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3 results on '"Zak Loring"'

1. Catheter ablation of atrial fibrillation in patients with diabetes mellitus

Author

Allen Wang, MD, Tracy Truong, MB, Eric Black-Maier, MD, Cynthia Green, PhD, Kristen B. Campbell, PharmD, Adam S. Barnett, MD, Janice Febre, BSN, RN, Zak Loring, MD, MHS, Sana M. Al-Khatib, MD, MHS, FHRS, Brett D. Atwater, MD, James P. Daubert, MD, FHRS, Camille Frazier-Mills, MD, MHS, Donald D. Hegland, MD, Kevin P. Jackson, MD, Larry R. Jackson, MD, Jason I. Koontz, MD, PhD, Robert K. Lewis, MD, PhD, Sean D. Pokorney, MD, MBA, Albert Y. Sun, MD, Kevin L. Thomas, MD, Tristam D. Bahnson, MD, FHRS, and Jonathan P. Piccini, MD, MHS, FHRS

Subjects
Atrial fibrillation, Catheter ablation, Diabetes mellitus, Glycemic control, Outcomes, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. Objective: The purpose of this study was to compare AF ablation outcomes in patients with and those without DM. Methods: We performed a retrospective analysis of 351 consecutive patients who underwent first-time AF ablation. Clinical outcomes included freedom from recurrent atrial arrhythmia, symptom burden (Mayo AF Symptom Inventory score), cardiovascular and all-cause hospitalizations, and periprocedural complications. Results: Patients with DM (n = 65) were older, had a higher body mass index, more persistent AF, more hypertension, and larger left atrial diameter (P

Published
2020
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2. Diagnosis-to-ablation time predicts recurrent atrial fibrillation and rehospitalization following catheter ablation

Author

Daniel B. Mark, Zak Loring, Derek V. Exner, Derek S. Chew, Jennifer Grant, Jonathan P. Piccini, Douglas L. Packer, Peter A. Noseworthy, Kelley A. Jones, and Eric Black-Maier

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Recurrent atrial fibrillation, Hazard ratio, Catheter ablation, Atrial fibrillation, Ablation, medicine.disease, Heart failure, Internal medicine, Cohort, medicine, Cardiology, Sinus rhythm, business
Abstract

Background Wait times for catheter ablation in patients with symptomatic atrial fibrillation (AF) may influence clinical outcomes. Objective This study examined the relationship between the duration from AF diagnosis to ablation, or diagnosis-to-ablation time (DAT), on the clinical response to catheter ablation in a large nationwide cohort of patients. Methods We identified patients with new atrial fibrillation (AF) who underwent catheter ablation between January 2014 and December 2017 using the IBM MarketScan databases. Cox proportional hazard models were used to estimate the strength of the association between DAT and the outcomes of AF recurrence and hospitalization at one year post-ablation. Results Among 11,143 AF patients who underwent ablation, the median age was 59 years, 31% were female and the median CHA2DS2-VASc score was 2. Median DAT was 5.5 (2.6, 13.1) months. At 1-year post-ablation, 10.0% (N=1,116) developed recurrent AF. For each year increase in DAT, the risk of AF recurrence increased by 20% after adjustment for baseline comorbidities and medications (hazard ratio (HR) 1.20, 95% CI 1.11-1.30). A longer DAT was associated with an increased risk of hospitalization (HR 1.08 per DAT year, 95% CI 1.02-1.15). DAT was a stronger predictor of AF recurrence post-ablation than traditional clinical risk factors, including age, prior heart failure, or renal failure. Conclusions Increasing duration between AF diagnosis and catheter ablation is associated with higher AF recurrence rates and all-cause hospitalization. Our findings are consistent with a growing body of evidence supporting the benefits of prioritizing early restoration of sinus rhythm.

Published
2022

3. Catheter ablation of atrial fibrillation in patients with diabetes mellitus

Author

James P. Daubert, Albert Y. Sun, Janice Febre, Jonathan P. Piccini, Kevin L. Thomas, Adam S. Barnett, Donald D. Hegland, Eric Black-Maier, Tracy Truong, Tristam D. Bahnson, Robert K. Lewis, Kevin P. Jackson, Cynthia L. Green, Sana M. Al-Khatib, Zak Loring, Brett D. Atwater, Camille Frazier-Mills, Kristen Bova Campbell, Jason I. Koontz, Larry R. Jackson, Allen Wang, and Sean D. Pokorney

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Poor glycemic control, Atrial fibrillation, Catheter ablation, Outcomes, Ablation, medicine.disease, Clinical, Text mining, Diabetes mellitus, Glycemic control, RC666-701, Internal medicine, medicine, Cardiology, Diseases of the circulatory (Cardiovascular) system, In patient, Risk factor, business, Body mass index
Abstract

Background: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. Objective: The purpose of this study was to compare AF ablation outcomes in patients with and those without DM. Methods: We performed a retrospective analysis of 351 consecutive patients who underwent first-time AF ablation. Clinical outcomes included freedom from recurrent atrial arrhythmia, symptom burden (Mayo AF Symptom Inventory score), cardiovascular and all-cause hospitalizations, and periprocedural complications. Results: Patients with DM (n = 65) were older, had a higher body mass index, more persistent AF, more hypertension, and larger left atrial diameter (P

Published
2021

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