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2. Beta-globin gene polymorphism in Saudis--triple Hpa I fragments.

Author

el-Hazmi MA, Jabbar FA, Al-Swailem AR, and Warsy AS

Subjects
Adult, Anemia, Sickle Cell blood, Anemia, Sickle Cell genetics, Crossing Over, Genetic, DNA analysis, Genes, Genetic Linkage, Hemoglobin A analysis, Hemoglobin, Sickle genetics, Humans, Male, Saudi Arabia, Globins genetics, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length
Abstract

In an attempt to investigate beta-globin gene polymorphism in the Saudi population, DNA samples were analysed using restriction endonucleases, Mst II and Hpa I. Both beta A and beta S genes showed extensive polymorphism and were found to be linked to 13.0 kb, 7.6 kb, 7.0 kb, and 5.6 kb Hpa I fragments. Three DNA samples out of a total of 436 analysed, had beta-globin gene linked to three Hpa I fragments of the sizes 13.0 kb, 7.6 kb, and 5.6 kb. In this paper we present our findings and discuss the possibility of multiple beta-globin loci.

Published
1986
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