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A recent study conducted at Amsterdam University Medical Center examined the immunogenicity and boostability of the hepatitis A (hepA) vaccine in adults receiving immunosuppressive therapy and adults living with HIV. The study found that the hepA vaccine was highly immunogenic in virologically suppressed individuals living with HIV and patients on immunosuppressive monotherapy. These groups had similar seroconversion rates (SCRs) to controls and adequate booster responses in case of waning immunity. However, patients using immunosuppressive combination therapy and those who did not receive the complete hepA vaccination schedule were at risk of non-response to vaccination. The study recommends post-vaccination antibody measurements for these individuals. [Extracted from the article]

A recent study conducted by researchers at the University of Michigan explores the impact of global hepatitis B vaccination on the burden of chronic hepatitis B in the United States. The study found that despite improvements in infant hepatitis B vaccination globally since 2000, work still needs to be done to achieve the World Health Organization's goal of 90% vaccination by 2030. The researchers simulated the arrival of immigrants with HBV infection to the US from 2000 to 2070 and estimated the costs and outcomes associated with different vaccination scenarios. They found that current progress in hepatitis B vaccination will lead to fewer infections, deaths, and cost savings in the US, and achieving the WHO's vaccination goals could lead to even greater savings. [Extracted from the article]

A recent study conducted by Northwestern University in Chicago, Illinois, examined the effectiveness of a bundled care initiative called the 24-hour baby bundle (24-HBB) in improving the administration of the hepatitis B virus (HBV) vaccine to newborns. The study found that the 24-HBB significantly increased the rate of HBV immunization within 24 hours of birth, from 43.83% to 66.90%. Overall, the initiative also led to an increase in hepatitis B immunization prior to discharge. The researchers suggest that similar initiatives could be implemented in newborn nurseries to prevent hepatitis B infection and promote childhood vaccination compliance. [Extracted from the article]

A study conducted at Cairo University aimed to assess the protective levels of anti-HBsAb (antibodies against the hepatitis B virus) among previously vaccinated medical residents and its relation to the duration and doses of the vaccine. The study found that the protective anti-HBsAb level is related to the number of years since vaccination and the number of vaccine doses. Only 9.4% of the residents had a negative protective titer, while 35.15% had a positive low protective titer and 55.45% had a positive high protective titer. The research suggests that the long-term protective effect of the hepatitis B vaccine and the assessment of vaccination status remain questionable. [Extracted from the article]

For more information on this research see: Impact and Cost-effectiveness of Hepatitis B Virus Prophylaxis In Pregnancy: a Dynamic Simulation Modelling Study. Keywords: London; United Kingdom; Europe; Antigens; Biomarkers; Child Immunization; DNA Viruses; Diagnostics and Screening; Digestive System Diseases and Conditions; Drugs and Therapies; Gastroenterology; Health and Medicine; Hepadnaviridae; Hepadnaviridae Infections; Hepatitis; Hepatitis B Virus; Hepatology; Immunization; Immunization and Public Health; Infectious Diseases and Conditions; Liver Diseases and Conditions; Orthohepadnavirus; Pediatric Vaccines; Pediatrics; Public Health; Risk and Prevention; Vaccination; Vaccines; Viral; Virology EN London United Kingdom Europe Antigens Biomarkers Child Immunization DNA Viruses Diagnostics and Screening Digestive System Diseases and Conditions Drugs and Therapies Gastroenterology Health and Medicine Hepadnaviridae Hepadnaviridae Infections Hepatitis Hepatitis B Virus Hepatology Immunization Immunization and Public Health Infectious Diseases and Conditions Liver Diseases and Conditions Orthohepadnavirus Pediatric Vaccines Pediatrics Public Health Risk and Prevention Vaccination Vaccines Viral Virology 1487 1487 1 09/25/23 20230925 NES 230925 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Investigators publish new report on Liver Diseases and Conditions - Hepatitis B Virus. [Extracted from the article]