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1. Predictors of outcome in patients with moderate mixed aortic valve disease.

Author

Patel, Kush P., McKenna, Michael, Thornton, George D., Vandermolen, Sebastian, Abdulelah, Zaid Ali, Awad, Wael, Baumbach, Andreas, Mathur, Anthony, Treibel, Thomas A., Lloyd, Guy, Mullen, Michael J., and Bhattacharyya, Sanjeev

Subjects
HEART failure, AORTIC valve diseases, HEART valve prosthesis implantation, AORTIC valve insufficiency
Published
2024
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2. Predictors of outcome in patients with moderate mixed aortic valve disease

Author

Patel, Kush P, primary, McKenna, Michael, additional, Thornton, George D, additional, Vandermolen, Sebastian, additional, Abdulelah, Zaid Ali, additional, Awad, Wael, additional, Baumbach, Andreas, additional, Mathur, Anthony, additional, Treibel, Thomas A, additional, Lloyd, Guy, additional, Mullen, Michael J, additional, and Bhattacharyya, Sanjeev, additional

Published
2023
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3. Sex differences in left ventricular remodelling, myocardial fibrosis and mortality after aortic valve replacement

Author

Singh, Anvesha, Musa, Tarique Al, Treibel, Thomas A, Vassiliou, Vassiliou S, Captur, Gabriella, Chin, Calvin, Dobson, Laura E, Pica, Silvia, Loudon, Margaret, Malley, Tamir, Rigolli, Marzia, Foley, James Robert John, Bijsterveld, Petra, Law, Graham R, Dweck, Marc Richard, Myerson, Saul G, Prasad, Sanjay K, Moon, James C, Greenwood, John P, and McCann, Gerry P

Subjects
Aged, 80 and over, Heart Valve Prosthesis Implantation, Male, Sex Characteristics, Ventricular Remodeling, Myocardium, aortic stenosis, Aortic Valve Stenosis, Kaplan-Meier Estimate, Middle Aged, Prognosis, Fibrosis, United Kingdom, AVR, Echocardiography, Valvular Heart Disease, Aortic Valve, Humans, Female, Longitudinal Studies, Postoperative Period, CMR, Aged
Abstract

Objectives : To investigate sex-differences in left ventricular remodeling and outcome in patients undergoing surgical or transcatheter aortic valve replacement (SAVR/TAVR). Methods : In this multicentre, observational, outcome study with imaging core lab analysis, patients with severe aortic stenosis (AS) listed for intervention at one of six UK centres were prospectively recruited and underwent cardiovascular magnetic resonance imaging (CMR). The primary endpoint was all-cause mortality and secondary endpoint was cardiovascular mortality. Results : 674 patients (425 male, 249 female, age 7514 years) were included: 399 SAVR, 275 TAVR. Females were older, had higher surgical risk scores and underwent TAVR more frequently (53% vs. 33.6%, p

Published
2019
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4. United Kingdom standards for non-invasive cardiac imaging: recommendations from the Imaging Council of the British Cardiovascular Society.

Author

Treibel, Thomas A., Kelion, Andrew, Ingram, Thomas E., Archbold, R. Andrew, Myerson, Saul G., Menezes, Leon J., Morgan-Hughes, Gareth J., Schofield, Rebecca, Keenan, Niall G., Clarke, Sarah C., Keys, Alan, Keogh, Bruce, Masani, Navroz, Ray, Simon, Westwood, Mark, Pearce, Keith, Colebourn, Claire L., Bull, Russell K., Greenwood, John Pierre, and Roditi, Giles H.

Subjects
CHEST pain, CARDIAC imaging, CLINICAL governance, DIAGNOSTIC ultrasonic imaging personnel, MAGNETIC resonance imaging, CARDIAC magnetic resonance imaging, MEDICAL personnel, MEDICAL sciences
Abstract

Heart and circulatory diseases affect more than seven million people in the UK. Non-invasive cardiac imaging is a critical element of contemporary cardiology practice. Progressive improvements in technology over the last 20 years have increased diagnostic accuracy in all modalities and led to the incorporation of non-invasive imaging into many standard cardiac clinical care pathways. Cardiac imaging tests are requested by a variety of healthcare practitioners and performed in a range of settings from the most advanced hospitals to local health centres. Imaging is used to detect the presence and consequences of cardiovascular disease, as well as to monitor the response to therapies. The previous UK national imaging strategy statement which brought together all of the non-invasive imaging modalities was published in 2010. The purpose of this document is to collate contemporary standards developed by the modality-specific professional organisations which make up the British Cardiovascular Society Imaging Council, bringing together common and essential recommendations. The development process has been inclusive and iterative. Imaging societies (representing both cardiology and radiology) reviewed and agreed on the initial structure. The final document therefore represents a position, which has been generated inclusively, presents rigorous standards, is applicable to clinical practice and deliverable. This document will be of value to a variety of healthcare professionals including imaging departments, the National Health Service or other organisations, regulatory bodies, commissioners and other purchasers of services, and service users, i.e., patients, and their relatives. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis

Author

Patel, Kush P, primary, Scully, Paul Richard, additional, Nitsche, Christian, additional, Kammerlander, Andreas A, additional, Joy, George, additional, Thornton, George, additional, Hughes, Rebecca, additional, Williams, Suzanne, additional, Tillin, Therese, additional, Captur, Gabriella, additional, Chacko, Liza, additional, Kelion, Andrew, additional, Sabharwal, Nikant, additional, Newton, James D, additional, Kennon, Simon, additional, Ozkor, Mick, additional, Mullen, Michael, additional, Hawkins, Philip N, additional, Gillmore, Julian D, additional, Menezes, Leon, additional, Pugliese, Francesca, additional, Hughes, Alun D, additional, Fontana, Marianna, additional, Lloyd, Guy, additional, Treibel, Thomas A, additional, Mascherbauer, Julia, additional, and Moon, James C, additional

