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4H-pyrans have been prepared through a mechanochemical multicomponent reaction (MCR) of different aldehydes, malononitrile, and various 1,3-dicarbonyl compounds, catalyzed by an amine-functionalized metal-organic framework (MOF) Cu2(NH2-BDC)2(DABCO) as a heterogeneous catalyst with good to excellent yields.

Background: Giant coronary artery aneurysms (GCAA), are rare findings often discovered incidentally in adults. GCAAs are defined by a significant enlargement of coronary arteries, posing a heightened risk of myocardial infarction and thrombosis. Case presentation: A 52-year-old male known case of ischemic heart disease (IHD), presented with chest pain and signs of anterior ST-elevation MI (STEMI). He had a history of MI six years ago and was on a medical regimen. Coronary angiography revealed a huge aneurysm (4.8∗8.2mm) in the left anterior descending artery (LAD) and ectasia in other arteries. Surgical management via coronary artery bypass graft (CABG) was pursued, successfully addressing the aneurysm. Conclusion: Recent advancements have improved our understanding and imaging capabilities for coronary artery aneurysms (CAAs). Treatment options include medical therapy, percutaneous coronary intervention, or surgery, with decisions tailored to individual cases. Standardized treatment protocols await clarification through further research, including randomized controlled trials.

Flood events in the Sefidrud River basin have historically caused significant damage to infrastructure, agriculture, and human settlements, highlighting the urgent need for improved flood prediction capabilities. Traditional hydrological models have shown limitations in capturing the complex, non-linear relationships inherent in flood dynamics. This study addresses these challenges by leveraging advanced machine learning techniques to develop more accurate and reliable flood estimation models for the region. The study applied Random Forest (RF), Bagging, SMOreg, Multilayer Perceptron (MLP), and Adaptive Neuro-Fuzzy Inference System (ANFIS) models using historical hydrological data spanning 50 years. The methods involved splitting the data into training (50–70 %) and validation sets, processed using WEKA 3.9 software. The evaluation revealed that the nonlinear ensemble RF model achieved the highest accuracy with a correlation of 0.868 and an root mean squared error (RMSE) of 0.104. Both RF and MLP significantly outperformed the linear SMOreg approach, demonstrating the suitability of modern machine learning techniques. Additionally, the ANFIS model achieved an exceptional R-squared accuracy of 0.99. The findings underscore the potential of data-driven models for accurate flood estimating, providing a valuable benchmark for algorithm selection in flood risk management.

The partial replacement of conventional natural coarse aggregate (NCA) with artificial light weight aggregate (LWA) manufactured from local clay and solid waste to develop a lightweight aggregate concrete (LWAC) for the structural use was studied in this paper. Red clay and Savar clay were used individually with solid wastes like rice husk ash (RHA) and waste glass to produce LWA. The suitability of raw materials and LWA was evaluated by investigating various properties. The mechanical, thermal and durability properties of manufactured LWAC were explored. The results of physical, chemical, thermal and geotechnical properties revealed that Red clay is better than Savar clay for the preparation of LWA. All the physical and mechanical properties of LWA prepared from Red clay are suitable for the preparation of LWAC compared to Savar clay. The test results demonstrated that the concrete manufactured by replacing 30 % of NCA with LWA produced a concrete of lightweight properties. The compressive strength of LWAC for 7 and 28 days was observed as 28 and 48 MPa, respectively. The results of modulus of elasticity, splitting tensile strength, flexural deformation, and creep test of LWAC revealed that these mechanical properties meet the requirements for the structural concrete. The RCP test proves that chlorine permeability of LWAC is comparable with NCA. It was observed that the superior performance of LWAC can be achieved only when the optimized mix designed is followed strictly. The suitability of the replacement of natural aggregate by LWA may be helpful for Bangladesh due to the scarcity of natural coarse aggregate and reusability of solid waste materials.

