1. Effect of high amylose resistant starch (HAM‐RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial
- Author
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Khosroshahi, Hamid Tayebi, Vaziri, Nosratola D, Abedi, Behzad, Asl, Bahlol Habibi, Ghojazadeh, Morteza, Jing, Wanghui, and Vatankhah, Amir Mansur
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Clinical Research ,Clinical Trials and Supportive Activities ,Complementary and Integrative Health ,Nutrition ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Amylose ,Animals ,Biomarkers ,Double-Blind Method ,Female ,Humans ,Inflammation ,Kidney Failure ,Chronic ,Male ,Middle Aged ,Oxidative Stress ,Rats ,Renal Dialysis ,Starch ,End stage renal disease ,hemodialysis ,high maize resistant starch2 ,inflammatory marker ,oxidative markers ,Urology & Nephrology ,Clinical sciences - Abstract
INTRODUCTION:Systemic inflammation and oxidative stress play a central role in the pathogenesis of cardiovascular disease and numerous other complications of CKD. Recent studies demonstrated that consumption of a diet enriched with amylose (HAM-RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. METHODS:Forty-six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM-RS2 or wheat-flour. Fasting predialysis blood samples obtained before, during and at the end of trial were processed for biomarkers of oxidative stress and inflammation. FINDINGS:There was no significant difference in baseline clinical or biochemical parameters between the two groups. Serum levels of TNF-α, IL-6, and malondialdehyde declined significantly (P
- Published
- 2018