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Many users of bilateral cochlear implants (BiCIs) localize sound sources less accurately than do people with normal hearing. This may be partly due to using two independently functioning CIs with fixed compression, which distorts and/or reduces interaural level differences (ILDs). Here, we investigate the potential benefits of using binaurally coupled, dynamic compression inspired by the medial olivocochlear reflex; an approach termed "the MOC strategy" (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). Twelve BiCI users were asked to localize wideband (125–6000 Hz) noise tokens in a virtual horizontal plane. Stimuli were processed through a standard (STD) sound processing strategy (i.e., involving two independently functioning sound processors with fixed compression) and three different implementations of the MOC strategy: one with fast (MOC1) and two with slower contralateral control of compression (MOC2 and MOC3). The MOC1 and MOC2 strategies had effectively greater inhibition in the higher than in the lower frequency channels, while the MOC3 strategy had slightly greater inhibition in the lower than in the higher frequency channels. Localization was most accurate with the MOC1 strategy, presumably because it provided the largest and less ambiguous ILDs. The angle error improved slightly from 25.3° with the STD strategy to 22.7° with the MOC1 strategy. The improvement in localization ability over the STD strategy disappeared when the contralateral control of compression was made slower, presumably because stimuli were too short (200 ms) for the slower contralateral inhibition to enhance ILDs. Results suggest that some MOC implementations hold promise for improving not only speech-in-noise intelligibility, as shown elsewhere, but also sound source lateralization. • Sound lateralization for bilateral cochlear-implant users was tested using virtual acoustics. • Binaural sound coding inspired by the medial olivocochlear reflex can enhance inter-aural level differences. • The use of binaurally coupled compression can improve sound lateralization. [ABSTRACT FROM AUTHOR]

Auditory research has a rich history of combining experimental evidence with computational simulations of auditory processing in order to deepen our theoretical understanding of how sound is processed in the ears and in the brain. Despite significant progress in the amount of detail and breadth covered by auditory models, for many components of the auditory pathway there are still different model approaches that are often not equivalent but rather in conflict with each other. Similarly, some experimental studies yield conflicting results which has led to controversies. This can be best resolved by a systematic comparison of multiple experimental data sets and model approaches. Binaural processing is a prominent example of how the development of quantitative theories can advance our understanding of the phenomena, but there remain several unresolved questions for which competing model approaches exist. This article discusses a number of current unresolved or disputed issues in binaural modelling, as well as some of the significant challenges in comparing binaural models with each other and with the experimental data. We introduce an auditory model framework, which we believe can become a useful infrastructure for resolving some of the current controversies. It operates models over the same paradigms that are used experimentally. The core of the proposed framework is an interface that connects three components irrespective of their underlying programming language: The experiment software, an auditory pathway model, and task-dependent decision stages called artificial observers that provide the same output format as the test subject. [ABSTRACT FROM AUTHOR]

We have recently proposed a binaural cochlear implant (CI) sound processing strategy inspired by the contralateral medial olivocochlear reflex (the MOC strategy) and shown that it improves intelligibility in steady-state noise (Lopez-Poveda et al., 2016, Ear Hear 37:e138-e148). The aim here was to evaluate possible speech-reception benefits of the MOC strategy for speech maskers, a more natural type of interferer. Speech reception thresholds (SRTs) were measured in six bilateral and two single-sided deaf CI users with the MOC strategy and with a standard (STD) strategy. SRTs were measured in unilateral and bilateral listening conditions, and for target and masker stimuli located at azimuthal angles of (0°, 0°), (−15°, +15°), and (−90°, +90°). Mean SRTs were 2–5 dB better with the MOC than with the STD strategy for spatially separated target and masker sources. For bilateral CI users, the MOC strategy (1) facilitated the intelligibility of speech in competition with spatially separated speech maskers in both unilateral and bilateral listening conditions; and (2) led to an overall improvement in spatial release from masking in the two listening conditions. Insofar as speech is a more natural type of interferer than steady-state noise, the present results suggest that the MOC strategy holds potential for promising outcomes for CI users. [ABSTRACT FROM AUTHOR]

