1. Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease
- Author
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Daniel H, Leung, Sridevi, Devaraj, Nathan P, Goodrich, Xinpu, Chen, Deepthi, Rajapakshe, Wen, Ye, Victor, Andreev, Charles G, Minard, Danielle, Guffey, Jean P, Molleston, Lee M, Bass, Saul J, Karpen, Binita M, Kamath, Kasper S, Wang, Shikha S, Sundaram, Philip, Rosenthal, Patrick, McKiernan, Kathleen M, Loomes, M Kyle, Jensen, Simon P, Horslen, Jorge A, Bezerra, John C, Magee, Robert M, Merion, Ronald J, Sokol, and Benjamin L, Shneider
- Subjects
Article - Abstract
BACKGROUND & AIMS: Detailed investigation of the biological pathways leading to hepatic fibrosis and identification of liver fibrosis biomarkers may facilitate early interventions for pediatric cholestasis. APPROACH & RESULTS: A targeted ELISA-based panel of 9 biomarkers (lysyl oxidase (LOX), tissue inhibitor matrix metalloproteinase 1 (TIMP1), connective tissue growth factor (CTGF), interleukin-8 (IL-8), endoglin, periostin, mac-2-binding protein (mac2-BP), matrix metalloproteinase-3 and −7 (MMP-3, MMP-7) was examined in children with biliary atresia (BA, n=187), alpha-1 antitrypsin deficiency (A1AT, n=78) and Alagille syndrome (ALGS, n=65) and correlated with liver stiffness (LSM) and biochemical measures of liver disease. Median age and LSM were 9 years and 9.5 kPa. After adjusting for covariates, there were positive correlations between LSM and endoglin (p=0.04), IL-8 (p
- Published
- 2022