1. Genomic Evolution of the Distal Mhc Class I Region on Mouse Chr 17
- Author
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Elsy P. Jones, Hong Xiao, Kirsten Fischer Lindahl, Claire Amadou, Attila Kumánovics, and Masayasu Yoshino
- Subjects
Genetics ,Models, Genetic ,Contig ,Breakpoint ,MHC Class I Gene ,Chromosome Mapping ,Genes, MHC Class I ,Chromosome ,General Medicine ,Biology ,Major histocompatibility complex ,Evolution, Molecular ,Mice ,Conserved Synteny ,Species Specificity ,Multigene Family ,Chromosome Inversion ,MHC class I ,biology.protein ,Animals ,Humans ,Chromosomes, Artificial, Yeast ,Gene - Abstract
A 5-Mb YAC contig, partly supplemented with BAC contigs, was created from the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M region is rich in L1 repeats, implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.
- Published
- 2004