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Acotoxinine (1), a new norditerpene alkaloid, was isolated from the roots of Aconitum toxicumRchb., together with the structurally related C19 diterpene alkaloids neoline (2) and aconitine (3) and C20 diterpene alkaloids songorine (4) and songoramine (5). The structures were elucidated by HR-MS and advanced NMR methods, including 1H-NMR, JMOD, 1H,1H-COSY, HSQC, and HMBC experiments. This is the first report of C20 diterpenoid alkaloids in Aconitum toxicum.

Three new, highly functionalized jatrophane diterpenes (1–3) have been isolated from the whole, dried plants of Euphorbia platyphyllos L., together with one known jatrophane polyester (4). The structures were established by UV/VIS spectroscopy, HR-ESI-MS, and advanced two-dimensional NMR, including ¹H-NMR, JMOD, ¹H,¹H-COSY, HMQC, and HMBC experiments. Stereochemical studies and conformational analyses were performed by means of NOESY experiments. Interestingly, compounds 1–4 do not represent a stereochemically uniform series because they differ in the orientations of the Me groups at C(2), C(6), and C(13). A similar observation was reported earlier for Euphorbia serrulata, whose diterpenes are related to the compounds obtained from E. platyphyllos. This chemical relationship is of taxonomic importance and supports the botanical similarity of the two species.