1. Early Outcomes After Mitral Valve Repair versus Replacement in the Elderly: A Propensity Matched Analysis
- Author
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Liam Ring, Hannah Povey, Yasir Abu-Omar, Shakil Farid, Narain Moorjani, Joanne Frances Irons, Ayyaz Ali, Andrew Ladwiniec, Jules Hernández-Sánchez, and E. Caruana
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Population ,Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Degenerative disease ,Mitral valve ,Humans ,Medicine ,Cardiac Surgical Procedures ,Propensity Score ,education ,Aged ,Retrospective Studies ,Aged, 80 and over ,Heart Valve Prosthesis Implantation ,Mitral valve repair ,education.field_of_study ,business.industry ,Mitral valve replacement ,Mitral Valve Insufficiency ,medicine.disease ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,030228 respiratory system ,Propensity score matching ,Mitral Valve ,Female ,Cardiology and Cardiovascular Medicine ,business ,Mitral valve surgery - Abstract
Background To compare early outcomes of mitral valve repair versus replacement in elderly patients with degenerative mitral valve disease. Methods A retrospective review of prospectively collected clinical data of patients over 75 years of age, who underwent mitral valve surgery for degenerative disease, between 2010 and 2013, was carried out. Those undergoing mitral valve repair and replacement were propensity matched to adjust for baseline clinical differences. Results A total 260 patients were identified: mitral valve repair was undertaken in 145 and replacement in 115 patients. After propensity matching, 78 patients were included in each group. In the entire, unmatched population, in-hospital mortality was significantly higher in those undergoing replacement compared with those undergoing repair (9.6% vs 1.4%, p=0.003). In-hospital death occurred in six (7.7%) of the propensity matched replacement group and none in the repair group (p=0.012). Amongst the propensity matched groups, probability of survival at 1, 2 and 3 years were 0.94, 0.90 and 0.86 respectively for the repair group and 0.85, 0.77 and 0.69 for the replacement group: the HR for death between replacement and repair is 2.5 (1.2-5.4), p=0.012. Conclusions Within the limitations imposed by retrospective analyses, our study demonstrates that, in elderly patients with degenerative disease of the mitral valve, repair is associated with improved short-term and mid-term outcomes compared with mitral valve replacement.
- Published
- 2019
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