1. Association between genetic loci linked to HDL-C levels and Indian patients with CAD: a pilot study
- Author
-
T.F. Ashavaid, Ashley Stanley, C.K. Ponde, and R.M. Rajani
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,business.industry ,CAD ,medicine.disease ,Bioinformatics ,Preliminary analysis ,Coronary artery disease ,03 medical and health sciences ,030104 developmental biology ,Internal medicine ,medicine ,lipids (amino acids, peptides, and proteins) ,Significant risk ,Cardiology and Cardiovascular Medicine ,business ,Genotyping ,LILRA3 ,Lipoprotein cholesterol ,Original Research - Abstract
To examine the association between loci linked to high-density lipoprotein cholesterol (HDL-C) levels and coronary artery disease (CAD).A pilot study consisting of age-matched and gender-matched angiographically confirmed CAD cases (n=150) and non-CAD controls (n=150) was performed to test an association. Illumina's Human Cardio-Metabo BeadChip containing 3112 variants associated with HDL-C levels was used for genotyping.A preliminary analysis identified 36 variants from 16 genes that were statistically significant (p0.05) between cases and controls. However, none of the variants remained statistically significant after correction for multiple testing. Besides, variants rs11039159 (None of the HDL-C associated loci included in this study were found to be a significant risk factor for CAD. However, the study could replicate the findings of four variants influencing HDL-C levels.
- Published
- 2016