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1. PO-04-169 DELAYED EFFECT OF CATHETER ABLATION FOR INTRAMURAL OUTFLOW TRACT VENTRICULAR ARRHYTHMIAS

Author

Guan-Yi Li, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Jo-Nan Liao, TA-CHUAN TUAN, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Cheng-I Wu, Shin-Huei Liu, Ming-Jen Kuo, Shang-Ju Wu, Yushan Huang, Jose Antonio Bautista, Yoon Kee Siow, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

5. PO-02-159 ABLATION OF ATRIAL FIBRILLATION AND DEMENTIA RISK REDUCTION DURING LONG-TERM FOLLOW-UP: A NATIONWIDE POPULATION-BASED STUDY

Author

Guan-Yi Li, Yun-Yu Chen, Yenn-Jiang Lin, Kuo-Liong Chien, Yu-Cheng Hsieh, Fa-Po Chung, Li-Wei Lo, Shih-Lin Chang, Yu-Feng Hu, TA-CHUAN TUAN, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Cheng-I Wu, Shin-Huei Liu, Ming-Jen Kuo, Shang-Ju Wu, Yushan Huang, Jose Antonio Bautista, Yoon Kee Siow, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

6. PO-05-073 CHARACTERISTICS OF BIPOLAR AND UNIPOLAR ELECTROGRAMS AT SUCCESSFUL ABLATION TARGETS FOR VENTRICULAR ARRHYTHMIA ORIGINATING FROM THE VICINITY OF LEFT VENTRICULAR SUMMIT

Author

Guan-Yi Li, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, TA-CHUAN TUAN, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Cheng-I Wu, Shin-Huei Liu, Ming-Jen Kuo, Shang-Ju Wu, Yushan Huang, Jose Antonio Bautista, Yoon Kee Siow, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

7. PO-02-199 A NOVEL FINDING: SERUM MICRORNA-122 CORRELATES WITH LEFT ATRIAL SUBSTRATE IN PATIENTS WITH ATRIAL FIBRILLATION

Author

Guan-Yi Li, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, T.A.-C.H.U.A.N. TUAN, Tze-Fan Chao, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Cheng-I Wu, Shin-Huei Liu, Ming-Jen Kuo, Shang-Ju Wu, Yushan Huang, Jose Antonio Bautista, Yoon Kee Siow, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

8. PO-05-120 CLINICAL SIGNIFICANCE OF POST-ABLATION PREMATURE VENTRICULAR COMPLEXES BURDEN IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY UNDERWENT ABLATION FOR VENTRICULAR TACHYCARDIA

Author

Yushan Huang, Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, TA-CHUAN TUAN, Ling Kuo, Cheng-I Wu, Jo-Nan Liao, Ting-Yung Chang, Chih-Min Liu, Shin-Huei Liu, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

11. AB-452666-3 CATHETER ABLATION IN ASIAN PATIENTS WITH ATRIAL FIBRILLATION AND HYPERTROPHIC CARDIOMYOPATHY: ELECTROPHYSIOLOGICAL CHARACTERISTICS OF RECURRENCE AND LONG-TERM CLINICAL OUTCOMES

Author

Chih-Hsien Lin, Chin-Yu Lin, Fa-Po Chung, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Jo-Nan Liao, Ting-Yung Chang, TA-CHUAN TUAN, Ling Kuo, Cheng-I Wu, Chih-Min Liu, Shin-Huei Liu, Guan-Yi Li, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

13. PO-01-228 CLINICAL SIGNIFICANCE OF STRUCTURAL REMODELING CONCERNING SUBSTRATE CHARACTERISTICS AND ABLATION OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION AND MITRAL REGURGITATION

Author

Jose Antonio Bautista, Chi-Ting Lu, Chin-Yu Lin, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, TA-CHUAN TUAN, Tze-Fan Chao, Jo-Nan Liao, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Cheng-I Wu, Ming-Jen Kuo, Guan-Yi Li, Yu-Shan Huang, Shang-Ju Wu, Yoon Kee Siow, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

15. PO-04-208 CLINICAL APPLICATION OF ARTIFICIAL INTELLIGENCE IN PREDICTION OF RECURRENCE IN ATRIAL FIBRILLATION PATIENTS WITH CATHETER ABLATION

