1. Immunology 101: fundamental immunology for the practicing hematologist.
- Author
-
Carty SA
- Subjects
- Adaptive Immunity, Aged, Allergy and Immunology, Hematologic Diseases complications, Hematologic Diseases physiopathology, Hematologic Diseases therapy, Hematology, Humans, Immune System immunology, Immune System physiopathology, Immune System Diseases complications, Immune System Diseases physiopathology, Immune System Diseases therapy, Immunity, Innate, Immunotherapy methods, Male, Hematologic Diseases immunology, Immune System Diseases immunology
- Abstract
From an evolutionary perspective, the immune system developed primarily to protect the host from pathogens. In the continuous balance between killing pathogens and protecting host tissues, selective pressures have shaped the discriminatory functions of the immune system. In addition to protection against microbial pathogens, the immune system also plays a critical role in antitumor immunity. Immune dysfunction, either under- or overactivity, is found in a wide range of hematologic disorders. Here we review the fundamental features of the immune system and the key concepts critical to understanding the impact of immune dysfunction on hematologic disorders., (Copyright © 2021 by The American Society of Hematology.)
- Published
- 2021
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