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Background: Evaluation of the association between treatment satisfaction and health‐related quality of life (HRQoL) may enable health‐care providers to understand the issues that influence quality of life and to recognize the aspects of hypertension treatment that need improvement to enhance the long‐term treatment outcomes. Objective: The aim of this study was to determine the relationship between HRQoL and treatment satisfaction in a sample of Palestinian hypertensive patients. Methods: A cross‐sectional study was conducted, adopting the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4) for the assessment of treatment satisfaction and using the European Quality of Life scale (EQ‐5D‐5L) for the assessment of HRQoL. Descriptive and comparative statistics were used to describe socio‐demographic and disease‐related characteristics of the patients. All analyses were performed using SPSS v 15.0. Results: Four hundred and ten hypertensive patients were enrolled in the study. This study findings indicate a positive correlation between all satisfaction domains and HRQoL. Significant differences were observed between this study variables (P < 0.001). After adjustment for covariates using multiple linear regression, an increase of one point in the global satisfaction scale was associated with a 0.16 increase in EQ‐5D index scores (r = 0.16; P < 0.001). Conclusions: Patients with reportedly higher satisfaction scores have reported relatively higher EQ‐5D‐5L index values. These study findings could be helpful in clinical practice, mainly in the early treatment of hypertensive patients, at a point where improving treatment satisfaction and HRQoL is still possible. [ABSTRACT FROM AUTHOR]