Author

Chih-Min Liu, Shih-Lin Chang, Wei Shiang Chen, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Tze-Fan Chao, TA-CHUAN TUAN, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Cheng-I Wu, Ling Kuo, Mei-Han Wu, Chun-Ku Chen, Ying-Yueh Chang, Yang-Che Shiu, Henry Horng-Shing Lu, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

16. Renal denervation prevents myocardial structural remodeling and arrhythmogenicity in a chronic kidney disease rabbit model

Author

Wen Han Cheng, Wei Lun Lin, Yu Hui Chou, Tseng Ying Tsai, Shih Ann Chen, Shinya Yamada, Li Wei Lo, and Shin Huei Liu

Subjects
medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, 030204 cardiovascular system & hematology, Kidney, urologic and male genital diseases, 03 medical and health sciences, Renal Artery, 0302 clinical medicine, Physiology (medical), medicine.artery, Internal medicine, Neuromodulation, Autonomic Denervation, medicine, Animals, 030212 general & internal medicine, Renal Insufficiency, Chronic, Renal artery, Denervation, Ventricular Remodeling, business.industry, Arrhythmias, Cardiac, Atrial Remodeling, medicine.disease, Fibrosis, female genital diseases and pregnancy complications, Nephrectomy, Treatment Outcome, medicine.anatomical_structure, Models, Animal, Catecholamine, Cardiology, Immunohistochemistry, Myocardial fibrosis, Rabbits, Cardiomyopathies, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, business, Kidney disease, medicine.drug
Abstract

The electrophysiological (EP) effects and safety of renal artery denervation (RDN) in chronic kidney disease (CKD) are unclear.The purpose of this study was to investigate the arrhythmogenicity of RDN in a rabbit model of CKD.Eighteen New Zealand white rabbits were randomized to control (n = 6), CKD (n = 6), and CKD-RDN (n = 6) groups. A 5/6 nephrectomy was selected for the CKD model. RDN was applied in the CKD-RDN group. All rabbits underwent cardiac EP studies for evaluation. Immunohistochemistry, myocardial fibrosis, and renal catecholamine levels were evaluated.The CKD group (34.8% ± 9.2%) had a significantly higher ventricular arrhythmia (VA) inducibility than the control (8.6% ± 3.8%; P.01) and CKD-RDN (19.5% ± 6.3%; P = .01) groups. In the CKD-RDN group, ventricular fibrosis was significantly decreased compared to the CKD group (7.4% ± 2.0 % vs 10.4% ± 3.7%; P = .02). Sympathetic innervation in the CKD group was significantly increased compared to the control and CKD-RDN groups [left ventricle: 4.1 ± 1.8 vs 0.8 ± 0.5 (10Neuromodulation by RDN demonstrated protective effects with less structural and electrical remodeling, leading to attenuated VAs. In a rabbit model of CKD, RDN plays a therapeutic role by lowering the risk of VA caused by autonomic dysfunction.

Published
2021

20. PO-04-183 ARTIFICIAL INTELLIGENCE-ENABLED MODEL FOR EARLY DETECTION OF ATRIAL FIBRILLATION DURING SINUS RHYTHM AND MORTALITY RISK STRATIFICATION

Author

Yu-Feng Hu, Chih-Min Liu, Wei-Wen Chen, I-Chien Wu, Pei-Fen Chen, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Fa-Po Chung, Tze-Fan Chao, TA-CHUAN TUAN, Jo-Nan Liao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Cheng-I Wu, Shin-Hui Liu, Henry Horng-Shing Lu, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

23. PO-02-101 CATHETER ABLATION IN ASIAN PATIENTS WITH ATRIAL FIBRILLATION AND DILATED CARDIOMYOPATHY: ELECTROPHYSIOLOGICAL CHARACTERISTICS OF RECURRENCE AND LONG-TERM CLINICAL OUTCOMES

Author

Yoon Kee Siow, Chin-Yu Lin, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, TA-CHUAN TUAN, Tze-Fan Chao, Jo-Nan Liao, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Cheng-I Wu, Ming-Jen Kuo, Guan-Yi Li, Yushan Huang, Shang-Ju Wu, Jose Antonio Bautista, Ngoc Nguyen Dinh Son, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2023

32. PO-709-06 THREE-DIMENSIONAL MAPPING SYSTEM FACILITATED SUPERIOR APPROACH FOR RADIOFREQUENCY ABLATION OF TACHYARRHYTHMIA IN PATIENTS WITHOUT INFERIOR VENA CAVA ACCESS