Abstract: In an effort to examine the rules by which information of bilaterally applied bone-conducted signals arising from interaural time differences (ITD) and interaural intensity differences (IID) is combined, data were measured for continuous 500 Hz narrow band noise at 65–70 dB HL in 11 patients with bilateral congenital aural atresia. Time–intensity trading functions were obtained by shifting the sound image towards one side using ITD, and shifting back to a centered sound image by varying the IID in the same ear (auditory midline task). ITD values were varied from −600 to +600 μs at 200 μs steps, where negative values indicate delays to the right ear. The results indicate that time–intensity trading is present in patients with bilateral aural atresia. The gross response properties of time–intensity trading in response to bone-conducted signals were comparable in patients with bilateral aural atresia and normal-hearing subjects, though there was a larger inter-subject variability and higher discrimination thresholds across IIDs in the atresia group. These results suggest that the mature auditory brainstem has a potential to employ binaural cues later in life, although to a restricted degree. A binaural fitting of a bone-conducted hearing aid might optimize binaural hearing and improve sound lateralization, and we recommend now systematically bilateral fitting in aural atresia patients. [Copyright &y& Elsevier]

l Binaural processing of envelope (ENV) and temporal fine structure (TFS) information was examined by frequency-following responses (FFRs) in rat ICC. l Binaural FFR ENV received a predominant contribution from contralateral inputs while inhibited by ipsilateral inputs, showing a binaural inhibition property. l Binaural FFR TFS was excited by the inputs from both sides, showing a binaural summation property. l Results suggested distinct binaural integration mechanisms for ENV and TFS information. Complex broadband sounds are decomposed by peripheral auditory filters into a series of relatively narrowband signals, each with a slowly varying envelope (ENV) and a rapidly fluctuating temporal fine structure (TFS). ENV and TFS information at the bilateral ears contribute differentially to auditory perception. However, whether the difference could attribute to mechanisms of binaural integration remains an open question. As a potential neural correlate, subsets of neurons in the central nucleus of the inferior colliculus (ICC) are known to integrate binaural information with binaural inhibition or binaural summation. Therefore, we recorded the frequency-following responses (FFRs) to the ENV and TFS components of narrowband noises in the ICC of anesthetized rats and examined changes in FFR amplitude and stimulus-response coherence under various sound-delivery settings. We showed that binaural FFR ENV was predominantly elicited by contralateral inputs and inhibited by ipsilateral inputs, exhibiting a "binaural-inhibition" like property. On the other hand, binaural FFR TFS received a balanced contribution from both sides, echoing the "binaural-summation" mechanism. What is more, binaural FFR ENV was significantly correlated with contralateral-evoked but not ipsilateral-evoked FFR ENV , while binaural FFR TFS correlated with both contralateral- and ipsilateral-evoked FFR TFS. Overall, these results suggest distinct binaural processing of ENV and TFS information at the midbrain level. [ABSTRACT FROM AUTHOR]

Within the cochlea, broadband sounds like speech and music are filtered into a series of narrowband signals, each with a relatively slowly varying envelope (ENV) imposed on a rapidly oscillating carrier (the temporal fine structure, TFS). Information about ENV is conveyed by the timing and short-term rate of action potentials in the auditory nerve while information about TFS is conveyed by synchronization of action potentials to a specific phase of the waveform in the cochlea (phase locking). This paper describes the effects of age and hearing loss on the binaural processing of ENV and TFS information, i.e. on the processing of differences in ENV and TFS at the two ears. The binaural processing of TFS information is adversely affected by both hearing loss and increasing age. The binaural processing of ENV information deteriorates somewhat with increasing age but is only slightly affected by hearing loss. The reduced TFS processing abilities found for older/hearing-impaired subjects may partially account for the difficulties that such subjects experience in complex listening situations when the target speech and interfering sounds come from different directions in space. • The binaural processing of envelope (ENV) and temporal fine structure (TFS) is reviewed. • Hearing loss and greater age adversely affect the processing of interaural time differences in TFS. • Hearing loss and greater age only slightly affect the processing of interaural time differences in ENV. • Hearing loss and greater age are associated with reduced masking level differences. • Hearing loss and greater age are associated with reduced spatial release from masking. [ABSTRACT FROM AUTHOR]