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Start Over Author "Jingzhou Chen" Journal human genetics
3 results on '"Jingzhou Chen"'

1. A functional variant of the collagen type III alpha1 gene modify risk of sporadic intracranial aneurysms

Author

Yuhua Jiang, Yufang Zhu, Kai Sun, Hui Yu, Youxiang Li, Liming Luan, Weihua Song, Qi Pang, Jingzhou Chen, Peng Jiang, Kejia Lou, and Rutai Hui

Subjects
Male, China, medicine.medical_specialty, Genotype, Population, Biology, Polymorphism, Single Nucleotide, Gastroenterology, Gene Frequency, Polymorphism (computer science), Internal medicine, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, Allele, education, Allele frequency, Stroke, Alleles, Genetic Association Studies, Genetics (clinical), Intracerebral hemorrhage, education.field_of_study, Genetic Variation, Intracranial Aneurysm, Odds ratio, Middle Aged, medicine.disease, Collagen Type III, Female
Abstract

Abnormalities in type III collagen in the arterial walls cause certain familial intracranial aneurysms (IAs); however, it remains unknown whether COL3A1 variants contribute to the risk of sporadic IAs. To study whether COL3A1 variants are associated with sporadic IAs, the association of COL3A1 variants with sporadic IAs was tested in 298 cases and 488 controls, replicated in an independent population of 192 cases and 1,690 controls, and further verified in 633 patients with intra-cerebral hemorrhage, 1,074 hypertensives, and 1,883 controls. We found that allele A of SNP rs1800255 conferred a 1.71-fold increased risk for IAs (adjusted odds ratio: OR = 1.71, 95% confidence interval: CI 1.19-2.45, P = 0.004) and results in an amino acid change of Ala698Thr, which led to a lower thermal stability of the peptide. These results were confirmed in the independent study. The associations were independent of the presence of hemorrhagic stroke and hypertension. These results support the view that the functional variant of COL3A1 is genetic risk factors for IAs in the Chinese population.

Published
2012

2. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case-control study

Author

Jingzhou Chen, Ying Xin, Xiaojian Wang, Xiaodong Song, Kai Sun, Zhe Liu, Yongyi Bai, Yibo Wang, Rutai Hui, Junhao Liu, Weili Zhang, and Hu Wang

Subjects
Oncology, Male, medicine.medical_specialty, Candidate gene, Genotype, 5-Lipoxygenase-Activating Proteins, DNA Mutational Analysis, Disease, Gene interaction, Asian People, Gene Frequency, Risk Factors, Internal medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, Allele, Stroke, Receptor, Notch3, Genetics (clinical), Alleles, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Multifactor dimensionality reduction, biology, Models, Genetic, Receptors, Notch, Case-control study, Membrane Proteins, Middle Aged, medicine.disease, Logistic Models, Methylenetetrahydrofolate reductase, Case-Control Studies, biology.protein, Female, Intracranial Thrombosis, Carrier Proteins
Abstract

Stroke is a common complex trait and does not follow Mendelian pattern of inheritance. Gene-gene or gene-environment interactions may be responsible for the complex trait. How the interactions contribute to stroke is still under research. This study aimed to explore the association between gene-gene interactions and stroke in Chinese in a large case-control study. Nearly 4,000 participants were recruited from seven clinical centers. Eight variants in five candidate genes were examined for stroke risk. Gene-gene interactions were explored by using Generalized Multifactor Dimensionality Reduction (GMDR). A significant gene-gene interaction was found by GMDR. The best model including MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T scored 10 for Cross-Validation Consistency and 9 for Sign Test (P = 0.0107). The individuals with combination of MTHFR 677TT, ALOX5AP 2354AA and NOTCH3 381TT/TC had a significantly higher risk of thrombotic stroke (OR 3.165, 95% CI 1.461-6.858, P = 0.003). Our results show that combination of these alleles conferred higher risk for stroke than single risk allele. The gene-gene interaction may serve as a novel area for stroke research. The three-locus combination may change the susceptibility of particular subjects to the disease.

Published
2009

3. Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case–control study.

Author

Junhao Liu, Kai Sun, Yongyi Bai, Weili Zhang, Xiaojian Wang, Yibo Wang, Hu Wang, Jingzhou Chen, Xiaodong Song, Ying Xin, Zhe Liu, and Rutai Hui

Subjects
CEREBROVASCULAR disease, HUMAN genetics, GENOTYPE-environment interaction, QUANTITATIVE research, MEDICAL sciences
Abstract

Stroke is a common complex trait and does not follow Mendelian pattern of inheritance. Gene–gene or gene–environment interactions may be responsible for the complex trait. How the interactions contribute to stroke is still under research. This study aimed to explore the association between gene–gene interactions and stroke in Chinese in a large case–control study. Nearly 4,000 participants were recruited from seven clinical centers. Eight variants in five candidate genes were examined for stroke risk. Gene–gene interactions were explored by using Generalized Multifactor Dimensionality Reduction (GMDR). A significant gene–gene interaction was found by GMDR. The best model including MTHFR C677T, ALOX5AP T2354A and NOTCH3 C381T scored 10 for Cross-Validation Consistency and 9 for Sign Test ( P = 0.0107). The individuals with combination of MTHFR 677TT, ALOX5AP 2354AA and NOTCH3 381TT/TC had a significantly higher risk of thrombotic stroke (OR 3.165, 95% CI 1.461–6.858, P = 0.003). Our results show that combination of these alleles conferred higher risk for stroke than single risk allele. The gene–gene interaction may serve as a novel area for stroke research. The three-locus combination may change the susceptibility of particular subjects to the disease. [ABSTRACT FROM AUTHOR]

Published
2009
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