Background: Mesenchymal stem cells (MSCs) are commonly employed as a powerful tool for the treatment of immune-mediated problems owing to their capacity to regulate the immune system and differentiate into different tissues. Researchers use mesenchymal stem cell products given the limitations associated with the application of MSCs. Exosomes are nanometer vesicles derived from MSCs that are used in cell-free therapy. Inflammatory environmental conditions, such as stimulation of Toll-like receptor 3 (TLR-3), has the ability to adjust the immune-regulating properties and anti-inflammatory function of mesenchymal stem cells and their exosomes. Galectins and hepatocyte growth factor (HGF) are known as immunomodulatory factors in mesenchymal stem cells. This study was designed to examine the expression of galectin-1, galectin-3, galectin-9, and HGF genes in exosomes isolated from human Wharton's jelly mesenchymal stem cells (hWJ-MSCs) after stimulation with Poly (I:C) (Polyinosinic:polycytidylic acid sodium salt). Methods: To begin, the explant technique was used to extract mesenchymal stem cells from human umbilical cord Wharton's jelly. Then, the stem cells were stimulated using Poly (I:C) at three time intervals of 12, 24 and 48 h. Exosomes secreted from the supernatant of cells were extracted and exosome confirmation tests, including Scanning electron microscopy (SEM), Dynamic light scattering (DLS) and Flow cytometry were performed. Finally, the expression of galectin-1, galectin-3, galectin-9, and HGF genes in exosomes was evaluated by Real-Time PCR at three time intervals of 12, 24 and 48 h after stimulation. Results: The findings of our study indicated that following stimulation with Poly (I:C), the expression of galectin-9 and HGF (P

The use of nanotechnology can reduce the challenges facing the use of herbal compounds in the fight against infectious agents. The aim of the present research is to produce nano niosomes containing Bunium persicum essential oil with high efficiency in the temperature and acidity of the living environment of Trichomonas vaginalis parasite and to investigate its toxicity on this parasite. First, Essential oil compounds were identified using GC-Mass. Then six niosomal formulations were made using Tween 40, 60, and 80 and cholesterol by thin film method. Three formulations that have more suitable particle size, zeta potential, and essential oil release and encapsulation efficiency were selected by MTT method to investigate the toxicity on HFF (Human foreskin fibroblasts) cell line. The formulation with lower toxicity was optimized using DSPE-mPEG(2000) polymer. Encapsulation efficiency, particle size, zeta potential, release of essential oil (in temperature and acidity similar to Trichomonas vaginalis living environment), particle morphology and toxicity of optimal formulation (on HFF and Trichomonas vaginalis) were investigated. At the end, the stability of the optimized nanoparticles was studied for 120 days. 12 chemical compounds including γ-Terpinene, Cuminic aldehyde and Para-cymene were identified Bunium persicum essential oil. The optimized formulation has a particle size of 159.73 nm, a zeta potential of −25.1 mV and an encapsulation efficiency of 63.11 %, which has a slow and continuous release at the similar temperature and acidity as Trichomonas vaginalis. Niosomal nanoparticles have a spherical shape and a smooth surface and have little toxicity on the HFF cell line. Also, the toxicity of nano niosomes containing essential oil on Trichomonas vaginalis is higher than free essential oil in all concentrations. The optimized niosomal nanoparticles have good stability because their physicochemical properties have changed very little during 120 days. In conclusion optimized Niosomal formulation containing Bunium persicum essential oil compared to free essential oil can have a higher efficiency to deal with Trichomonas parasite in laboratory conditions.

In the mandibular premolar area, supernumerary teeth are a rare disorder that are rarely documented in the literature. The purpose of this study was to evaluate the post-surgical problems associated with the buccal and lingual techniques used to treat the extra teeth in this area. Using PubMed, PubMed Central, Science Direct, Cochrane, Wiley, and manual search, a thorough search was done to locate and identify cases and case series with extra teeth in the mandibular premolar region. For every study that was included, data on the surgical technique and postoperative problems were documented. Seven studies involving 90 patients were included. Supernumerary teeth in the mandibular premolar region were predominantly found in male patients (65.55 %), with most cases occurring in the right mandibular region (77.16 %). Postoperative complications after removing supernumerary teeth using buccal and lingual approaches were similar, with only one complication reported among the 90 cases reviewed. Although the findings suggest that surgical management of supernumerary teeth in the mandibular premolar region is relatively safe, caution is advised due to the limited sample size. Detailed pre-operative evaluation, a comprehensive treatment plan, and regular follow-up can minimize postoperative complications.

