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Start Over Author "Sarah Jane Schwarzenberg" Journal hormone research
5 results on '"Sarah Jane Schwarzenberg"'

1. 15th Annual Meeting of ISGD

Author

A. Berghout, Dario Giugliano, Gennaro Pizza, V. Messina, F. Mounier, J. Epelbaum, Raja Brauner, W.M. Wiersinga, A.V. Greco, T. Barreca, J. Ludvigsson, Paola Tesauw, M.T. Bluet-Pajot, Jesse Walker, Harvey L. Sharp, W.H. Brummelkamp, Tarja Porkka-Heiskanen, M. Zachmann, E.A. Werder, Saverio Sgambato, E. Rolandi, J.A. Thomson, Susan Schultz, M.A. Marini, Esther F. Freier, Göran Lindstedt, R. Rasolonjanahary, G. Ghirlanda, Leif Wide, D. Durand, Raphaël Rappaport, Lars Gelander, Felice D'Onofrio, M. Peder, Kerstin Albertsson-Wikland, M. Salvemini, Maija-Liisa Laakso, Giuseppe Paolisso, Joseph C. Dunbar, Gunnar Johansson, Sarah Jane Schwarzenberg, S.A. Santini, Gunnar Selstam, Dag Stenberg, B. Bertoli, R. Franceschini, G.H. Beastall, A. Valavanis, Steven Seelig, C. Kordon, S. Caputo, Felicia Houser, W. Wichmann, A. Cataldi, Michele Varricchio, and D. Gordon

Subjects
Gerontology, medicine.medical_specialty, Endocrinology, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Medicine, business
Published
1989

2. Contents, Vol. 31, 1989

Author

Felice D'Onofrio, Giuseppe Paolisso, A.V. Greco, M. Peder, Raphaël Rappaport, J. Epelbaum, C. Kordon, S. Caputo, Lars Gelander, Felicia Houser, G. Ghirlanda, D. Durand, Steven Seelig, Gennaro Pizza, A. Valavanis, A. Berghout, Michele Varricchio, Esther F. Freier, Göran Lindstedt, M. Salvemini, W.M. Wiersinga, Leif Wide, R. Rasolonjanahary, D. Gordon, W.H. Brummelkamp, J. Ludvigsson, Dag Stenberg, B. Bertoli, G.H. Beastall, Harvey L. Sharp, Gunnar Johansson, Saverio Sgambato, M.T. Bluet-Pajot, Jesse Walker, M.A. Marini, Paola Tesauw, S.A. Santini, A. Cataldi, E.A. Werder, Susan Schultz, J.A. Thomson, Maija-Liisa Laakso, Joseph C. Dunbar, W. Wichmann, F. Mounier, M. Zachmann, Dario Giugliano, V. Messina, T. Barreca, Sarah Jane Schwarzenberg, Raja Brauner, Gunnar Selstam, Tarja Porkka-Heiskanen, E. Rolandi, R. Franceschini, and Kerstin Albertsson-Wikland

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
1989

3. Methionyl- and pituitary derived human growth hormone have identical effects on the expression of growth hormone responsive rat hepatic mRNA

Author

Sarah Jane Schwarzenberg, Steven Seelig, and Susan A. Berry

Subjects
Hormone Responsive, Male, medicine.medical_specialty, Growth-hormone-releasing hormone receptor, Endocrinology, Diabetes and Metabolism, Biology, Gonadotropic cell, Growth hormone deficiency, Endocrinology, Thyrotropin-releasing hormone receptor, Internal medicine, medicine, Animals, Humans, RNA, Messenger, Thyroid hormone receptor, Human Growth Hormone, Rats, Inbred Strains, medicine.disease, Hormones, Recombinant Proteins, Rats, Liver, Growth Hormone, Protein Biosynthesis, Corticotropic cell, Endocrine gland
Abstract

