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Start Over Author "Takeharu Yamamoto" Journal hepatology research
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1. Indices of initial hepatitis C virus RNA reduction rate to predict efficacy of interferon-beta followed by peginterferon plus ribavirin for genotype 1b high viral load

Author

Hiroshi Kishida, Takeharu Yamamoto, Koichi Uesaka, Kazuhiko Morii, and Hiroaki Okushin

Subjects
medicine.medical_specialty, Hepatology, business.industry, Ribavirin, Hepatitis C virus, Reduction rate, virus diseases, RNA, medicine.disease_cause, Gastroenterology, Virology, digestive system diseases, chemistry.chemical_compound, Infectious Diseases, chemistry, Genotype 1b, Interferon, Hepatitis C virus RNA, Internal medicine, medicine, business, Viral load, medicine.drug
Abstract

Aim Initial hepatitis C virus (HCV) RNA reduction was investigated as a potential index for sustained virological response (SVR) in the treatment of interferon (IFN)-β followed by peginterferon plus ribavirin (PEG IFN/RBV). Methods The treatment course was retrospectively analyzed in 64 genotype 1b patients with a HCV RNA level of 5.0 logIU/mL or higher. IFN-β was administrated twice a day for 2 weeks followed by 24 or 48 weeks of PEG IFN/RBV. The serum HCV RNA level was measured by real-time polymerase chain reaction before administration and at 1, 2 and 4 weeks of therapy. Results By the duration of PEG IFN administration, the SVR rates were 11% (2/18

Published
2013
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