Large-amplitude plasma wave is known to accelerate electrons to high energies. The electron energy gain mainly depends on plasma wave amplitude. In this paper, we investigate the excitation of large-amplitude plasma waves by laser beat-wave in an inhomogeneous plasma. The idea behind this work is to employ linear and radial plasma density profiles to enhance the plasma wave amplitude. PIC simulations are used to validate the numerical solution of the nonlinear wave equation in cylindrical dimensions through the finite difference method. Furthermore, the effects of the quadratic-radial plasma density profiles and magnetic field on the plasma wave excitation are investigated. The study shows that compared to the linear density profile of plasma, the plasma wave amplitude in the case of a linear-radial density profile is far more pronounced. For the linear-radial density profile, the plasma wave amplitude remains steady over greater distances of propagation compared to the linear density profile, resulting in reduced immediate damping effects. It can also be seen that the plasma wave amplitude is higher for the quadratic-radial than for the linear-radial density profiles. The effect of a longitudinal magnetic field on plasma wave amplitude is investigated. It can be seen that the plasma wave amplitude is increased by applying a magnetic field. This study may provide a way to enhance the plasma wave field for accelerating the electrons in laser-plasma accelerators.

Intercropping is an alternative farming method that maximizes crop yield and resource usage effectiveness, especially in low-input agricultural systems. Legume-based intercropping systems can effectively boost the quality and wheat yield by promoting soil functions and microbial activities. However, changes in the types of legumes and field management can alter the response of crop functions. A three-year field study was conducted on intercropping cultivation of winter wheat variety (Butterfly and Lorien) and legume species (faba bean, incarnate clover, spring pea, winter pea) to assess grain yield and wheat quality in organic farming. Based on the results, Butterfly showed higher grain quality but lower grain yield and yield components than Lorien. Mixtures of legume crops with winter wheat did not significantly differ in wheat grain yield, but grain quality variables were significantly affected. Protein content (PC) was significantly higher in wheat and legume mixtures than in sole wheat by 4 %. PC in wheat + winter pea (Wheat + Wi) and wheat + faba bean (Wheat + Fa) were higher than wheat sown alone. Wet gluten (WG) was higher in Wheat + Wi than in sole wheat and wheat + incarnate clover mixtures (Wheat + In). The rheological parameters evaluated by the Mixolab showed greater wheat quality in Butterfly and legume mixtures. Mixed and row-row intercropping of wheat and legume species did not significantly influence rheological properties. To conclude, customizing wheat yield and grain quality under the effect of winter wheat and legume mixtures requires considering the optimal solution based on different cultivates, wheat varieties and legume species to achieve the desired response.

Because of their high protein content, easy access and low cost, pumpkin seeds are a valuable raw material for the preparation of antioxidant protein hydrolysates. Micro-coating is an effective method to protect bioactive compounds against destruction. In order to strengthen the alginate hydrogel network loaded with pumpkin seed protein hydrolysate (PSPH), CMC was added as part of its formulation in the first step, and chitosan coating was used in the second step. Then, swelling amount, release in the simulated gastrointestinal environment (SGI), antioxidant activity after SGI, Fourier transform infrared spectroscopy (FTIR), zeta potential, dynamic light scattering (DLS), polydispersity index (PDI) and scanning electron microscopy (SEM) of the samples were evaluated. The results showed that, the swelling amount of the chitosan-alginate hydrogel was lower than the chitosan-alginate-CMC sample, and with the increase in chitosan concentration, the swelling amount decreased. The release amount in the chitosan-alginate sample was higher than that in the chitosan-alginate-CMC sample, and with the increase in chitosan concentration, the release rate decreased. Also, the amount of release increased with the passage of time. The highest antioxidant activity belonged to the chitosan-alginate sample in SGI, and it increased with increasing the chitosan concentration. All findings demonstrated that the use of multi-component hybrid systems is a useful method for the protection of bioactive compounds against destruction, their antioxidant activities and their release behavior.

