1. Trisomy 12 and t(14;22)(q32;q11) in a Patient with B-cell Chronic Lymphocytic Leukemia
- Author
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Daniela Tozzuoli, Alberto Fabbri, Giuseppe Marotta, Francesco Forconi, Francesco Lauria, Simona Calabrese, Rosaria Crupi, Alessandro Gozzetti, and Mariapia Lenoci
- Subjects
Oncology ,medicine.medical_specialty ,Pathology ,Chromosomes, Human, Pair 22 ,medicine.medical_treatment ,Chronic lymphocytic leukemia ,Trisomy ,Chromosomal translocation ,Aggressive disease ,Disease-Free Survival ,Translocation, Genetic ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,B-cell chronic lymphocytic leukemia ,Chromosomes, Human, Pair 14 ,Chemotherapy ,Chromosomes, Human, Pair 12 ,business.industry ,Cytogenetics ,Hematology ,Middle Aged ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Cytogenetic Analysis ,Female ,Good prognosis ,business - Abstract
Recurrent cytogenetic abnormalities are typically found in about one third of B-cell chronic lymphocytic leukemia patients (B-CLL) by standard cytogenetic analysis and their prognostic relevance is well known. We report a case of a B-CLL patient showing both trisomy 12 and a t(14;22)(q32;q11). Trisomy 12 is often associated with aggressive disease and resistance to chemotherapy, however, our patient is in good health and currently untreated after 7 years, suggesting in this case a relatively good prognosis and a questionable role for translocations involving the 14q32 locus.
- Published
- 2004
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