Pituitary extracts of human growth hormone have been used extensively for therapy of growth hormone deficiency, although they are known to contain a variety of contaminating polypeptides. Biosynthetic human growth hormone is now available for this use and appears to be functionally identical in promoting growth. To establish additional criteria of identity we compared the effect of these two hormone preparations on a family of hepatic messenger RNA sequences in hypophysectomized adult male rats. Total hepatic RNA from these animals was translated in a cell-free rabbit reticulocyte lysate. Five translational products previously demonstrated to be responsive to ovine and methionyl-human growth hormone were found to be equally induced by pituitary derived human growth hormone, despite demonstrable heterogeneity in pituitary derived preparations. In addition, no significant alterations in approximately 200 non-growth hormone responsive translational products were identified. Methionyl and pituitary derived growth hormone have identical effects on the expression of hepatic mRNA.

Published
1987

4. Response of serine antiproteases to growth hormone therapy in growth hormone deficient children

Author

Sarah Jane Schwarzenberg, Esther F. Freier, Steven Seelig, and Harvey L. Sharp

Subjects
Male, medicine.medical_specialty, Serine Proteinase Inhibitors, Adolescent, alpha 1-Antichymotrypsin, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Antithrombin III, Biology, Serpin, Growth hormone, Serine, Endocrinology, Internal medicine, medicine, Gene family, Humans, Child, Gene, Chemotherapy, Antithrombin, Mrna level, Child, Preschool, Growth Hormone, alpha 1-Antitrypsin, Female, medicine.drug
Abstract

Growth hormone regulates the hepatic mRNA levels of alpha 1-antitrypsin and two contrapsin-like mRNAs in the rat. To determine whether growth hormone regulates similar serine protease inhibitors in humans, we measured serum alpha 1-antitrypsin, alpha 1-antichymotrypsin, and antithrombin III by radioimmunodiffusion in 16 growth hormone deficient children before and after growth therapy. Of the 19 determinations made, 17/19 showed an increase in alpha 1-antitrypsin after administration of growth hormone, 198.6 +/- 39.1 mg/dl before growth hormone and 239.4 +/- 44 mg/dl after growth hormone (p = 0.005). Specificity of the response for alpha 1-antitrypsin was indicated by the fact that neither alpha 1-antichymotrypsin or antithrombin III values changed after growth hormone (p = 0.6 and 0.5, respectively). These data are compatible with the hypothesis that growth hormone regulates serine protease inhibitors in humans and suggests that investigation of other members of the serpin gene family might prove fruitful in defining additional growth hormone target genes.

Published
1989

5. Subject Index, Vol. 31, 1989

Author

Harvey L. Sharp, Dario Giugliano, W.H. Brummelkamp, A.V. Greco, J. Epelbaum, V. Messina, F. Mounier, Dag Stenberg, B. Bertoli, M.T. Bluet-Pajot, Jesse Walker, M. Zachmann, Raphaël Rappaport, W.M. Wiersinga, J.A. Thomson, M. Peder, A. Cataldi, T. Barreca, M.A. Marini, G. Ghirlanda, D. Durand, M. Salvemini, A. Berghout, Tarja Porkka-Heiskanen, Kerstin Albertsson-Wikland, Maija-Liisa Laakso, Saverio Sgambato, C. Kordon, E. Rolandi, R. Rasolonjanahary, Susan Schultz, Felice D'Onofrio, S. Caputo, Joseph C. Dunbar, Giuseppe Paolisso, Gunnar Johansson, R. Franceschini, W. Wichmann, Paola Tesauw, E.A. Werder, Gunnar Selstam, Lars Gelander, A. Valavanis, Sarah Jane Schwarzenberg, Raja Brauner, J. Ludvigsson, S.A. Santini, Gennaro Pizza, Leif Wide, Esther F. Freier, Göran Lindstedt, D. Gordon, Steven Seelig, Felicia Houser, Michele Varricchio, and G.H. Beastall

Subjects
Endocrinology, Index (economics), Endocrinology, Diabetes and Metabolism, Statistics, Subject (documents), Mathematics
Published
1989

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