Shift registers are one of the main blocks in processors. In this paper, two new universal shift registers are designed based on Quantum-Dot Cellular Automata (QCA) nanotechnology. Both of the proposed level triggered and edge triggered universal shift register in QCA technology shows good performance in regards of the number of cells, occupied area, delay, and power. These designs also have reset abilities. Simulations show that the proposed 4-bit level triggered universal shift register with reset ability has 1057 QCA cells, 1.27 μm2 occupied area, and delay of about three cycles of QCA clock. In addition, the proposed rising edge triggered 4-bit universal shift register with reset ability has 1085 QCA cells, 1.27 μm2 occupied area, and delay of about three cycles of QCA clocks.

This study presents an intelligent Decision Support System (DSS) aimed at bridging the theoretical-practical gap in groundwater management. The ongoing demand for sophisticated systems capable of interpreting extensive data to inform sustainable groundwater decision-making underscores the critical nature of this research. To meet this challenge, telemetry data from six randomly selected wells were used to establish a comprehensive database of groundwater pumping parameters, including flow rate, pressure, and current intensity. Statistical analysis of these parameters led to the determination of threshold values for critical factors such as water pressure and electrical current. Additionally, a soft sensor was developed using a Random Forest (RF) machine learning algorithm, enabling real-time forecasting of key variables. This was achieved by continuously comparing live telemetry data to pump design specifications and results from regular field testing. The proposed machine learning model ensures robust empirical monitoring of well and pump health. Furthermore, expert operational knowledge from water management professionals, gathered through a Classical Delphi (CD) technique, was seamlessly integrated. This collective expertise culminated in a data-driven framework for sustainable groundwater facilities monitoring. In conclusion, this innovative DSS not only addresses the theory-application gap but also leverages the power of data analytics and expert knowledge to provide high-precision online insights, thereby optimizing groundwater management practices.

This research study was conducted to investigate the laser melting parameters of NiCrAlY-APS coating. High-temperature oxidation was investigated using yttria partially stabilized zirconia (YSZ) ceramic coating. Also, the oxidation behavior of the TBC coating was investigated and studied before to and after laser surface melting of the NiCrAlY coating. Microstructural characterization was done using a scanning electron microscope (SEM), elemental analysis by energy dispersive spectroscopy (EDS), and phase analysis by X-ray diffraction (XRD). Surface melting was then performed in the power range of 150–300 W and scanning speed of 2–6 mm s−1. Surface melting was also conducted on the coating using two strategies: single-pass and multi-pass. The obtained results showed that the average melting depth and thickness reduction were directly related to the laser power, while they had an inverse relation with the laser scanning speed. Furthermore, multi-pass surface melting parameters reduced porosity to less than 0.1 %. Roughness measurements also showed a decrease in the coating's surface hardness after surface melting, as compared to the APS coating. The structure consisted of oriented columnar dendrites after melting the laser. The adhesion strength of the TBC coating and laser surface melting coating was at 41 MPa and 53 MPa, respectively. After 200 h of oxidation in the G1504 sample, the TGO layer's growth was decreased; due to the growth of a single oxide layer, it had better oxidation resistance in comparison to the other sample.

Twenty vegetable amaranth (VA) genotypes were evaluated to assess the variability, associations, path coefficient, and principal component analysis (PCA) of morpho-chemical traits. The genotypes exhibited adequate antioxidant colorants, phytochemicals, and antiradical capacity with significant variations across genotypes. Genetic parameters revealed selection criteria for the majority of the traits for improving amaranth foliage yield (FY). Based on correlation coefficient, stem weight, stem base diameter, root weight, plant height, and shoot weight for significant development of FY of VA. Observing significant genotypic correlation with high positive direct effects on FY, the path coefficient (PC) of root weight, stem base diameter, stem weight, and shoot weight could contribute to the noteworthy development of FY of VA. The genotypes AA5, AA6, AA8, AA10, AA11, AA19, and AA20 might be selected for high FY, antioxidant colorants, and antiradical phytochemicals to utilize as colorants and antiradical rich superior high yielding cultivars. The first PC accounted for 37.8% of the variances, which implies a larger proportion of variable information explained by PC1. The features that contributed more to PC1 were FY, SW, STW, RW, and PH, whereas Chl b, total Chl, and Chl a contributed to the second PC. This suggests that there are significant genetic differences between amaranths in terms of biochemical and agro-morphological characteristics. The findings of the current work support plant breeders to investigate the genetic potential of the amaranth germplasm, notably in biochemical parameters. High colorants enrich genotypes that can be selected for extracting natural colorants to use in food processing industries.