Author

Chu-Yu Hsu, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Chin-Yu Lin, Ting-Yung Chang, Chieh-Mao Chuang, Ming-Jen Kuo, Wei Tso Chen, Chheng Chhay, Pei Heng Kao, Ahliah Esmilla Ibrahim, Wei-Hsiang Lin, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2022

34. PO-681-04 THE CLINICAL VALUE AND LONG-TERM OUTCOME OF CATHETER ABLATION BY USING HIGH DENSITY VECTOR FIELD MAPPING FOR PERSISTENT ATRIAL FIBRILLATION

Author

Ming-Jen Kuo, Yenn-Jiang Lin, Chin-Yu Lin, Men-Tzung Lo, Chia-Hsin Chiang, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Da Chyuan Duan, Tze-Fan Chao, Jo-Nan Liao, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Wei Tso Chen, Pei Heng Kao, Guan-Yi Li, Chih-Hsien Lin, and Shih-Ann Chen

Subjects
Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2022

37. Seasonal variation in the risk of ischemic stroke in patients with atrial fibrillation: A nationwide cohort study

Author

Shih Ann Chen, Tzeng Ji Chen, Fa Po Chung, Yenn Jiang Lin, Jo Nan Liao, Tze Fan Chao, Yu Feng Hu, Gregory Y.H. Lip, Li Wei Lo, Chung-Lieh Hung, Su Jung Chen, Chia Jen Liu, Ta Chuan Tuan, and Shih Lin Chang

Subjects
Male, medicine.medical_specialty, Taiwan, 030204 cardiovascular system & hematology, Rate ratio, Risk Assessment, Brain Ischemia, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Physiology (medical), Internal medicine, Atrial Fibrillation, Humans, Medicine, 030212 general & internal medicine, Stroke, Aged, business.industry, Incidence, Incidence (epidemiology), Age Factors, Atrial fibrillation, medicine.disease, Confidence interval, Survival Rate, Population Surveillance, Cardiology, Female, Seasons, Cardiology and Cardiovascular Medicine, business, Risk assessment, Follow-Up Studies, Cohort study
Abstract

Several cardiovascular diseases exhibit seasonal variations, but data about cold temperature and risk of ischemic stroke in patients with atrial fibrillation (AF) are limited.The purpose of this study was to investigate the risk of ischemic stroke in different seasons, testing the hypothesis that the cold weather season would increase the risk of stroke in AF.This study used the National Health Insurance Research Database in Taiwan. From 2000 to 2012, a total of 289,559 AF patients were enrolled, and 34,991 experienced ischemic stroke after mean follow-up of 3 years. The relationship between risk of ischemic stroke and temperatures was analyzed.The highest incidence of ischemic stroke was observed in winter, which was the coldest season, with an incidence rate of 0.33 per 100 person-months. Compared with the summer period, the risk of ischemic stroke increased by 10% in spring (incidence rate ratio [IRR] 1.10; 95% confidence interval [CI] 1.07-1.13) and by 19% in winter (IRR 1.19; 95% CI 1.15-1.22) but did not differ significantly between summer and autumn (IRR 1.00; 95% CI 0.97-1.03). Compared with the days with an average temperature of 30°C, the risk of ischemic stroke for days with an average temperature20°C significantly increased. Lower 7-, 10-, or 14-day average temperatures were significantly associated with an increased risk of ischemic stroke in the case-crossover analysis.In this nationwide study, a seasonal variation of incidence of ischemic stroke in AF patients was observed, with an increased risk of stroke on days with an average temperature20°C. AF-related stroke may be influenced by environmental interactions.

Published
2018

38. B-PO02-042 ENHANCED DETECTION OF CARDIAC ARRHYTHMIAS UTILIZING 14-DAY CONTINUOUS ECG PATCH MONITORING

Author

Yu Feng Hu, Yung-Hsin Yeh, Lung-Sheng Wu, Yenn Jiang Lin, Chih-Min Liu, Ming-Shien Wen, Po-Cheng Chang, Shih Ann Chen, Kuo-Chun Hung Chung-Chuan Chou, Jo-Nan Liao, Fa Po Chung, Li-Wei Lo, Yi-Hsin Chan, and Shih Lin Chang

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2021

39. B-PO02-092 NOVEL PREDICTOR OF PAROXYSMAL ATRIAL FIBRILLATION RECURRENCES AFTER ABLATION: THE ROLE OF LEFT ATRIAL DECELERATION ZONE

