1. Alveolar macrophages and monocyte subpopulations during Plasmodium berghei NK65 experimental malaria-associated acute respiratory distress syndrome
- Author
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Flaviane Vieira-Santos, Ramayana Morais de Medeiros Brito, Camila de Almeida Lopes, Thais Leal-Silva, Jorge Lucas Nascimento Souza, Chiara Cássia Oliveira Amorim, Ana Cristina Loiola Ruas, Luiza de Lima Silva Padrão, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marcelo Vidigal Caliari, Remo Castro Russo, Ricardo Toshio Fujiwara, Luisa Mourão Dias Magalhães, and Lilian Lacerda Bueno
- Subjects
Alveolar macrophages ,Plasmodium berghei NK65-NY ,Acute respiratory distress syndrome ,Monocytes ,Inflammation ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Alveolar macrophages (AM) and monocytes (MO) are myeloid cells that play a substantial role in the development and establishment of the innate and adaptive immune response. These cells are crucial for host defense against various pathogens, but their role in malaria is poorly understood. Here, we characterize the dynamics of AMs and recruited leukocytes subpopulations in the airways during experimental Plasmodium berghei NK65-NY (PbNK65). We show that PbNK65 infection induces an increased pulmonary vascular permeability that provides Ly6Clow MOs, neutrophils (NEU), CD4+ and CD8+ lymphocytes in the airways. This inflammatory environment resulted in an increase in the population and alteration of the activation state of the AMs. Taken together, the data presented provide new insights into airway inflammation associated with pulmonary malaria.
- Published
- 2024
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