Prostate cancer (PCa) is one of the two solid malignancies in which a higher T cell infiltration in the tumor microenvironment (TME) corresponds with a worse prognosis for the tumor. The inability of T cells to eliminate tumor cells despite an increase in their number reinforces the possibility of impaired antigen presentation. In this study, we investigated the TME at single-cell resolution to understand the molecular function and communication of dendritic cells (DCs) (as professional antigen-presenting cells). According to our data, tumor cells stimulate the migration of immature DCs to the tumor site by inducing inflammatory chemokines. Many signaling pathways such as TNF-α/NF-κB, IL2/STAT5, and E2F up-regulated after DCs enter the tumor location. In addition, some molecules such as GPR34 and SLCO2B1 decreased on the surface of DCs. The analysis of molecular and signaling alterations in DCs revealed some suppression mechanisms of tumors, such as removing mature DCs, reducing the DC's survival, inducing anergy or exhaustion in the effector T cells, and enhancing the differentiation of T cells to Th2 and Tregs. In addition, we investigated the cellular and molecular communication between DCs and macrophages in the tumor site and found three molecular pairs including CCR5/CCL5, CD52/SIGLEC10, and HLA-DPB1/TNFSF13B. These molecular pairs are involved in the migration of immature DCs to the TME and disrupt the antigen-presenting function of DCs. Furthermore, we presented new therapeutic targets by the construction of a gene co-expression network. These data increase our knowledge of the heterogeneity and the role of DCs in PCa TME.

Microbial biostimulants (MBs) promote plant growth and stress tolerance in a sustainable manner. However, precise field trials of MBs are required in natural setting with a range of crop varieties to harness the benefits of biostimulants on crop yield improvement. This study investigated the effects of two MBs, Trichoderma album and Bacillus megaterium, on an onion cultivar's growth, nutritional qualities, antioxidant properties, and yield potentials under field conditions for two successive years. Before transplantation, onion bulbs were gelatin-coated with 2.0 and 4.0 g L−1 of each of the MB. Results revealed that MBs-pretreated onion plants exhibited better growth indices, photosynthetic pigment contents, and yield-attributing features like bulb weight than control plants. Nutraceutical analysis demonstrated that T. album-pretreated (by 2.0 g L−1) onion cultivar enhanced the level of K+ (by 105.79%), Ca2+ (by 37.77%), proline (by 34.21%), and total free amino acids (by 144.58%) in bulb tissues over the control plants. Intriguingly, the pretreatment with both T. album and B. megaterium (by 2.0 g L−1) increased the levels of total soluble carbohydrates (by 19.10 and 84.02%), as well as antioxidant properties, including increased activities of superoxide dismutase (by 58.52 and 31.34%), catalase (by 164.71 and 232%), ascorbate peroxidase (by 175.35 and 212.69%), and glutathione-S-transferase (by 31.99 and 9.34%) and improved the contents of ascorbic acid (by 19.1 and 44.05%), glutathione (by 6.22 and 33.82%), and total flavonoids (by 171.98 and 56.24%, respectively) in the bulb tissues than control plants. Although both MBs promoted the growth and nutraceutical qualities of onion bulbs, T. album pretreatment showed better effects than that of B. megaterium in the field settings. Based on the morphophysiological attributes and biochemical properties, a low dose (2.0 g L−1) was more effective than a high dose (4.0 g L−1) of T. album in promoting onion growth. Overall, the current research findings imply that T. album might be a potential MB in improving growth and quality attributes, and hence the productivity of onion cultivars under field circumstances.