Author

Jo-Nan Liao, Chin-Yu Lin, Yenn Jiang Lin, Ting-Yung Chang, An Khanh Nu Ton, Yu Feng Hu, Shih Ann Chen, Li-Wei Lo, Fa Po Chung, Ta-Chuan Tuan, Shih Lin Chang, Tze-Fan Chao, and Pei Heng Kao

Subjects
medicine.medical_specialty, Left atrial, business.industry, Paroxysmal atrial fibrillation, Physiology (medical), Internal medicine, medicine.medical_treatment, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Ablation
Published
2021

40. B-PO05-096 USING REENTRANT MODE IN A REAL-TIME DYNAMIC SOFTWARE (LIVEVIEW) IN IDENTIFYING PV GAPS AND CONDUCTION BLOCKS DURING PV ISOLATION

Author

Ta-Chuan Tuan, Chin-Yu Lin, Ting-Yung Chang, An Khanh Nu Ton, Pei Heng Kao, Tze-Fan Chao, Shih Ann Chen, Linda Lin Chu-Yu Hsu, Chih-Min Liu, Shin-Huei Liu, Ming-Jen Kuo, Yenn Jiang Lin, Wei Tso Chen, Jo-Nan Liao, Fa Po Chung, Chheng Chhay, Shih Lin Chang, Ahmed Moustafa Elimam, Ling Kuo, Yu Feng Hu, Wen Han Cheng, and Li-Wei Lo

Subjects
Reentrancy, business.industry, Physiology (medical), Mode (statistics), Electronic engineering, Medicine, Isolation (database systems), Cardiology and Cardiovascular Medicine, business, Thermal conduction, Dynamic software
Published
2021

41. B-PO03-030 EFFICACY OF ESTROGEN SUPPLEMENT ON VENTRICULAR SUBSTRATE IN A RABBIT MODEL OF MENOPAUSE

Author

Shih Lin Chang, Wen Han Cheng, Yenn Jiang Lin, Shih Ann Chen, Tseng-Ying Tsai, Fa Po Chung, Yu Feng Hu, Shin-Huei Liu, Li-Wei Lo, Yu-Hui Chou, and Wei Lun Lin

Subjects
medicine.medical_specialty, business.industry, medicine.drug_class, Substrate (chemistry), medicine.disease, Menopause, Endocrinology, Estrogen, Physiology (medical), Internal medicine, Rabbit model, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2021

42. B-PO04-096 FACTORS PREDICTING THE PROGRESSION FROM PAROXYSMAL TO PERSISTENT ATRIAL FIBRILLATION DESPITE AN INDEX CATHETER ABLATION PROCEDURE

Author

Chin-Yu Lin, Shih Lin Chang, Tze-Fan Chao, Fa Po Chung, Chheng Chhay, An Khanh Nu Ton, Yu Feng Hu, Dony Yugo, Pei Heng Kao, Ta-Chuan Tuan, Ahmed Moustafa Elimam, Jo-Nan Liao, Li-Wei Lo, Wen Han Cheng, Wei Tso Chen, Chih-Min Liu, Ling Kuo, Shih Ann Chen, Linda Lin, Yenn Jiang Lin, and Shin-Huei Liu

Subjects
medicine.medical_specialty, Index (economics), business.industry, Physiology (medical), Internal medicine, medicine.medical_treatment, Persistent atrial fibrillation, medicine, Cardiology, Catheter ablation, Cardiology and Cardiovascular Medicine, business
Published
2021

43. B-PO02-114 LONG-TERM OUTCOME OF PATIENTS WITH LONGSTANDING PERSISTENT ATRIAL FIBRILLATION WITH CARTOFINDER - A PROPENSITY SCORE MATCHING STUDY

Author

Fa Po Chung, Ting-Yung Chang, Shih Lin Chang, Yenn Jiang Lin, Yu Feng Hu, Shih Ann Chen, and Li-Wei Lo

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, Propensity score matching, Cardiology, medicine, Longstanding persistent atrial fibrillation, Cardiology and Cardiovascular Medicine, business, Outcome (game theory), Term (time)
Published
2021

44. B-PO04-071 ELECTROPHYSIOLOGICALLY-GUIDED PULMONARY VEIN ISOLATION AND SUBSTRATE IN PATIENTS WITH PERSISTENT ATRIAL FIBRILLATION USING PRISM INDEX: A MULTICENTER STUDY

