1. Acute on Chronic Liver Failure From Nonalcoholic Fatty Liver Disease: A Growing and Aging Cohort With Rising Mortality
- Author
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Parth D. Shah, Vinay Sundaram, Nadim Mahmud, Arpan Patel, Rajiv Jalan, Robert J. Wong, Tiffany Wu, Ashwani K. Singal, and Mazen Noureddin
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Cirrhosis ,Adolescent ,Waiting Lists ,Population ,Young Adult ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,Risk Factors ,Internal medicine ,Nonalcoholic fatty liver disease ,medicine ,Humans ,education ,Aged ,Proportional Hazards Models ,education.field_of_study ,Hepatology ,business.industry ,Age Factors ,Acute-On-Chronic Liver Failure ,Middle Aged ,medicine.disease ,United States ,Confidence interval ,030104 developmental biology ,Cohort ,Etiology ,Population study ,Female ,030211 gastroenterology & hepatology ,business - Abstract
BACKGROUND AND AIMS We assessed the burden of nonalcoholic fatty liver disease (NAFLD)-related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. APPROACH AND RESULTS We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and categorized into NAFLD, alcohol-associated liver disease (ALD), and hepatitis C virus (HCV) infection. We used linear regression and Chow's test to determine significance in trends and evaluated waitlist outcomes using Fine and Gray's competing risks regression and Cox proportional hazards regression. Between 2005 and 2017, waitlist registrants for NAFLD-ACLF rose by 331.6% from 134 to 574 candidates (P
- Published
- 2021