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Your search keyword '"Sabrina Quek"' showing total 2 results
Start Over Author "Sabrina Quek" Journal hepatology international
2 results on '"Sabrina Quek"'

1. Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study

Author

Masaru Enomoto, Sang Bong Ahn, Chao Wu, Dae Won Jun, Jae Yoon Jeong, Li Liu, Htet Htet Toe Wai Khine, Lung-Yi Mak, Ming-Lun Yeh, Rui Huang, Mindie H. Nguyen, Seng Gee Lim, Chien-Hung Chen, Soung Won Jeong, Chia-Yen Dai, Jee-Fu Huang, Hyunwoo Oh, Sung Eun Kim, Wan-Long Chuang, Vivien W.M. Tsui, Rex Wan-Hin Hui, Dong Hyun Lee, Sabrina Quek, Ramsey Cheung, Man-Fung Yuen, Pei-Chien Tsai, Allen Dao, Eileen Yoon, Grace Lai-Hung Wong, Chung-Feng Huang, Daniel Q. Huang, Ritsuzo Kozuka, Yong Kyun Cho, Eiichi Ogawa, Joseph Hoang, Jae-Jun Shim, Lindsey Trinh, Qing Xie, Ming-Lung Yu, Cheng Yuan Peng, Hyoung Su Kim, and Huy N. Trinh

Subjects
medicine.medical_specialty, Hepatology, Proportional hazards model, business.industry, Incidence (epidemiology), Urology, Renal function, Retrospective cohort study, Entecavir, medicine.disease, Internal medicine, Cohort, medicine, business, Kidney disease, medicine.drug
Abstract

We aimed to compare the longitudinal changes in estimated glomerular filtration rate (eGFR) in chronic hepatitis B (CHB) patients treated with entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF). This is a retrospective study of 6189 adult treatment-naive CHB patients initiated therapy with TDF (n = 2482) or ETV (n = 3707) at 25 international centers using multivariable generalized linear modeling (GLM) to determine mean eGFR (mL/min/1.73 m2) and Kaplan–Meier method to estimate incidence of renal impairment (≥ 1 chronic kidney disease [CKD] stage worsening). We also examined above renal changes in matched ETV and TDF patients (via propensity score matching [PSM] on age, sex, diabetes mellitus [DM], hypertension [HTN], cirrhosis, baseline eGFR, and follow-up duration). In the overall cohort (mean age 49.7 years, 66.2% male), the baseline eGFR was higher for TDF vs. ETV group (75.9 vs. 74.0, p = 0.009). PSM yielded 1871 pairs of ETV or TDF patients with baseline eGFR ≥ 60 and 520 pairs for the eGFR

Published
2021
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2. Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study

Author

Lung-Yi, Mak, Joseph, Hoang, Dae Won, Jun, Chien-Hung, Chen, Cheng-Yuan, Peng, Ming-Lun, Yeh, Sung Eun, Kim, Daniel Q, Huang, Jae Yoon, Jeong, Eileen, Yoon, Hyunwoo, Oh, Pei-Chien, Tsai, Chung-Feng, Huang, Sang Bong, Ahn, Huy, Trinh, Qing, Xie, Grace L H, Wong, Masaru, Enomoto, Jae-Jun, Shim, Dong-Hyun, Lee, Li, Liu, Ritsuzo, Kozuka, Yong Kyun, Cho, Soung Won, Jeong, Hyoung Su, Kim, Lindsey, Trinh, Allen, Dao, Rui, Huang, Rex Wan-Hin, Hui, Vivien, Tsui, Sabrina, Quek, Htet Htet Toe Wai, Khine, Eiichi, Ogawa, Chia Yen, Dai, Jee Fu, Huang, Ramsey, Cheung, Chao, Wu, Wan-Long, Chuang, Seng Gee, Lim, Ming-Lung, Yu, Man-Fung, Yuen, and Mindie H, Nguyen

Subjects
Adult, Male, Guanine, Hepatitis B, Chronic, Treatment Outcome, Humans, Female, Middle Aged, Kidney, Tenofovir, Antiviral Agents, Retrospective Studies
Abstract

We aimed to compare the longitudinal changes in estimated glomerular filtration rate (eGFR) in chronic hepatitis B (CHB) patients treated with entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF).This is a retrospective study of 6189 adult treatment-naïve CHB patients initiated therapy with TDF (n = 2482) or ETV (n = 3707) at 25 international centers using multivariable generalized linear modeling (GLM) to determine mean eGFR (mL/min/1.73 mIn the overall cohort (mean age 49.7 years, 66.2% male), the baseline eGFR was higher for TDF vs. ETV group (75.9 vs. 74.0, p = 0.009). PSM yielded 1871 pairs of ETV or TDF patients with baseline eGFR ≥ 60 and 520 pairs for the eGFR 60 group. GLM analysis of the overall (unmatched) cohort and PSM cohorts revealed lower adjusted mean eGFRs in TDF (vs. ETV) patients (all p 0.01) during 10 years of follow-up. Among PSM eGFR ≥ 60 patients, the 5-year cumulative incidences of renal impairment were 42.64% for ETV and 48.03% for TDF (p = 0.0023). In multivariable Cox regression, TDF vs. ETV (adjusted HR 1.26, 95% CI 1.11-1.43) was associated with higher risk of worsening renal function.Over the 10-year study follow-up, compared to ETV, TDF was associated with a lower mean eGFR and higher incidence of renal impairment.

Published
2021

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