Author

Chin-Yu Lin, Chia-Hsin Chiang, Shih Lin Chang, Ling Kuo, Men Tzung Lo, Ting-Yung Chang, Akira Maesato, Shin-Huei Liu, Chih-Min Liu, Sugako Ishigaki, Satoshi Higa, Yu Feng Hu, Fa Po Chung, Wen Han Cheng, Ming-Jen Kuo, Yenn Jiang Lin, Li-Wei Lo, and Shih Ann Chen

Subjects
medicine.medical_specialty, Multicenter study, business.industry, Physiology (medical), Internal medicine, Persistent atrial fibrillation, medicine, Cardiology, In patient, Prism, Cardiology and Cardiovascular Medicine, business, Pulmonary vein
Published
2021

45. B-PO04-176 THE ARTIFICIAL INTELLIGENCE-ENABLED ENDOCARDIAL SIGNAL PREDICTION OF TERMINATION SITE DURING CATHETER ABLATION OF PERSISTENT ATRIAL FIBRILLATION

Author

Chin-Yu Lin, Shih Ann Chen, Ling Kuo, Fa Po Chung, Cheng-I Wu, Tze-Fan Chao, Yu Feng Hu, Li-Wei Lo, Yenn Jiang Lin, Chia Hsin Chiang, Ta-Chuan Tuan, Men Tzung Lo, Chih Min Liu, Jo-Nan Liao, Ting-Yung Chang, and Shih Lin Chang

Subjects
medicine.medical_specialty, Signal prediction, business.industry, Physiology (medical), Internal medicine, medicine.medical_treatment, Persistent atrial fibrillation, medicine, Cardiology, Catheter ablation, Cardiology and Cardiovascular Medicine, business
Published
2021

46. B-PO03-079 DECREASED RISK OF ATRIAL FIBRILLATION AFTER CATHETER ABLATION OF CAVOTRICUSPID ISTHMUS ABLATION FOR PATIENTS WITH ATRIAL FLUTTER WITHOUT HISTORY OF ATRIAL FIBRILLATION

Author

Shin-Huei Liu, Tze-Fan Chao, Chin-Yu Lin, Yun-Yu Chen, Li-Wei Lo, Ting-Yung Chang, Yenn Jiang Lin, Dony Yugo, Fa Po Chung, Yu Feng Hu, Chih-Min Liu, Shih Ann Chen, Wen Han Cheng, Ling Kuo, Shih Lin Chang, Jo-Nan Liao, and Ming-Jen Kuo

Subjects
medicine.medical_specialty, Cavotricuspid isthmus, business.industry, medicine.medical_treatment, Atrial fibrillation, Catheter ablation, medicine.disease, Ablation, Physiology (medical), Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business, Atrial flutter
Published
2021

48. Outcomes of catheter ablation of ventricular arrhythmia originating from the left ventricular summit: A multicenter study

Author

Li Wei Lo, Shih Ann Chen, Yasuhiro Shirai, Pasquale Santangeli, Hung Yu Chang, Yu Feng Hu, Yenn Jiang Lin, Fa Po Chung, Piotr Futyma, Shih Lin Chang, Francis E. Marchlinski, and Chin Yu Lin

Subjects
Male, medicine.medical_specialty, Percutaneous, medicine.medical_treatment, Heart Ventricles, Catheter ablation, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Recurrence, Physiology (medical), Aortic sinus, Internal medicine, medicine, Humans, 030212 general & internal medicine, Endocardium, Retrospective Studies, business.industry, Incidence (epidemiology), Middle Aged, Ablation, medicine.anatomical_structure, Treatment Outcome, Multicenter study, Baseline characteristics, Cardiology, Catheter Ablation, Tachycardia, Ventricular, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Background Catheter ablation has been considered an effective strategy for the treatment of ventricular arrhythmias (VAs) originating from the left ventricular summit (LVS). However, the inherent complexity of the anatomy of the LVS may result in failed ablation or recurrence of VA. Objective The purpose of this multicenter study was investigate the procedural outcomes of ablation of LVS VA. Methods A total of 238 patients (54.6% men; mean age 53.2 ± 15.0 years) undergoing catheter ablation of LVS VA were included. Baseline characteristics, procedural parameters, and clinical outcomes were analyzed. Results Acute procedural success was achieved in 199 patients (83.6%). Initial epicardial ablation via the coronary venous system (93.8% [91/97]) or percutaneous transpericardial approach (6.2% [6/97]) achieved successful ablation in 40 of 97 patients (41.2%), and VA was eliminated by initial approaches from the aortic sinus of Valsalva or subvalvular endocardium in 68 of 139 patients (48.9%; P = .29). Multisite ablations were performed in the process of acute VA elimination in 105 patients (51.8%), and 7 complications occurred. During median follow-up of 26 (1–87) months, 82.2% of patients with acute success were free from VA recurrences, and the overall long-term success rate was 68.1%. Multisite ablation was the only independent predictor of VA recurrences. Conclusion Acute elimination of VA originating from the LVS could be achieved in 83.6% of patients, with 82.2% having no VA recurrences. Despite acute elimination of VA with multisite ablation, the incidence of VA recurrence still was high.

