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Start Over Descriptor "LU domain" Journal human genomics
2 results on '"LU domain"'

1. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.

Author

Loughner, Chelsea L., Bruford, Elspeth A., McAndrews, Monica S., Delp, Emili E., Swamynathan, Sudha, and Swamynathan, Shivalingappa K.

Abstract

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members. [ABSTRACT FROM AUTHOR]

Published
2016
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2. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Author

Monica S. McAndrews, Chelsea L. Loughner, Emili E. Delp, Shivalingappa K. Swamynathan, Sudha Swamynathan, and Elspeth A. Bruford

Subjects
0301 basic medicine, Neutrophils, Protein domain, Biology, Ly6/uPAR family, Proteomics, Genome, Three-finger domain, Chromosomes, Receptors, Urokinase Plasminogen Activator, 03 medical and health sciences, Mice, LU domain, Protein structure, Protein Domains, Drug Discovery, Genetics, Animals, Antigens, Ly, Humans, Lymphocytes, Molecular Biology, Gene, Genomic organization, Genome, Human, Gene Family Update, Subcellular localization, Urokinase receptor, 030104 developmental biology, Multigene Family, Molecular Medicine, uPAR, Signal Transduction
Abstract

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.

Published
2016

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