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Your search keyword '"T. E. Starzl"' showing total 15 results
Start Over Author "T. E. Starzl" Journal human immunology
15 results on '"T. E. Starzl"'

2. Serial in vitro studies in bone marrow augmented liver transplant recipients

Author

S. Lombardozzi, O. Pappo, J. Demetris, John J. Fung, M. Pavlick, T. E. Starzl, Paulo Fontes, A.S. Rao, Forrest Dodson, A. Zeevi, and Banas Richard A

Subjects
Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, Bone marrow, business, In vitro
Published
1994
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3. Monitoring immune reactivity in bone marrow augmented kidney recipients

Author

M. Pavlick, John J. Fung, J. Demetris, Velma P. Scantlebury, A. Zeevi, Paulo Fontes, Mark L. Jordan, S. Lombardozzi, O. Pappo, A.S. Rao, Banas Richard A, T. E. Starzl, and Ron Shapiro

Subjects
Kidney, medicine.anatomical_structure, business.industry, Immunology, medicine, Immunology and Allergy, Reactivity (chemistry), General Medicine, Bone marrow, Immune monitoring, business
Published
1994
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5. Isolation and in vitro function of baboon pancreatic islets and their capacity to reverse experimental diabetes in nude mice

Author

A.S. Rao, Camillo Ricordi, Patricia B. Carroll, T. E. Starzl, Paulo Fontes, C. Rastellini, H. R L Rilo, and R. Behboo

Subjects
Pancreatic islets, Immunology, General Medicine, Biology, Isolation (microbiology), In vitro, Andrology, medicine.anatomical_structure, biology.animal, medicine, Immunology and Allergy, Function (biology), Baboon, Experimental diabetes
Published
1994
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6. Projection from humoral rejection by a xenografted liver

Author

Luis A. Valdivia, T. E. Starzl, H. Sun, A.S. Rao, S. Celli, A.J. Demetris, F. Pan, John J. Fung, and M. Tsugita

Subjects
Physics, business.industry, Immunology, Immunology and Allergy, Computer vision, General Medicine, Artificial intelligence, Projection (set theory), business
Published
1994
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7. HLA donor-recipient compatibility and cytomegalovirus (CMV) hepatitis after liver transplantation

Author

J. Demetris, T. E. Starzl, S. Kusne, P. Linden, David J. Kramer, Rafael Mañez, Maureen Martin, R. J. Duquesnoy, and Linda T. White

Subjects
Cmv hepatitis, business.industry, medicine.medical_treatment, Immunology, Congenital cytomegalovirus infection, Immunology and Allergy, Medicine, General Medicine, Human leukocyte antigen, Liver transplantation, business, medicine.disease, Virology
Published
1992
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9. Flow cytometric analysis of activation actigens on human T-cell subsets: Influence of the immunosuppressive macrolide FK-506 and nucleotide synthetase inhibitors

Author

T. E. Starzl, Angus W. Thomson, S. Todo, A. Zeevi, and Jacky Woo

Subjects
chemistry.chemical_classification, medicine.anatomical_structure, Biochemistry, chemistry, Flow (mathematics), T cell, Immunology, medicine, Immunology and Allergy, Nucleotide, General Medicine, Biology, Molecular biology
Published
1991
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12. An adverse effect of a positive crossmatch in orthotopic liver allograft

Author

T. E. Starzl, Y. Yoshida, K. Noguchi, M. Kobayashi, A. Konno, R. J. Duquesnoy, T. Takenaka, M. Vanek, K. Tanaka, S. Hayashi, Yuichi Iwaki, and Atsuhito Yagihashi

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Immunology, medicine, Immunology and Allergy, General Medicine, Adverse effect, business, Gastroenterology, Positive crossmatch
Published
1991
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13. Effects of immunosuppressive macrolides and nucleotide synthetase inhibitors on proliferation of lymphoid cells induced via distinct signal transduction pathways

Author

S. Todo, T. E. Starzl, G.Z. Rao, R. J. Duquesnoy, M. Woan, Raman Venkataramanan, Angus W. Thomson, and Adriana Zeevi

Subjects
chemistry.chemical_classification, Biochemistry, Chemistry, Immunology, Immunology and Allergy, Nucleotide, General Medicine, Signal transduction, Cell biology
Published
1991
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14. Sensitivity of activated human lymphocytes to cyclosporine and its metabolites

Author

Rene Duquesnoy, Noriko Murase, C.P. Wang, Gilbert J. Burckart, T. E. Starzl, D. H. Van Thiel, Leonard Makowka, Zeevi A, and Raman Venkataramanan

Subjects
Biopsy, T-Lymphocytes, Metabolite, medicine.medical_treatment, Lymphocyte, Immunology, Dose-Response Relationship, Immunologic, Cyclosporins, Lymphocyte proliferation, In Vitro Techniques, Liver transplantation, Pharmacology, Lymphocyte Activation, chemistry.chemical_compound, medicine, Bile, Humans, Immunology and Allergy, Chromatography, High Pressure Liquid, Immunosuppression Therapy, biology, Immunosuppression, General Medicine, T lymphocyte, Clone Cells, Liver Transplantation, medicine.anatomical_structure, Liver, chemistry, Cell culture, Concanavalin A, biology.protein, Heart Transplantation, Lymphocyte Culture Test, Mixed
Abstract

Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and metabolites fractionated from human bile. Significant differences were observed in Cyclosporine A sensitivity between various cell cultures ranging as high as 100-fold. The liver is the primary site of Cyclosporine A metabolism, which yields a number of hydroxylated and N-dimethylated derivatives that are eventually secreted into the bile. Bile was collected from adult liver transplant patients on Cyclosporine A therapy and following extraction with diethyl ether, separated by high pressure liquid chromatography. Thirteen fractions were tested for their effect on lymphocyte proliferation in concanavalin A activation, mixed lymphocyte cultures and primed lymphocyte test assays. The strongest immunosuppressive effect was found with fraction 8, which contained metabolite M17, which has a single hydroxylation in position 1. Only three other fractions 9, 10, and 13, which contained metabolites M1, M18, and M21, respectively, exhibited immunosuppressive activity, albeit much lower than that of Cyclosporine A. Differences in Cyclosporine A sensitivity among alloreactive T cells followed similar patterns with Cyclosporine A metabolites. Thus, the assessment of the Cyclosporine A effect must consider differences in drug sensitivity of lymphocytes involved in transplant immunity and the generation of metabolites with immunosuppressive activity.

Published
1988
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