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Your search keyword '"Sakhuja P"' showing total 11 results
Start Over Author "Sakhuja P" Journal hepatology international
11 results on '"Sakhuja P"'

1. Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

Author

Shiha, Gamal, Ibrahim, Alaa, Helmy, Ahmed, Sarin, Shiv Kumar, Omata, Masao, Kumar, Ashish, Bernstien, David, Maruyama, Hitushi, Saraswat, Vivek, Chawla, Yogesh, Hamid, Saeed, Abbas, Zaigham, Bedossa, Pierre, Sakhuja, Puja, Elmahatab, Mamun, Lim, Seng Gee, Lesmana, Laurentius, Sollano, Jose, Jia, Ji-Dong, Abbas, Bahaa, Omar, Ashraf, Sharma, Barjesh, Payawal, Diana, Abdallah, Ahmed, Serwah, Abdelhamid, Hamed, Abdelkhalek, Elsayed, Aly, AbdelMaqsod, Amany, Hassanein, Tarek, Ihab, Ahmed, GHaziuan, Hamsik, Zein, Nizar, and Kumar, Manoj

Published
2017
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5. Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)

Author

Shiha, Gamal, Sarin, Shiv Kumar, Ibrahim, Alaa Eldin, Omata, Masao, Kumar, Ashish, Lesmana, Laurentius A., Leung, Nancy, Tozun, Nurdan, Hamid, Saeed, Jafri, Wasim, Maruyama, Hitoshi, Bedossa, Pierre, Pinzani, Massimo, Chawla, Yogesh, Esmat, Gamal, Doss, Wahed, Elzanaty, Taher, Sakhuja, Puja, Nasr, Ahmed Medhat, Omar, Ashraf, Wai, Chun-Tao, Abdallah, Ahmed, Salama, Mohsen, Hamed, Abdelkhalek, Yousry, Ayman, Waked, Imam, Elsahar, Medhat, Fateen, Amr, Mogawer, Sherif, Hamdy, Hassan, Elwakil, Reda, and Jury of the APASL Consensus Development Meeting 29 January 2008 on Liver Fibrosis With Without Hepatitis B or C

Published
2009
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6. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)

Author

Sarin, Shiv Kumar, Kumar, Ashish, Almeida, John A., Chawla, Yogesh Kumar, Fan, Sheung Tat, Garg, Hitendra, de Silva, H. Janaka, Hamid, Saeed Sadiq, Jalan, Rajiv, Komolmit, Piyawat, Lau, George K., Liu, Qing, Madan, Kaushal, Mohamed, Rosmawati, Ning, Qin, Rahman, Salimur, Rastogi, Archana, Riordan, Stephen M., Sakhuja, Puja, Samuel, Didier, Shah, Samir, Sharma, Barjesh Chander, Sharma, Praveen, Takikawa, Yasuhiro, Thapa, Babu Ram, Wai, Chun-Tao, and Yuen, Man-Fung

Published
2009
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7. Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver

Author

Sarin, Shiv Kumar, Kumar, Ashish, Angus, Peter W., Baijal, Sanjay Saran, Chawla, Yogesh Kumar, Dhiman, Radha Krishna, Janaka de Silva, H., Hamid, Saeed, Hirota, Shozo, Hou, Ming-Chih, Jafri, Wasim, Khan, Mobin, Lesmana, Laurentius A., Lui, Hock F., Malhotra, Veena, Maruyama, Hitoshi, Mazumder, Debendranath Guha, Omata, Masao, Poddar, Ujjal, Puri, Amrinder S., Sharma, Praveen, Qureshi, Huma, Raza, Rizvi Moattar, Sahni, Peush, Sakhuja, Puja, Salih, Mohammad, Santra, Amal, Sharma, Barjesh Chander, Shah, Hasnain Ali, Shiha, Gamal, Sollano, Jose, and APASL Working Party on Portal Hypertension

Published
2008
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8. Noncirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment

Author

Sarin, Shiv Kumar, Kumar, Ashish, Chawla, Yogesh Kumar, Baijal, Sanjay Saran, Dhiman, Radha Krishna, Jafri, Wasim, Lesmana, Laurentius A, Guha Mazumder, Debendranath, Omata, Masao, Qureshi, Huma, Raza, Rizvi Moattar, Sahni, Peush, Sakhuja, Puja, Salih, Mohammad, Santra, Amal, Sharma, Barjesh Chander, Sharma, Praveen, Shiha, Gamal, Sollano, Jose, and Members of the APASL Working Party on Portal Hypertension

Published
2007
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9. Correction to: Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.