Published
2019

49. The presence of ectopic atrial rhythm predicts adverse cardiovascular outcomes in a large hospital-based population

Author

Po Tseng Lee, Fa Po Chung, Jo-Nan Liao, Ting-Yung Chang, Yenn Jiang Lin, Li-Wei Lo, Ta-Chuan Tuan, Pei-Fen Chen, Tze-Fan Chao, Shih Lin Chang, Jennifer Jeanne B. Vicera, Shih Ann Chen, Isaiah C. Lugtu, Ankit Jain, Yu Feng Hu, Sung-Hao Huang, Chih Min Liu, I-Chien Wu, Chin-Yu Lin, and Ting Chun Huang

Subjects
Adult, Male, medicine.medical_specialty, Population, Taiwan, Ectopic Atrial Rhythm, Electrocardiography, Heart Rate, Physiology (medical), Internal medicine, otorhinolaryngologic diseases, medicine, Heart rate variability, Humans, Sinus rhythm, education, Propensity Score, Aged, Retrospective Studies, Sinoatrial Node, Aged, 80 and over, education.field_of_study, business.industry, Sinoatrial node, Incidence, Hazard ratio, Middle Aged, Confidence interval, Hospitals, Survival Rate, medicine.anatomical_structure, Propensity score matching, Cardiology, Female, Atrial Premature Complexes, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Whether ectopic atrial rhythm (EAR) is a high-risk cardiovascular phenotype (eg, the manifestation of a diseased sinoatrial node) or just a benign accelerated ectopic pacemaker remains unclear.We aimed to analyze the cardiovascular outcomes and underlying mechanisms in patients with EAR.From a 12-lead electrocardiogram hospital-based electrocardiogram database, a total of 2896 adults with EAR were propensity score matched at 1:5 with 14,480 patients with sinus rhythm (SR). Patients were retrospectively followed up for cardiovascular mortality (the primary outcome) and permanent pacemaker implantation (the secondary outcome). Heart rate variability was analyzed to compare autonomic function between patients with EAR and those with SR.The prevalence of EAR was 1.13%, which increased with age. Compared with the matched patients, those with EAR had a higher risk of cardiovascular mortality (adjusted hazard ratio 1.93; 95% confidence interval 1.52-2.44; P.0001) and permanent pacemaker implantation (adjusted hazard ratio 5.94; 95% confidence interval 3.89-9.09; P.0001) according to the Cox proportional hazards regression model. The risk of cardiovascular mortality was similar across the subgroups on the basis of age, sex, hypertension, type 2 diabetes mellitus, congestive heart failure, myocardial infarction, stroke, and chronic kidney diseases. In patients with EAR, the low frequency/high frequency and standard deviation of the mean normal-to-normal intervals/root mean square of successive RR interval differences ratios for heart rate variability were both lower than those in patients with SR. This implied autonomic imbalance in patients with EAR.Patients with EAR have a higher risk of cardiovascular mortality and permanent pacemaker implantation, which was associated with autonomic imbalance.

Published
2019

50. B-PO03-031 RENAL SYMPATHETIC DENERVATION PREVENTS THE LIFE-THREATENING ARRHYTHMIAS THROUGH RESTORATIONS OF CALCIUM DYNAMICS IN SLEEP DISORDERED BREATHING

Author

Pin-Yi Lin, Shih Ann Chen, Wei Lun Lin, Tzu-Yen Peng, Yu-Hui Chou, Wen Han Cheng, Shin-Huei Liu, and Li-Wei Lo

Subjects
medicine.medical_specialty, business.industry, Renal sympathetic denervation, Calcium dynamics, Physiology (medical), Internal medicine, Sleep disordered breathing, Cardiology, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2021

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