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This finding suggests a collision of metastatic thyroid papillary carcinoma and lung adenocarcinoma, because the morphological features were different between the adenocarcinoma-like tumour (C, lower half) and the metastatic papillary carcinoma (C, upper half). A pleural nodule was found to be adhering to the surface of the resected lower lobe specimen; the nodule was composed of adenocarcinoma, so pleural dissemination of lung adenocarcinoma was suspected. The marked small nodule adjacent to the primary tumour was a small metastasis of papillary thyroid carcinoma, and similar nodules were scattered in the outside lung parenchyma. [Extracted from the article]

Aims Methods and Results Conclusion The PEComa family of tumours is defined by spindle/epithelioid cells with myomelanocytic differentiation. A small subset harbours TFE3 fusion; however, YAP1::TEE3 has not been reported. Clear cell stromal tumour of the lung (CCST‐L) is an emerging entity characterized by spindle to epithelioid cells with focal cytoplasmic clearing, inflammatory infiltrates, no myomelanocytic differentiation, and YAP1::TFE3 fusion. Herein, we report two cases of lung tumours with myomelanocytic differentiation that showed inflammatory spindle cell histology, focal epithelioid clear cells, as well as YAP1::TFE3 fusion.The patients were both men, aged 61 and 68 years. The tumours in both cases presented as well‐circumscribed solid masses involving the lung hilum. After lobectomy, no recurrence was observed at 7 and 32 months. Both tumours shared storiform to short fascicular growth of long spindle cells, with a minor component of epithelioid cells showing clear cytoplasm in the background of substantial intratumoral chronic inflammation and dilated blood vessels. One tumour showed focal melanin deposition. Both tumours were immunohistochemically positive for HMB45, Melan A, and h‐caldesmon. Fluorescence in situ hybridization assays indicated the presence of YAP1::TFE3 fusions, which was confirmed by RNA sequencing in one case tested, and by immunohistochemical TFE3 expression and loss of YAP1 C‐terminus staining.We present two cases of inflammatory spindle to epithelioid cell tumours of the lungs with myomelanocytic differentiation and YAP1::TFE3 fusion. This unique morphology and gene fusion suggest that these tumours may constitute a distinct subset of lung PEComa. Furthermore, morphological and molecular overlap with CCST‐L gives rise to a hypothesis of a potential inherent relationship between PEComa and CCST‐L. [ABSTRACT FROM AUTHOR]