1. Freedom SOLO-Associated Thrombocytopaenia is Valve-Dependent and Not Due to In Vitro Pseudothrombocytopaenia
- Author
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Janne Cadamuro, Olaf Stanger, Sarah Henning Longnus, Richard Krausler, Michael Grabherr, Andreas Meinitzer, and Brigitta Gahl
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Aortic valve ,medicine.medical_specialty ,medicine.drug_class ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Aortic valve replacement ,Internal medicine ,Animals ,Humans ,Medicine ,Platelet ,In patient ,610 Medicine & health ,Aged ,Aged, 80 and over ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,Platelet Count ,business.industry ,Anticoagulant ,Mean age ,medicine.disease ,Thrombocytopenia ,Surgery ,Cardiac surgery ,medicine.anatomical_structure ,030228 respiratory system ,Aortic Valve ,Heart Valve Prosthesis ,Cardiology ,Cattle ,Female ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
BACKGROUND Use of the Freedom SOLO (FS) stentless aortic bioprosthesis is limited by a unique and as yet unexplained severe decrease in postoperative platelet count in the absence of FS-related excess bleeding or thromboembolism. We investigated whether anticoagulant-associated pseudothrombocytopaenia could explain this complication. METHODS Thirty consecutive patients (mean age 75.4±7.7 years, 11 [36.7%] female) underwent elective aortic valve replacement (AVR) with either the stented bovine Mitroflow (MF, n=18) or the stentless bovine FS (n=12) aortic valve bioprostheses. Serial platelet counts were performed simultaneously with sampling tubes containing tripotassium (K3-)-EDTA, trisodium (Na3)-citrate, or novel alternative magnesium sulfate (MgSO4, ThromboExact™)-based anticoagulant, respectively. RESULTS Postoperative platelet counts decreased compared with preoperative values in all patients (p
- Published
- 2017
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