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A recent study conducted at the University of Santiago de Compostela in Lugo, Spain, focused on the aggregation properties of Amyloid-(3 1-40 (A(340) peptides using fluorescence correlation spectroscopy. The research revealed that A(340 undergoes a two-step cooperative aggregation process, forming metastable oligomers and stable oligomers before progressing to larger aggregates. Interestingly, A(340 showed a lower propensity for aggregation compared to A(342, and early oligomers of A(340 were found to be reversible upon dilution. These findings contribute to a better understanding of the role of A(340 in Alzheimer's disease and may inform future therapeutic strategies targeting amyloid aggregation. [Extracted from the article]

A recent study conducted by researchers at the University of Santiago in Spain focused on comparing the potency and binding of Pacific and Caribbean ciguatoxins, which are known to cause ciguatera poisoning. The research challenges the assumption that Caribbean ciguatoxins are ten times less potent than Pacific ciguatoxins, presenting evidence of similar cytotoxicity and distinct binding within sodium channels. The study utilized in silico simulations, functional cell studies, and molecular dynamics simulations to provide a detailed understanding of the toxins' effects on an atomic scale. This peer-reviewed research sheds light on the biological effects of marine toxins and their impact on human health. [Extracted from the article]

Keywords: Lugo; Spain; Europe; Health and Medicine EN Lugo Spain Europe Health and Medicine 3033 3033 1 09/25/23 20230929 NES 230929 2023 SEP 29 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Health and Medicine. Keywords for this news article include: Lugo, Spain, Europe, Health and Medicine, University Hospital Lucus Augusti. [Extracted from the article]