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This review article describes the current status of data archiving and computational infrastructure in the field of genomic medicine, focusing primarily on the situation in Japan. I begin by introducing the status of supercomputer operations in Japan, where a high-performance computing infrastructure (HPCI) is operated to meet the diverse computational needs of science in general. Since this HPCI consists of supercomputers of various architectures located across the nation connected via a high-speed network, including supercomputers specialized in genome science, the status of its response to the explosive increase in genomic data, including the International Nucleotide Sequence Database Collaboration (INSDC) data archive, is explored. Separately, since it is clear that the use of commercial cloud computing environments needs to be promoted, both in light of the rapid increase in computing demands and to support international data sharing and international data analysis projects, I explain how the Japanese government has established a series of guidelines for the use of cloud computing based on its cybersecurity strategy and has begun to build a government cloud for government agencies. I will also carefully consider several other issues of user concern. Finally, I will show how Japan's major cloud computing infrastructure is currently evolving toward a multicloud and hybrid cloud configuration. Genomics: Cloud environments for data analysis in Japan An overview of the computational infrastructure available for genomic research in Japan highlights the importance of establishing hybrid cloud computing platforms. The enormous growth of genomic data necessitates a corresponding increase in computational infrastructure for analyses. A review by Osamu Ogasawara of Japan's National Institute of Genetics, Shizuoka, Japan, highlights the strengths and challenges in the country's computational infrastructure. Several powerful supercomputers are linked to universities by a high-speed network for transferring large data sets. Commercial cloud services also provide on-demand availability, easy international collaboration, and reproducible workflows. However, the cloud market is dominated by three vendors, and there are concerns about privacy and data security. Ogasawara advocates a hybrid cloud approach allowing for on-premise analyses and movement between vendors, and notes that the government is developing a multi-cloud environment for domestic institutes. [ABSTRACT FROM AUTHOR]