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Using data on the patent portfolios of UK universities, the paper compares the levels of patenting activity (filings), success (grants) and quality (patents with commercial co-assignees and patent citations) at Welsh, Scottish and Northern Irish institutions. Patent activity, per researcher, in Wales is on a par with that in Scotland and about twice the rate in Northern Ireland, but the numbers of researchers relative to population in Wales and Northern Ireland are around half of the number in Scotland. Patent quality indicators are less favourable to Wales, while both activity levels and conversion of applications into grants are poor in Northern Ireland. It is suggested that greater cross-university collaboration in Wales and Northern Ireland would help improve performance.