynecological disorders, thus confounding cannot be excluded.Wider Implications Of the Findings: The generalizability of the study results is restricted to fertile women who manage to conceive and women who do not use oral contraceptives when getting pregnant or within 2 months before getting pregnant. To our knowledge only one previous epidemiological study has addressed the possible association between perfluorinated chemical exposure and menstrual disturbances. Though pointing toward different disturbances in cyclicity, both studies suggest that exposure to PFOA may affect the female reproductive function. This study contributes to the limited knowledge on effects of exposure to PFOA and PFOS on female reproductive function and suggests that the female reproductive system may be affected by environmental exposure to PFOA.Study Funding/competing Interest(s): Supported by a scholarship from Aarhus University Research Foundation. The collection of questionnaire data and blood samples was part of the INUENDO project supported by The European Commission (Contract no. QLK4-CT-2001-00 202), www.inuendo.dk. The Ukrainian part of the study was possible by a grant from INTAS (project 012 2205). Determination of PFOA and PFOS in serum was part of the CLEAR study (www.inuendo.dk/clear) supported by the European Commission's 7th Framework Program (FP7-ENV-2008-1-226217). No conflict of interest declared. [ABSTRACT FROM AUTHOR]

Published
2014
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18. Computer-assisted semen analysis parameters as predictors for fertility of men from the general population. The Danish First Pregnancy Planner Study Team.

Author

Larsen, Lene, Scheike, Thomas, Jensen, Tina Kold, Bonde, Jens Peter, Ernst, Erik, Hjollund, Niels Henrik, Zhou, Yue, Skakkebök, Niels Erik, Giwercman, Aleksander, Larsen, L, Scheike, T, Jensen, T K, Bonde, J P, Ernst, E, Hjollund, N H, Zhou, Y, Skakkebaek, N E, and Giwercman, A

Subjects
BIRTH rate, FERTILITY, MULTIVARIATE analysis, PROGNOSIS, QUESTIONNAIRES, REFERENCE values, REGRESSION analysis, SEMEN, SPERM motility, PREDICTIVE tests, SPERM count, COMPUTER-aided diagnosis
Abstract

The predictive value of sperm motility parameters obtained by computer-assisted semen analysis (CASA) was evaluated for the fertility of men from general population. In a prospective study with couples stopping use of contraception in order to try to conceive, CASA was performed on semen samples from 358 men. A recently developed CASA system, Copenhagen Rigshospitalet Image house sperm Motility Analysis System (CRISMAS) was used for assessment of motility parameters. This system has an editing function which allows correction of tracks made by the computer. Probably due to this function, the concentration assessment made by CRISMAS was very close to that made by the technician (median difference <5%) in all concentration ranges. Correlation between CASA parameters and fertility of normal couples (measured as probability of achieving pregnancy) was examined by the Cox regression model. In univariate models ln(sperm concentration) [beta = 0.331, risk ratio (RR) = 1.392, P = 0.0001], ln(total sperm count) (beta = 0.252, RR = 1.286, P = 0.0007) and percentage motile spermatozoa (beta = 0.014, RR = 1.014, P = 0.0004) were most significant predictors for fertility. In a multivariate analysis ln(sperm concentration) (beta = 0.268, RR = 1.307, P = 0.0016) and percentage motile spermatozoa (beta = 0.010, RR = 1.010, P = 0.011) but even more significantly the combined parameter, ln(concentration of motile spermatozoa) (beta = 0.329, RR = 1.389, P = 0.0001), were the only parameters of predictive value for fertility of men in the general population. In conclusion, these parameters obtained by CASA measurements can be used for prediction of fertility potential in normal men. This appears to be the first study showing the value of CASA in prediction of fertility in the general male population. [ABSTRACT FROM AUTHOR]

Published
2000
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19. Is glycosylated haemoglobin a marker of fertility? A follow-up study of first-pregnancy planners.

Author

Hjollund, N H, Jensen, T K, Bonde, J P, Henriksen, T B, Andersson, A M, and Skakkebaek, N E

Abstract

We performed a follow-up study of time to pregnancy in a population of first-time pregnancy planners without previous reproductive experience. The objective of this paper is to report and discuss a finding of a strong relationship between glycosylated haemoglobin (HbA1C) and fertility. A total of 165 Danish couples without previous reproductive experience was followed from termination of birth control until pregnancy for a maximum of six menstrual cycles. HbA1C and reproductive hormones were measured at entry. Questionnaire data were collected at entry and once in each cycle during follow-up. The odds ratio (OR) for pregnancy per cycle decreased with increasing concentration of HbA1C (OR per percent HbA1C 0.4, 95% CI 0.2-0.9 for all six cycles and 0.2, 95% CI 0.1-0.5 in the first three cycles). A high concentration of HbA1C was associated with a high concentration of testosterone and a low concentration of inhibin A. No association was found between HbA1C and psychosocial distress. The reduced fertility among women with high HbA1C may be due to an association with subclinical polycystic ovaries as indicated by the hormonal profile. [ABSTRACT FROM AUTHOR]

Published
1999
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