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Start Over Author "Eric, Clauser" Journal hormone research
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1. Contents, Vol. 47, 1997

Author

P. Chanson, X. Jeunemaitre, M. Talbot, D. Simpson, Emmanuel Gautherot, Annick Martin, Maria Luisa Brandi, Jp. Aubert, Catharina Larsson, F. Mantero, Cx. Zhang, David Wynford-Thomas, Claude Jaffiol, M. Boggild, Simona Mantovani, A.M. Masini, Eric Clauser, A. Angeli, Véronique Alvaro, Cristina Missale, G. Gunz, B. Fournes, A. Enjalbert, Olov Nilsson, I. Morange-Ramos, Charis Eng, B. Conte-Devolx, A. Courseaux, Eric Rouvier, A. Murat, Lars-Ove Farnebo, Alessandra Finardi, Filip Farnebo, G. Cadiot, P. Niccoli, B. Allolio, C. Beldjord, Massimo Giovanelli, Colette Auzan, P. Jaquet, P. Gaudray, Corinne Prévostel, Chiara Fiorentini, A. Ali, M. Giovagnetti, Pascal Meyer, R. Monier, B. Maes, Marco Losa, M. Terzolo, V. Aubert, Xavier Bertagna, Sandra Sigala, J.F. Hewy, W. Farrell, G. Arnaldi, M. Klein, A. Calender, J. Leclère, Jérôme Bertherat, Frederic Lenne, G. Osella, Patricia René, J. Bicknell, Andrea Lania, N. Porchet, Pf. Plouin, C. Gicquel, M.C. Béné, A. Barlier, Lois M. Mulligan, A. Boneu, L. Caccavelli, B. Caillou, Anna Spada, P. Rochefort, G. Opocher, G. Faure, Jacques Barbel, S. Giraud, Deborah J. Marsh, F. Michiels, Johannes Järhult, P. Rodien, Jacob Lagercrantz, Bin Tean Teh, J. Feunteun, G. Weryha, Dominique Joubert, M. Reincke, I. Schuffenecker, J.B. Corcuff, L. Mercken, Kerstin Sandelin, C. Dumont, M. Schlumberger, Y. Le Bouc, E. Modigliani, Yves de Keyzer, V. Pascal-Vigneron, Emilia Ballaré, Günther Weber, A.S. Bates, R.N. Clayton, I. Pellegrini-Bouiller, PierFranco Spano, N. Barbot, and Gm. Lenoir

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
1997
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2. V3 Vasopressin Receptor and Corticotropic Phenotype in Pituitary and Nonpituitary Tumors

Author

P René, Eric Clauser, Xavier Bertagna, F Lenne, Y. De Keyzer, and C. Auzan

Subjects
Arginine vasopressin receptor 1B, Receptors, Vasopressin, endocrine system, medicine.medical_specialty, Vasopressin, Corticotropin secretion, Endocrinology, Diabetes and Metabolism, Gene Expression, Biology, Phenotype, Endocrinology, Adrenocorticotropic Hormone, Pituitary Gland, Internal medicine, Arginine vasopressin receptor 2, medicine, Humans, Pituitary Neoplasms, ACTH receptor, RNA, Messenger, Receptor, hormones, hormone substitutes, and hormone antagonists, Vasopressin receptor
Abstract

Pituitary corticotropic cells express a specific vasopressin receptor, called V1b or V3, through which vasopressin stimulates corticotropin secretion. We recently cloned a cDNA coding for this receptor and showed that it belongs to the G protein-coupled receptor family. V3 mRNA is readily detected by RT-PCR in normal human pituitaries and corticotropic pituitary adenomas but not in PRL or GH-secreting adenomas, thus demonstrating that, like POMC itself and the CRH receptor, V3 is a marker of the corticotropic phenotype. Nuclease protection experiments suggest that V3 is overexpressed in some corticotropic adenomas, and thus may play a role in tumor development by activating the phospholipase C-signalling pathway. In addition analysis of its expression in nonpituitary neuroendocrine tumors showed a striking association with carcinoids of the lung responsible for the ectopic ACTH syndrome.

