1. Age‐dependent white matter disruptions after military traumatic brain injury: Multivariate analysis results from ENIGMA brain injury
- Author
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Bouchard, Heather C, Sun, Delin, Dennis, Emily L, Newsome, Mary R, Disner, Seth G, Elman, Jeremy, Silva, Annelise, Velez, Carmen, Irimia, Andrei, Davenport, Nicholas D, Sponheim, Scott R, Franz, Carol E, Kremen, William S, Coleman, Michael J, Williams, M Wright, Geuze, Elbert, Koerte, Inga K, Shenton, Martha E, Adamson, Maheen M, Coimbra, Raul, Grant, Gerald, Shutter, Lori, George, Mark S, Zafonte, Ross D, McAllister, Thomas W, Stein, Murray B, Thompson, Paul M, Wilde, Elisabeth A, Tate, David F, Sotiras, Aristeidis, and Morey, Rajendra A
- Subjects
Clinical and Health Psychology ,Psychology ,Traumatic Brain Injury (TBI) ,Physical Injury - Accidents and Adverse Effects ,Brain Disorders ,Traumatic Head and Spine Injury ,Neurosciences ,2.1 Biological and endogenous factors ,Brain ,Brain Concussion ,Brain Injuries ,Brain Injuries ,Traumatic ,Humans ,Military Personnel ,Multivariate Analysis ,Stress Disorders ,Post-Traumatic ,Veterans ,White Matter ,diffusion MRI ,ENIGMA ,military ,mTBI ,nonnegative matrix factorization ,traumatic brain injury ,Cognitive Sciences ,Experimental Psychology ,Biological psychology ,Cognitive and computational psychology - Abstract
Mild Traumatic brain injury (mTBI) is a signature wound in military personnel, and repetitive mTBI has been linked to age-related neurogenerative disorders that affect white matter (WM) in the brain. However, findings of injury to specific WM tracts have been variable and inconsistent. This may be due to the heterogeneity of mechanisms, etiology, and comorbid disorders related to mTBI. Non-negative matrix factorization (NMF) is a data-driven approach that detects covarying patterns (components) within high-dimensional data. We applied NMF to diffusion imaging data from military Veterans with and without a self-reported TBI history. NMF identified 12 independent components derived from fractional anisotropy (FA) in a large dataset (n = 1,475) gathered through the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) Military Brain Injury working group. Regressions were used to examine TBI- and mTBI-related associations in NMF-derived components while adjusting for age, sex, post-traumatic stress disorder, depression, and data acquisition site/scanner. We found significantly stronger age-dependent effects of lower FA in Veterans with TBI than Veterans without in four components (q
- Published
- 2022