Pectinase is an enzyme having a broad industrial and commercial application. However, higher production costs may be the major constraint for the wide-scale application of pectinase. Therefore, researchers are trying to reduce the pectinase production cost for subsequent application in the industrial processes by using a unique substrate and optimizing the fermentation medium components and process conditions. The main purpose of the current study was to optimize medium composition for pectinase production using Aspergillus niger-ATCC 1640 in the solid-state fermentation.The Response Surface Methodology (RSM) was performed to evaluate the effects of variables, specifically the concentrations of Satkara peel, urea, (NH4)2PO4, NH4NO3, KH2PO4, ZnSO4, and MgSO4.7H2O on pectinase production in the solid substrate. Firstly, a two-factorial design, Plackett-Burman design (PBD) was applied to screen the variables that significantly influenced the pectinase production. After finding the critical variables, 15 experimental runs were carried out using a Box-Behnken design (BBD) to derive a statistical model for optimizing the concentrations of the selected variables.The PBD model revealed that Satkara peel, urea, and (NH4)2SO4 significantly affected the pectinase production. RSM results indicated that the predicted response for pectinase production was in good agreement with experimental data (R2 = 0.9836). Under the optimized condition of Satkara peel (8.4 g/L), urea (0.5 g/L), and (NH4)2SO4 (2.7 g/L), the pectinase activity was predicted to be 0.6178 μmol/mL. In the present study, the experimental pectinase production achieved 0.6045 μmol/mL. The study revealed that optimization through RSM could improve the pectinase production from Satkara peel.

Background: Inferior petrosal sinus sampling (IPSS) is known as the gold standard to distinguish whether excessive adrenocorticotropin hormone (ACTH) production origins from the pituitary gland or an ectopic source. However, due to a number of factors, the value of IPSS for adenoma lateralization may be limited. Aim of this study was to evaluate the influence of parasellar venous drainage (VD) patterns on IPSS findings in predicting lateralization of pituitary microadenomas. Methods: We retrospectively reviewed records of confirmed cases of Cushing's disease which were evaluated by IPSS prior to endoscopic tansnasal trans-sphenoidal surgery (ETSS) to assess the ability of IPSS to predict adenoma laterality. Results: Seventeen patients with pathologically confirmed Cushing's disease were retrospectively reviewed. The median age of the included patients was 37 years. Laterality of parasellar VD perfectly associated with lateralization as measured by IPSS. Symmetrical VD was associated with symmetrical ACTH gradient on IPSS. However, lateralization measured by IPSS did not show any significant correlation with lateralization detected during ETSS. Conclusion: Our study suggests that IPSS lateralization results strongly depend on parasellar VD pattern but show no significant correlation with the adenoma lateralization found during ETSS. Thus, IPSS does not appear to be an appropriate modality to predict adenoma lateralization.

Due to the instinctive temperature-dependent heat capacity of the Nano-Encapsulated Phase Change Material (NEPCM), there is a growing interest in the potential applications of such materials in heat transfer. As such, steady-state natural convection in a porous enclosure saturated with nanofluid using NEPCMs has been investigated in this study. The cavity is assumed to have constant hot and cold temperatures at the left and right vertical boundaries, respectively, and fully insulated from the bottom and top walls. Considering the Local Thermal Non-equilibrium (LTNE) approach for the porous structure, the governing equations are first non-dimensionalized and then solved by employing the finite element Galerkin method. The impact of different parameters, such as porous thermal conductivity (ks), solid-fluid interface heat transfer (10 ≤ H ≤ 105), Stefan number (0.2 ≤ Ste ≤ 1), and volume fraction of nanoparticles (0.0 ≤ φ ≤ 0.05) on the patterns of the fluid and solid isotherms, streamlines and the contours of the heat capacity ratio, fusion temperature (0.05 ≤ θf ≤ 1), local and average Nusselt numbers, and overall heat transfer ratio has been studied. It is shown that improving the porous thermal conductivity not only leads to an increase in the rate of heat transfer but also augments the fluid flow inside the cavity. For low values of the Ste, the rate of heat, transferred in the porous enclosure, is intensified. However, regardless of the amount of the Stefan number, the maximum rate of heat transfer is achievable when the non-dimensional fusion temperature is approximately 0.5. Employing NEPCMs in a highly conductive porous structure is more efficacious only when the phases are in the state of local thermal equilibrium. Nonetheless, the rate of heat transfer is higher when the Local thermal non-equilibrium is validated between the phases. Besides, for poor thermal conductivity of the porous medium like glass balls (LTE condition), adding 5% of the nano-encapsulated phase change materials to pure water can boost the rate of heat transfer up to 47% (for Ste = 0.2 and θf = 0.5). This thermal investigation of NEPCMs shows in detail how advantageous are these nanoparticles in heat transfer and opens up an avenue for further application-based studies.

