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Integral parameters of bacterial lipopolysaccharide concentration and antiendotoxin immunity activity were determined in the blood serum of subjects with two extreme variants of eating disorders: obesity and anorexia nervosa (in its clinical model, long-term starvation). The results of the study showed that obese patients had initially higher endotoxin concentrations (2.41 ± 0.11 vs 1.13 ± 0.05 EU/mL in the control), which significantly decreased as a result taking a course of orlistat or after starvation (for no longer than 20 days) (to 1.34 ± 0.04 and 1.01 ± 0.09 EU/mL, respectively). The decrease in the endotoxin serum level was associated with an increase in the concentration of high-density lipoproteins (HDLs) and a decrease in the concentration of low-density lipoproteins (LDLs). This allowed us to assume that the complex of the latter with the endotoxin is the LDL fraction that may function as a depot of the hydrophobic form of the lipopolysaccharide molecule in the bloodstream. Long-term starvation (starting from day 20) led to the appearance of symptoms characteristic of septic states, which was preceded by a twofold increase in the concentration of the endotoxin and antibodies against the enterobacterial common antigen and subsequent increase in the level of anti-glycolipid antibodies (from 133.2 ± 2.6 to 355.6 ± 15.0 optical density arbitrary units) starting from day 25–27 of starvation, which is characteristic for the initial phase of the systemic inflammatory response syndrome.

The role of the kidneys in endotoxin aggression (EA) and the involvement of EA in disturbance of hemostasis were shown in 33 children with congenital urological pathology. With a progressive decrease in the accumulative-excretory function of the kidneys, compensated chronic EA became subcompensated or noncompensated with a pronounced clinical manifestation: fever, exacerbation of chronic pyelonephritis, an expanded form of the disseminated intravascular coagulation (DIC) III syndrome, and macrohematuria. Preoperative correction of antiendotoxin immunity and hemostasis and improvement of urine passage prevented bleeding and other postoperative complications.

The authors examined students of specialized secondary education institutions of Syktyvkar during a three-year-long period. Some morphofunctional indices are worse in them than in similar cohorts in Central Russia. The unfavorable environmental situation impaired tolerance to hypoxemia, cardiac rhythm regulation, central hemodynamics, and balance of autonomic processes and affected dynamics of the physiological status of the body during social adaptation to learning.