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Although epicardial adipose tissue (EAT) and abdominal visceral adipose tissue (VAT) can contribute to left ventricular diastolic dysfunction (LVDD), the impact of these distribution has not been fully understood. A total of 235 patients who underwent cardiac computed tomography angiography and Doppler echocardiography was included in this study. We evaluated the association of indexed EAT volume and VAT area with septal and lateral early diastolic mitral annular velocity (e′). The VAT area index was significantly associated with septal and lateral e′ velocity after adjusted for conventional cardiovascular risk factors and obstructive coronary artery disease (β-estimate; − 0.015 and − 0.019, both p = 0.01). The natural logarithmic EAT volume index (ln EAT volume index) also showed a significant association with septal and lateral e′ (β-estimate; − 1.72 and − 0.99, both p < 0.01). The significant association of ln EAT volume index with septal and lateral e′ was observed even after adjusting for VAT area index (β-estimate; − 0.79 and − 1.52, both p < 0.03). In the subgroup analysis, there were significant association of ln EAT volume index with both septal and lateral e′ in the lower VAT group (β-estimate; − 1.40 and − 1.53, both p < 0.03) and with lateral e′ in the higher VAT group (β-estimate − 1.64, p = 0.006). In contrast, ln EAT volume index was not associated with septal e′ in the higher VAT group (p = 0.98). EAT accumulation was significantly associated with LVDD independently of obstructive coronary artery disease and abdominal VAT. The impact of EAT on LVDD may vary depending on the amount of abdominal VAT. [ABSTRACT FROM AUTHOR]

Atrial fibrillation (AF) is a common disease that changes cardiac morphology, especially in the left atrium (LA). It is now known that certain categories of functional mitral regurgitation (MR) are associated with AF; however, the influence of AF on right cardiac morphology is not fully understood. Our aim in this study was to investigate the association between AF and right cardiac morphology. This was a retrospective cohort study of 86 patients with persistent AF without other cardiac disease who underwent catheter ablation (CA). Seventy-one patients had sustained sinus rhythm (SR) (SR Group) and 15 patients had sustained AF (AF Group) during the study period. We compared the changes in the right cardiac dimensions and tricuspid regurgitation (TR) between the groups 12 months after CA. Patients' baseline echocardiographic assessments revealed that the LA volume index was significantly smaller in the SR group than in the AF group (46.8 ± 11.9 ml/m2 vs 59.3 ± 12.8 ml/m2, respectively; p < 0.01). Comparing baseline data with the 12-month follow-up data, in the SR group, right atrial area (RAA, cm2), tricuspid annular diameter (mm), and tricuspid regurgitant jet area (cm2) were significantly decreased compared with the AF group (19.5 ± 4.5–15.5 ± 3.6 vs 20.7 ± 3.6–19.7 ± 2.3; 30.5 ± 4.9–26.4 ± 3.9 vs 28.7 ± 4.0–28.8 ± 3.1; and 1.4 [interquartile range (IQR) 0.7–2.6]–0.6 [IQR 0.2–1.2] vs 1.2 [IQR 1.1–1.5]–0.9 [IQR 0.4–1.3], respectively). On multivariate analysis, change in RAA correlated with the reduction in tricuspid regurgitant jet area (R = 0.51, p < 0.001). In conclusion, successful CA for persistent AF led to right heart reverse remodeling, and our findings suggested that persistent AF was associated with RAA dilatation and TR. [ABSTRACT FROM AUTHOR]