Purpose: Poly (lactic-co-glycolic acid) has received much academic attention for developing nanotherapeutics and FDA has approved it for several applications. An important parameter that dictates the bioavailability and hence the biological effect of the drug is drug release from its delivering system. This study offers a comparative mathematical analysis of drug release from Poly (lactic-co-glycolic acid)–based nanoparticles to suggest a general model explaining multi-mechanistic release they provide. Methods: Eight release models, zero order, first order, Higuchi, Hixson-Crowell, the square root of mass, the three-second root of mass, Weibull and Korsmeyer-Peppas, as well as the second degree polynomial equation were applied to 60 data sets. The models analysed regarding several types of errors, regression parameters and average Akaike information criterion. Results and discussion: Most of the data sets present the highest R2, the lowest overall error and AIC for the Weibull model. Weibull model with the mean AIC = -36.37 and mean OE = 7.24 and the highest NE less than 5, 10, 15 and 20 % in most of the cases best fits the release data from various PLGA-based drug delivery systems that are studied. Weibull model seems to show enough flexibility to describe various release patterns PLGA provides.

Purpose: Ruptured blood blisters (BBA) and very small, wide necked aneurysms (VSA) remain challenging lesions to treat due to their small size, wide necks, and thin, fragile walls. In the present study, we reviewed our experience with these aneurysms treated by flow diversion. Methods: A total of 18 patients with hemorrhage due to a ruptured BBAs and VSAs, treated with flow diversion between July 2014 and March 2016 were included in this study. We analyzed clinical and radiographic outcomes. Results: A total of 12 (66.7%) VSAs and 6 (33.3%) BBAs were treated with flow diversion. Fifteen (83.3%) and three (16.7%) aneurysms were located on the internal carotid artery and the basilar artery, respectively. On admission, a GCS score of 15 and WFNS grade 1 were found in 14 (77.7%) patients, 3 patients had an admission GCS of 13 and WFNS grade 2, one had an admission GCS of 8 and WFNS of 4. Fisher CT grades 2, 3, and 4 were observed in 11 (61.1%), 1 (5.6%), and 6 (33.3%) patients, respectively. Flow diversion was performed on average 5.6 days after onset of hemorrhage. 6 months post-intervention angiography showed complete obliteration of the aneurysms in all patients. Conclusion: Our findings indicate that flow diversion in the acute and subacute phase of hemorrhage is a reliable treatment for reducing complications in patients with BBAs and VSAs. In patients with poor clinical presentation it might be reasonable to delay treatment until the first signs of recovery become apparent.

Essential oils (EOs) are known for uses in various fields such as perfume, cosmetic, pharmaceutical and food industries. Agricultural wastes are among the resources of EOs that produced and disposed of in large quantities annually. Hence, in this study, for the first time, EOs available from pistachio fruit [fruit pistachio shells (FPS) and fruit pistachio cluster (FPC)] were used to the extraction of EOs. The Clevenger device and distilled water were used to extract EOs. The amount of total phenolic compounds (TPC) by Folin-ciocalteu reagent and the radical scavenging ability (RSA%) of FPS and FPC extracted by the soaking method were also measured. The RSA% of EOs and extracts in the presence of DPPH free radicals was evaluated by the IC50 index. Chemical composition of EOs detected by mass spectrometric gas chromatography. Notwithstanding amounts of extraction efficiency by water in the soaking method from FPS and FPC was 4.6% and 3.2% respectively, EOs extraction efficiency from FPC and FPS was 2.10% and 0.13% respectively. TPC in FPS and FPC was 958.38 and 796.25 mgGA/100g dry material respectively. The amount of IC50 of FPS was 3760.69 ppm and near to RSA% of BHT (2354.36 ppm). Statistical difference was observed between the RSA of EOs and positive control antioxidant (P < 0.05). The RSA of antioxidant extracts and TPC showed positively correlated. The major compounds identified in FPS were the D-limonene, α-thujene and terpinolene, abundance respectively, and the major components of FPC were α-thujene and α-pinene, abundance respectively.