Published
2021
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6. Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis

Author

Patel, Kush P, Scully, Paul Richard, Nitsche, Christian, Kammerlander, Andreas A, Joy, George, Thornton, George, Hughes, Rebecca, Williams, Suzanne, Tillin, Therese, Captur, Gabriella, Chacko, Liza, Kelion, Andrew, Sabharwal, Nikant, Newton, James D, Kennon, Simon, Ozkor, Mick, Mullen, Michael, Hawkins, Philip N, Gillmore, Julian D, Menezes, Leon, Pugliese, Francesca, Hughes, Alun D, Fontana, Marianna, Lloyd, Guy, Treibel, Thomas A, Mascherbauer, Julia, and Moon, James C

Abstract

ObjectiveThe coexistence of wild-type transthyretin cardiac amyloidosis (ATTR) is common in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI). However, the impact of ATTR and AS on the resultant AS-ATTR is unclear and poses diagnostic and management challenges. We therefore used a multicohort approach to evaluate myocardial structure, function, stress and damage by assessing age-related, afterload-related and amyloid-related remodelling on the resultant AS-ATTR phenotype.MethodsWe compared four samples (n=583): 359 patients with AS, 107 with ATTR (97% Perugini grade 2), 36 with AS-ATTR (92% Perugini grade 2) and 81 age-matched and ethnicity-matched controls. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy was used to diagnose amyloidosis (Perugini grade 1 was excluded). The primary end-point was NT-pro Brain Natriuretic Peptide (BNP) and secondary end-points related to myocardial structure, function and damage.ResultsCompared with older age controls, the three disease cohorts had greater cardiac remodelling, worse function and elevated NT-proBNP/high-sensitivity Troponin-T (hsTnT). NT-proBNP was higher in AS-ATTR (2844 (1745, 4635) ng/dL) compared with AS (1294 (1077, 1554)ng/dL; p=0.002) and not significantly different to ATTR (3272 (2552, 4197) ng/dL; p=0.63). Diastology, hsTnT and prevalence of carpal tunnel syndrome were statistically similar between AS-ATTR and ATTR and higher than AS. The left ventricular mass indexed in AS-ATTR was lower than ATTR (139 (112, 167) vs 180 (167, 194) g; p=0.013) and non-significantly different to AS (120 (109, 130) g; p=0.179).ConclusionsThe AS-ATTR phenotype likely reflects an early stage of amyloid infiltration, but the combined insult resembles ATTR. Even after treatment of AS, ATTR-specific therapy is therefore likely to be beneficial.

Published
2022
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7. 024 Spectrum and significance of CMR findings in cardiac transthyretin amyloidosis

Author

Martinez-Naharro, Ana, primary, Treibel, Thomas A, additional, Abdel-Gadir, Amna, additional, Bulluck, Heerajnarain, additional, Zumbo, Giulia, additional, Knight, Daniel S, additional, Kotecha, Tushar, additional, Francis, Rohin, additional, Hutt, David, additional, Rezk, Tamer, additional, Rosmini, Stefania, additional, Quarta, Cristina, additional, Whelan, Carol J, additional, Kellman, Peter, additional, Gillmore, Julian D, additional, Moon, James C, additional, Hawkins, Philip N, additional, and Fontana, Marianna, additional

Published
2017
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8. 008 Demonstration of cardiac AL amyloidosis regression after succesful chemotherapy. a CMR study

Author

Martinez-Naharro, Ana, primary, Abdel-Gadir, Amna, additional, Treibel, Thomas A, additional, Zumbo, Giulia, additional, Knight, Daniel S, additional, Rosmini, Stefania, additional, Lane, RN Thirusha, additional, Mahmood, Shameem, additional, Sachchithanantham, Sajitha, additional, Whelan, Carol J, additional, Lachmann, Helen J, additional, Wechalekar, Ashutosh D, additional, Kellman, Peter, additional, Gillmore, Julian D, additional, Moon, James C, additional, Hawkins, Philip N, additional, and Fontana, Marianna, additional

Published
2017
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9. 001 Multiparametric mapping to understand pathophysiology in cardiac amyloidosis

Author

Kotecha, Tushar, primary, Martinez-Naharro, Ana, additional, Treibel, Thomas A, additional, Francis, Rohin, additional, Nordin, Sabrina, additional, Abdel-Gadir, Amna, additional, Knight, Daniel S, additional, Zumbo, Giulia, additional, Rosmini, Stefania, additional, Maestrini, Viviana, additional, Bulluck, Heerajnarain, additional, Rakhit, Roby, additional, Wechalekar, Ashutosh D, additional, Kellman, Peter, additional, Gillmore, Julian D, additional, Moon, James C, additional, Hawkins, Philip N, additional, and Fontana, Marianna, additional

Published
2017
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10. 028 Routine identification of hypoperfusion in cardiac amyloidosis by myocardial blood flow mapping

Author

Martinez-Naharro, Ana, primary, Knight, Daniel S, additional, Kotecha, Tushar, additional, Francis, Rohin, additional, Zumbo, Giulia, additional, Treibel, Thomas A, additional, Nickander, Jannike, additional, Themudo, Raquel, additional, Gillmore, Julian D, additional, Ugander, Martin, additional, Moon, James C, additional, Xue, Hui, additional, Kellman, Peter, additional, Hawkins, Philip N, additional, and Fontana, Marianna, additional

Published
2017
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