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Your search keyword '"Gaudiano, M."' showing total 2 results
Start Over Author "Gaudiano, M." Journal human pathology
2 results on '"Gaudiano, M."'

1. Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma

Author

Giovannino Ciccone, Francesca Maletta, Anna Sapino, Pier Luigi Filosso, Nicola Veronese, Francesco Guerrera, Alberto Oliaro, Fabrizio Tabbò, Marcello Gaudiano, Claudio Luchini, Enrico Ruffini, Giorgio Inghirami, Luisa Delsedime, Licia Montagna, Filomena Di Giacomo, Alessia Nottegar, Aldo Scarpa, Marco Chilosi, Enrica Migliore, Tabbò, F., Nottegar, A., Guerrera, F., Migliore, E., Luchini, C., Maletta, F., Veronese, N., Montagna, L., Gaudiano, M., Di Giacomo, F., Filosso, P.L., Delsedime, L., Ciccone, G., Scarpa, A., Sapino, A., Oliaro, A., Ruffini, E., Inghirami, G., and Chilosi, M.

Subjects
Lung adenocarcinoma, Morphology, Adult, Male, 0301 basic medicine, Oncology, Biomarkers, Genetic mutations, Immunohistochemistry, Survival analysis, Pathology, medicine.medical_specialty, Candidate gene, Cell of origin, six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), Adenocarcinoma of Lung, Kaplan-Meier Estimate, genetic mutations, Gene mutation, Biology, medicine.disease_cause, adenocarcinoma (ADC), survival analysis, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, morphology, Biomarkers, Tumor, medicine, Humans, CDX2, Aged, biomarkers, immunohistochemistry, lung adenocarcinoma, Middle Aged, respiratory system, Prognosis, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, KRAS
Abstract

Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), defining the putative neoplastic “cell of origin,” allows to identify prognostic subgroups among lung ADC. We screened a large cohort of ADC specimens (2003–2013) from Torino Institutional Repository identifying: (i) marker positivity by immunohistochemistry, (ii) main morphological appearance by light microscopy, (iii) presence of “hotspot” mutations of candidate genes by Sequenom technology. To evaluate possible predictors of survival and time to recurrence, uni- and multivariable-adjusted comparisons were performed. We identified 4 different subgroups: “alveolar,” “bronchiolar,” “mixed” and “null type." Alveolar-differentiated ADC were more common in young (P =.065), female (P =.083) patients, frequently harboring EGFR-mutated (P =.003) tumors with acinar pattern (P

Published
2018

2. Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma.

Author

Tabbò F, Nottegar A, Guerrera F, Migliore E, Luchini C, Maletta F, Veronese N, Montagna L, Gaudiano M, Di Giacomo F, Filosso PL, Delsedime L, Ciccone G, Scarpa A, Sapino A, Oliaro A, Ruffini E, Inghirami G, and Chilosi M

Subjects
Adenocarcinoma of Lung mortality, Adult, Aged, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Adenocarcinoma of Lung pathology, Biomarkers, Tumor analysis
Abstract

Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), defining the putative neoplastic "cell of origin," allows to identify prognostic subgroups among lung ADC. We screened a large cohort of ADC specimens (2003-2013) from Torino Institutional Repository identifying: (i) marker positivity by immunohistochemistry, (ii) main morphological appearance by light microscopy, (iii) presence of "hotspot" mutations of candidate genes by Sequenom technology. To evaluate possible predictors of survival and time to recurrence, uni- and multivariable-adjusted comparisons were performed. We identified 4 different subgroups: "alveolar," "bronchiolar," "mixed" and "null type." Alveolar-differentiated ADC were more common in young (P=.065), female (P=.083) patients, frequently harboring EGFR-mutated (P=.003) tumors with acinar pattern (P<.001). Bronchiolar-differentiated ADC were more associated with mucinous and solid pattern (P<.001), higher degree of vascular invasion (P=.01) and KRAS gene mutations (P=.07). Bronchiolar, mixed, and null types were independent negative predictors for overall survival, and the latter two had a shorter time to recurrence. This "Cell of Origin" classifier is more predictable than morphology and genetics and is an independent predictor of survival on a multivariate analysis., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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