Published
1997
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3. Molecular Resistance is of Insulin

Author

C. Auzan, Eric Clauser, and I. Leconte

Subjects
Genetics, Mutation, biology, Glucokinase, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Glucose transporter, medicine.disease, medicine.disease_cause, Insulin receptor, Endocrinology, Insulin resistance, medicine, biology.protein, Gene, GLUT4
Abstract

The recent application of recombinant DNA technology to clinical investigation now allows the identification of the molecular alterations responsible for insulin resistance. In this review, the recent knowledge concerning these investigations is reported. Genetic mutations of the insulin gene as the source of insulin resistance have been reported for a long time. More recently a series of mutations of the insulin receptor gene have been identified as the cause of the extreme insulin resistance, observed in rare syndromes, such as type A insulin resistance or leprechaunism. However, it is probable that the majority of the molecular defects causing insulin resistance occur at the postreceptor level. The key proteins involved in the different intracellular signalling pathways of insulin are only partly identified. A better understanding of the mechanisms of insulin action is essential for the identification of corresponding genetic alterations. The investigations concerning the glucose transporter GLUT4 and glucokinase genes are good examples of complex but promising research, which has recently started. Elucidation of the genetic and molecular basis of diseases such as type II diabetes or other states associated with insulin resistance, is the long-term goal.

Published
1992
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4. The Difficult Challenge of Cloning the Angiotensin II Receptor

Author

Claire Bihoreau, Eric Clauser, V. Weber, Pierre Corvol, and Catherine Monnot

Subjects
medicine.medical_specialty, Angiotensin receptor, Receptors, Angiotensin, Angiotensin II receptor type 1, Chemistry, G protein, Endocrinology, Diabetes and Metabolism, Molecular cloning, Pharmacology, Angiotensin II, Rats, Xenopus laevis, Endocrinology, Internal medicine, medicine, Animals, Rabbits, Cloning, Molecular, Receptor, Protease-activated receptor 2, Glucagon-like peptide 1 receptor
Abstract

The vasopressor peptide angiotensin II exerts its cellular effects through a membrane-bound receptor coupled to a G protein. Biochemical and pharmacological analyses of this receptor already identify two different membrane-bound receptors and one cytosoluble angiotensin-II-binding protein. Nevertheless, the purification of the membrane-bound form(s) appears to be difficult. In the absence of purified protein, two cloning strategies of the gene have been explored: (1) expression cloning, identifying the functions of the protein expressed from a cDNA library in COS cells or Xenopus oocytes, has been unsuccessful until now; (2) analogical cloning, trying to identify related members of the seven transmembrane segment receptor family, which could be related to angiotensin receptors, identifies the mas oncogene and two related genes. However, there are accumulating data to exclude their involvement in angiotensin binding.

Published
1990
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5. Subject Index Vol. 47, 1997

Author

C. Beldjord, Colette Auzan, Pf. Plouin, Chiara Fiorentini, Charis Eng, A.M. Masini, A. Boneu, G. Faure, Claude Jaffiol, M. Boggild, Deborah J. Marsh, F. Michiels, S. Giraud, Simona Mantovani, Eric Clauser, A.S. Bates, Yves de Keyzer, P. Gaudray, V. Pascal-Vigneron, Jacques Barbel, J. Feunteun, I. Morange-Ramos, A. Angeli, Andrea Lania, Emilia Ballaré, M. Reincke, Corinne Prévostel, PierFranco Spano, N. Barbot, Dominique Joubert, I. Schuffenecker, N. Porchet, V. Aubert, Xavier Bertagna, R. Monier, B. Maes, Jacob Lagercrantz, M.C. Béné, M. Giovagnetti, Marco Losa, Lois M. Mulligan, Bin Tean Teh, G. Gunz, M. Terzolo, A. Enjalbert, A. Courseaux, Johannes Järhult, Y. Le Bouc, M. Klein, Emmanuel Gautherot, F. Mantero, Lars-Ove Farnebo, B. Fournes, Günther Weber, E. Modigliani, Catharina Larsson, Jérôme Bertherat, B. Caillou, Sandra Sigala, Véronique Alvaro, W. Farrell, Jp. Aubert, A. Calender, Cx. Zhang, Gm. Lenoir, G. Osella, Anna Spada, A. Murat, J.B. Corcuff, C. Gicquel, L. Caccavelli, G. Opocher, A. Martin, P. Rochefort, Massimo Giovanelli, B. Conte-Devolx, Cristina Missale, Pascal Meyer, Alessandra Finardi, Filip Farnebo, J. Leclère, P. Niccoli, J. Bicknell, B. Allolio, J.F. Hewy, P. Jaquet, Patricia René, A. Ali, A. Barlier, R.N. Clayton, I. Pellegrini-Bouiller, Maria Luisa Brandi, David Wynford-Thomas, Olov Nilsson, C. Dumont, M. Schlumberger, G. Arnaldi, L. Mercken, Kerstin Sandelin, P. Chanson, X. Jeunemaitre, M. Talbot, D. Simpson, P. Rodien, Frederic Lenne, G. Weryha, Eric Rouvier, and G. Cadiot

Subjects
Endocrinology, Index (economics), Endocrinology, Diabetes and Metabolism, Statistics, Subject (documents), Mathematics
Published
1997
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