Author

Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, and Yoon EL

Abstract

The article Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update, written by [Shiv Sarin], was originally published electronically on the publisher's internet portal (currently SpringerLink) on June 06, 2019 without open access.

Published
2019
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10. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.

Author

Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, and Yoon EL

Subjects
Acute Kidney Injury etiology, Acute-On-Chronic Liver Failure diagnosis, Acute-On-Chronic Liver Failure etiology, Blood Coagulation Disorders etiology, Chemical and Drug Induced Liver Injury etiology, Child, Diagnosis, Differential, Esophageal and Gastric Varices etiology, Gastrointestinal Hemorrhage etiology, Hepatic Encephalopathy etiology, Hepatitis, Autoimmune etiology, Hepatitis, Viral, Human prevention & control, Humans, Liver Transplantation methods, Non-alcoholic Fatty Liver Disease etiology, Obesity complications, Practice Guidelines as Topic, Prognosis, Sepsis etiology, Acute-On-Chronic Liver Failure therapy
Abstract

The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the "APASL ACLF Research Consortium (AARC)" was formed in 2012, which continued to collect prospective ACLF patient data. Based on the prospective data analysis of nearly 1400 patients, the AARC consensus was published in 2014. In the past nearly four-and-a-half years, the AARC database has been enriched to about 5200 cases by major hepatology centers across Asia. The data published during the interim period were carefully analyzed and areas of contention and new developments in the field of ACLF were prioritized in a systematic manner. The AARC database was also approached for answering some of the issues where published data were limited, such as liver failure grading, its impact on the 'Golden Therapeutic Window', extrahepatic organ dysfunction and failure, development of sepsis, distinctive features of acute decompensation from ACLF and pediatric ACLF and the issues were analyzed. These initiatives concluded in a two-day meeting in October 2018 at New Delhi with finalization of the new AARC consensus. Only those statements, which were based on evidence using the Grade System and were unanimously recommended, were accepted. Finalized statements were again circulated to all the experts and subsequently presented at the AARC investigators meeting at the AASLD in November 2018. The suggestions from the experts were used to revise and finalize the consensus. After detailed deliberations and data analysis, the original definition of ACLF was found to withstand the test of time and be able to identify a homogenous group of patients presenting with liver failure. New management options including the algorithms for the management of coagulation disorders, renal replacement therapy, sepsis, variceal bleed, antivirals and criteria for liver transplantation for ACLF patients were proposed. The final consensus statements along with the relevant background information and areas requiring future studies are presented here.

Published
2019
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11. Peroxisome proliferators-activated receptor γ2 Pro12Ala variant is associated with body mass index in non-alcoholic fatty liver disease patients.

Author

Gupta AC, Chaudhory AK, Sukriti, Pande C, Sakhuja P, Singh Y, Basir SF, and Sarin SK

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease globally and commonly associated with insulin resistance and metabolic syndrome (MS). Peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor abundantly expressed in adipocytes and plays a key role in the regulation of adipocyte differentiation, lipid and glucose homeostasis. Pro12Ala variant has been earlier associated with obesity, type 2 diabetes and MS., Aim: The present study aimed to determine the genotype frequencies of the Pro12Ala variant in NAFLD patients and any further association with other phenotype in the patients., Patients and Methods: Ninety-eight NAFLD patients and 280 matched controls were genotyped for presence of the Pro12Ala variant. Genomic DNA was extracted and polymerase chain reaction-restriction fragment length polymorphism using Bst-UI was performed for the detection of C-G change at codon 12 position of PPAR γ2 gene. Genotype and allele frequencies were compared between patients and controls. The Hardy-Weinberg equilibrium was tested by comparing expected/observed genotype frequencies by χ(2) test., Results: The frequencies of Pro/Ala genotype were comparable between NAFLD patients and controls. In the controls, 213 (75.7%) were homozygous for the wild-type (Pro/Pro) genotype and 67 (23.9%) were heterozygous (Pro/Ala). In NAFLD patients, genotypic distribution of wild type, heterozygous and homozygous were 63 (64.3%), 34 (34.7%) and 1 (1%), respectively. Heterozygous genotype was found to be significantly higher in the patients (P = 0.01). We also analyzed related phenotypic association of the patients with Pro12Ala genotype. We observed that the Pro12Ala (heterozygous) genotype was significantly higher in the patients who had body mass index >25 kg/m(2) (P = 0.025)., Conclusions: Pro12Ala variation of the PPAR γ2 gene is associated with NAFLD and might play a role in the pathogenesis of NAFLD.

Published
2010
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