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10 results on '"Midori A. Arai"'

8. Synthesis and Evaluation of Isomers of Melleumin B from the Myxomycete Physarum melleum; an Approach for Wnt Signal Inhibitor Trusted in Nature

Author

Shuwa Hanazawa, Midori A. Arai, Xiaofan Li, Yujiro Uchino, Naoki Kimura, and Masami Ishibashi

Subjects
Pharmacology, chemistry.chemical_classification, Biochemistry, Chemistry, Transcription (biology), Organic Chemistry, Physarum melleum, Wnt signaling pathway, Melleumin B, Peptide, Analytical Chemistry
Abstract

Γwo stereoisomers of melleumin B (1), seco acid methyl ester of melleumin A (2), which are novel peptide compounds isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R, 4S, 10R, 11R)-isomer of 1 showed moderate inhibition of the Wnt signal.

Published
2008

9. Synthesis of 25-Hydroxy-19-norvitamin D3 Analogs and Their Antiproliferative Activities on Prostate Cells

Author

Atsushi Kittaka, Tai C. Chen, Kuniyo Inouye, Hideki Hara, Midori A. Arai, Naoko Urushino, Toshiyuki Sakaki, and Ryuji Tsutsumi

Subjects
Pharmacology, Stereochemistry, Chemistry, Organic Chemistry, Prohormone, Analytical Chemistry, law.invention, Biochemistry, Prostate cell, law, Recombinant DNA, medicine, medicine.drug, Prostate cells
Abstract

Synthesis of 25-hydroxy-19-norvitamin D 3 derivatives as prohormone type agents for anti-prostate diseases was accomplished utilizing Julia-type olefination. Synthesized compounds showed potent antiproliferative activity on an immortalized normal prostate cell line, PZ-HPV-7, which has high la-hydroxylase activity. Furthermore, we demonstrated that 25-hydroxy-19-norvitamin D 3 was hydroxylated at the la position to form la,25-dihydroxy-19-norvitamin D 3 by a recombinant human la-hydroxylase (CYP27B1) in a cell-free system.

Published
2005

10. Spiro Bis(isoxazole) as a New Chiral Ligand

Author

Kazuhiko Wakita, Hiroaki Sasai, Midori A. Arai, Toshio Shinohara, and Takahiro Kato

Subjects
Pharmacology, Stereochemistry, Chemistry, Ligand, Organic Chemistry, Chiral ligand, Enantioselective synthesis, chemistry.chemical_element, General Medicine, Analytical Chemistry, chemistry.chemical_compound, Isoxazole, Chirality (chemistry), Palladium
Abstract

A novel bis(isoxazole) ligand, (M*)-4,4',5,5',6,6',7,7'-octahydro-7,7'-spirobi[benzo[c]isoxazole] (5) bearing a spiro chirality was designed and synthesized. Characterization of the ligand and its application to the enantioselective tandem cyclizaton of alkenyl alcohol via oxy-palladation are described.

Published
2004

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