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Start Over Author "Martinez, Marisol" Journal hospital pediatrics
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1. Factors Associated With Severe Illness in Patients Aged <21 Years Hospitalized for COVID-19

Author

Choudhary, Rewa, primary, Webber, Bryant J., additional, Womack, Lindsay S., additional, Dupont, Hannah K., additional, Chiu, Sophia K., additional, Wanga, Valentine, additional, Gerdes, Megan E., additional, Hsu, Sophia, additional, Shi, Dallas S., additional, Dulski, Theresa M., additional, Idubor, Osatohamwen I., additional, Wendel, Arthur M., additional, Agathis, Nickolas T., additional, Anderson, Kristi, additional, Boyles, Tricia, additional, Click, Eleanor S., additional, Da Silva, Juliana, additional, Evans, Mary E., additional, Gold, Jeremy A.W., additional, Haston, Julia C., additional, Logan, Pamela, additional, Maloney, Susan A., additional, Martinez, Marisol, additional, Natarajan, Pavithra, additional, Spicer, Kevin B., additional, Swancutt, Mark, additional, Stevens, Valerie A., additional, Rogers-Brown, Jessica, additional, Chandra, Gyan, additional, Light, Megan, additional, Barr, Frederick E., additional, Snowden, Jessica, additional, Kociolek, Larry K., additional, McHugh, Matthew, additional, Wessel, David L., additional, Simpson, Joelle N., additional, Gorman, Kathleen C., additional, Breslin, Kristen A., additional, DeBiasi, Roberta L., additional, Thompson, Aaron, additional, Kline, Mark W., additional, Boom, Julie A., additional, Singh, Ila R., additional, Dowlin, Michael, additional, Wietecha, Mark, additional, Schweitzer, Beth, additional, Morris, Sapna Bamrah, additional, Koumans, Emilia H., additional, Ko, Jean Y., additional, Siegel, David A., additional, and Kimball, Anne A., additional

Published
2022
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2. Factors Associated With Severe Illness in Patients Aged <21 Years Hospitalized for COVID-19

Author

Choudhary, Rewa, Webber, Bryant J., Womack, Lindsay S., Dupont, Hannah K., Chiu, Sophia K., Wanga, Valentine, Gerdes, Megan E., Hsu, Sophia, Shi, Dallas S., Dulski, Theresa M., Idubor, Osatohamwen I., Wendel, Arthur M., Agathis, Nickolas T., Anderson, Kristi, Boyles, Tricia, Click, Eleanor S., Da Silva, Juliana, Evans, Mary E., Gold, Jeremy A.W., Haston, Julia C., Logan, Pamela, Maloney, Susan A., Martinez, Marisol, Natarajan, Pavithra, Spicer, Kevin B., Swancutt, Mark, Stevens, Valerie A., Rogers-Brown, Jessica, Chandra, Gyan, Light, Megan, Barr, Frederick E., Snowden, Jessica, Kociolek, Larry K., McHugh, Matthew, Wessel, David L., Simpson, Joelle N., Gorman, Kathleen C., Breslin, Kristen A., DeBiasi, Roberta L., Thompson, Aaron, Kline, Mark W., Boom, Julie A., Singh, Ila R., Dowlin, Michael, Wietecha, Mark, Schweitzer, Beth, Morris, Sapna Bamrah, Koumans, Emilia H., Ko, Jean Y., Siegel, David A., and Kimball, Anne A.

Abstract

To describe coronavirus disease 2019 (COVID-19)–related pediatric hospitalizations during a period of B.1.617.2 (Δ) variant predominance and to determine age-specific factors associated with severe illness.We abstracted data from medical charts to conduct a cross-sectional study of patients aged <21 years hospitalized at 6 United States children’s hospitals from July to August 2021 for COVID-19 or with an incidental positive severe acute respiratory syndrome coronavirus 2 test. Among patients with COVID-19, we assessed factors associated with severe illness by calculating age-stratified prevalence ratios (PR). We defined severe illness as receiving high-flow nasal cannula, positive airway pressure, or invasive mechanical ventilation.Of 947 hospitalized patients, 759 (80.1%) had COVID-19, of whom 287 (37.8%) had severe illness. Factors associated with severe illness included coinfection with respiratory syncytial virus (RSV) (PR 3.64) and bacteria (PR 1.88) in infants; RSV coinfection in patients aged 1 to 4 years (PR 1.96); and obesity in patients aged 5 to 11 (PR 2.20) and 12 to 17 years (PR 2.48). Having ≥2 underlying medical conditions was associated with severe illness in patients aged <1 (PR 1.82), 5 to 11 (PR 3.72), and 12 to 17 years (PR 3.19).Among patients hospitalized for COVID-19, factors associated with severe illness included RSV coinfection in those aged <5 years, obesity in those aged 5 to 17 years, and other underlying conditions for all age groups <18 years. These findings can inform pediatric practice, risk communication, and prevention strategies, including vaccination against COVID-19.

Published
2022
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