1. Chemical and thyroid hormone profile of the bone marrow interstitial fluid in hematologic disorders and patients without primary hematologic disorders
- Author
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Osnat Ashur-Fabian, Eilon Krashin, Gloria Rashid, Keren Cohen, Eran Neumark, Maya Viner, and Martin Ellis
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Globulin ,Bilirubin ,03 medical and health sciences ,chemistry.chemical_compound ,Interstitial fluid ,Internal medicine ,Medicine ,Creatinine ,Triiodothyronine ,biology ,business.industry ,Thyroid ,Albumin ,Hematology ,General Medicine ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,Oncology ,chemistry ,biology.protein ,business ,Hormone - Abstract
Bone marrow interstitial fluid (BMIF) has not been well characterized. BMIF was isolated from 60 patients including plasma cell dyscrasias (PCD, n = 33), other primary hematologic disorders (OHD, n = 15), and patients with secondary or nonhemtologic disorders (NHD, n = 12) and analyzed for an array of chemical constituents. These included total cholesterol, glucose, phosphate, creatinine, urea, total protein, albumin, globulins, total bilirubin, aspartate aminotransferase, lactate dehydrogenase, sodium, osmolarity, free triiodothyronine (free T3), total triiodothyronine (total T3), and free tetraiodothyronine (free T4). Levels of BMIF components were compared between patient groups and to plasma levels. Compared with plasma, total cholesterol, total protein, total bilirubin, sodium, and calculated osmolarity were lower in BMIF in all groups (P
- Published
- 2018