1. Peripheral T-cell lymphomas: an evaluation of reproducibility of the updated Kiel classification
- Author
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N. Hastrup, Stephen Hamilton-Dutoit, Gorm Pallesen, and E. Ralfkiaer
- Subjects
Pathology ,medicine.medical_specialty ,Histology ,T cell ,Statistics as Topic ,Haematoxylin ,Giemsa stain ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,hemic and lymphatic diseases ,medicine ,Humans ,Observer Variation ,Reproducibility ,Frozen section procedure ,business.industry ,Lymphoma, Non-Hodgkin ,Lymphoma, T-Cell, Peripheral ,Reproducibility of Results ,General Medicine ,medicine.disease ,Lymphoma ,Peripheral ,medicine.anatomical_structure ,chemistry ,business - Abstract
Haematoxylin and eosin, and Giemsa stained sections from 100 peripheral T-cell lymphomas were examined blind on two occasions by four experienced haematopathologists in order to evaluate the inter- and intra-observer reproducibility of the updated Kiel classification for these malignancies. In all cases, the T-cell phenotype had been established previously in frozen section using a panel of monoclonal antibodies. Analysis by kappa statistics showed poor reproducibility, both overall and for most subtypes, with the exception of large cell anaplastic lymphoma. The distinction between low- and high-grade lymphomas was also unsatisfactory. These results indicate the need for improved precision in the definition of histological categories of peripheral T-cell lymphoma. The reproducibility of the updated Kiel classification for peripheral T-cell lymphomas in its present form is inadequate.
- Published
- 1991