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A recent study conducted at the National University of San Luis in Argentina focused on mapping the hydrophobic floor at the active site of DNA gyrase B (GyrB) from E. coli. The researchers synthesized three new compounds with pendant groups targeting the hydrophobic floor and evaluated their inhibitory activities on DNA gyrase. One of the compounds exhibited strong inhibitory activity against E. coli DNA gyrase. The study provides insights into the mechanism of action of these new ligands at the molecular level and suggests that future ligand optimization strategies should focus on strengthening interactions at the hydrophobic floor while preserving the binding mode of the main scaffold. [Extracted from the article]

A study conducted at Adama Science and Technology University in Ethiopia focused on the synthesis and characterization of two pyrazoline derivatives. These derivatives were tested for their antibacterial activity against various bacteria, including Gram-negative and Gram-positive strains. The results showed that both derivatives exhibited good activity against the tested bacterial strains. Additionally, the derivatives were evaluated for their antioxidant activity and their binding pattern with human myeloperoxidase and S. aureus gyrase. The study concluded that the synthesized compounds showed promising results in terms of antibacterial activity and binding scores. [Extracted from the article]

Vietnam, Asia, Medicinal Chemistry, Health and Medicine, Enzymes and Coenzymes, Gyrase, Hanoi Keywords: Hanoi; Vietnam; Asia; Medicinal Chemistry; Health and Medicine; Enzymes and Coenzymes; Gyrase EN Hanoi Vietnam Asia Medicinal Chemistry Health and Medicine Enzymes and Coenzymes Gyrase 4228 4228 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Health and Medicine - Medicinal Chemistry have been published. [Extracted from the article]