1. Growth hormone secretion after baclofen administration in different phases of the menstrual cycle in healthy women.
- Author
-
Orio F Jr, Palomba S, Colao A, Tenuta M, Dentico C, Petretta M, Lombardi G, Nappi C, and Orio F
- Subjects
- Administration, Oral, Adult, Baclofen pharmacology, Female, Follicular Phase drug effects, GABA Agonists administration & dosage, GABA Agonists pharmacology, Growth Hormone blood, Humans, Luteal Phase drug effects, Menstrual Cycle blood, Ovulation drug effects, Baclofen administration & dosage, Growth Hormone metabolism, Menstrual Cycle drug effects
- Abstract
Aim: The aim of this study was to investigate the effect of baclofen administration on growth hormone (GH) secretion during different phases of the menstrual cycle., Methods: Twelve healthy women (33.6 +/- (SD) 2.8 years; range 23-40 years) with regular menstrual cycles were enrolled. The phases of the menstrual cycle were determined using transvaginal ultrasonography (TV-US) and detecting hormonal serum levels. Plasma GH levels were evaluated during the early follicular, periovulatory and luteal phases of the cycle before and after the baclofen challenge test., Results: After acute baclofen administration, GH levels increased significantly (p < 0.001) compared to basal values during the periovulatory and luteal phases, while no significant variation was detected during the early follicular phase. In addition, plasma GH levels resulted significantly (p < 0.001) higher during the luteal phase than during the periovulatory phase., Conclusion: Acute baclofen administration induces a significant increase in plasma GH levels in healthy females during the periovulatory and luteal phases, but not during the early follicular phase. These data suggest a modulator role of plasma sex steroids levels on GH release induced by baclofen., (Copyright 2001 S. Karger AG, Basel)
- Published
- 2001
- Full Text
- View/download PDF