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A recent study conducted at the First Hospital of China Medical University aimed to explore the transferability of reference intervals (RIs) for lymphocyte subsets across different flow cytometry platforms. The study compared four different flow cytometer systems and found that the RIs of lymphocyte subsets could be transferred between these systems, except for natural killer (NK) cells. The results suggest that transferring RIs between flow cytometry systems is a feasible and convenient approach for clinical laboratories. The study provides valuable insights for researchers and practitioners in the field of clinical chemistry and laboratory medicine. [Extracted from the article]

A recent study conducted at the Medical University of Warsaw in Poland explored the potential of beta-escin combined with chokeberry fruit extract as an anti-inflammatory intervention for tobacco smokers. Nine smoking volunteers received the combination daily for 7 days, and the effects on neutrophil number, IL-6 and IL-8 concentration, antioxidant capacity, and alehyde dehydrogenase (ALDH) activity were evaluated. The study found that the treatment led to a decrease in neutrophil concentration and an increase in macrophage concentration in smokers' sputum, as well as a rise in antioxidant capacity. The researchers concluded that beta-escin and chokeberry fruit extract may effectively lower inflammation associated with tobacco smoking and contribute to reducing toxicity in the airways. [Extracted from the article]

A recent study conducted by the Department of Otolaryngology in Boston, Massachusetts has found a new method for removing celloidin from archival human brain and temporal bone sections. Celloidin is a substance that hinders the use of these sections for modern molecular-pathological research. The researchers used polyethylene glycols (PEGs) combined with an improved section mounting technique to effectively dissolve celloidin without damaging the tissue. This breakthrough allows for the use of decades-old archival sections in immunohistochemical and other molecular biological techniques, enhancing safety and workflow efficiency. The study was supported by the NIH National Institute on Deafness & Other Communication Disorders. [Extracted from the article]

This article discusses a study on the effects of hypochlorous acid (HOCl) on DNA and mutagenesis in lung epithelial cells. Neutrophilic inflammation, which occurs in the airways during irritation, leads to the release of myeloperoxidase (MPO) and neutrophil extracellular traps (NETs) containing DNA. The study found that HOCl produced by MPO can damage the cell genome, leading to mutagenic end-oxidation products. However, the researchers discovered that trapping HOCl-induced DNA-centered radicals with the nitrone spin trap DMPO can reduce the formation of these mutagenic products and prevent gene mutation. This research suggests potential therapeutic avenues for reducing genotoxic damage in sites of neutrophilic inflammation. [Extracted from the article]

This article discusses a study on the development of monoclonal antibodies against two strains of norovirus, GII.4 and GII.17. The researchers immunized mice with virus-like capsid particles and used hybridoma technology to generate hybridoma cells that produce antibodies against these strains. The study found that IgM antibodies require multivalent binding for efficient binding to norovirus, while IgG antibodies achieve high affinity even with monovalent binding. The researchers suggest that the high density of antigen protrusion domain in the norovirus capsid facilitates efficient binding of IgM antibodies. This preprint has not yet undergone peer review. [Extracted from the article]

A recent study conducted at the Autonomous University in Tepic, Mexico, explored the effects of the organophosphate pesticide diazoxon on leukocytes, a type of blood cell. The researchers found that diazoxon altered key molecular parameters related to cell signaling, specifically affecting molecules involved in leukocyte activation, differentiation, and survival. The study concluded that diazoxon deregulates cell signaling by altering IP3, cAMP, and JAK/STAT. This research provides valuable insights into the potential immunotoxic effects of diazoxon and its impact on the immune response. [Extracted from the article]

A recent study conducted at the University of Health Sciences Turkiye explored the relationship between ultrasonographically assessed biceps brachii muscle mass and complete blood cell count and blood chemistry variables in older palliative care patients. The study included 214 patients, and the results showed that biceps brachii muscle thickness and cross-sectional area were positively correlated with serum albumin and creatinine levels. Serum albumin levels were found to be independently associated with biceps brachii muscle mass. The researchers suggest that further studies are needed to generalize these findings. [Extracted from the article]

A newly developed electrochemical sensor has been created to detect intact bacteria, which is crucial for diagnosing diseases and ensuring food safety. Unlike previous methods, this sensor can distinguish between active bacteria and their decay products. The sensor works by using an artificial glycocalyx, a sugar molecule structure found on specific body cells, as "bait" to capture targeted bacteria. The researchers have successfully detected harmful microorganisms, such as Escherichia coli, even in small quantities, and plan to further test the method's effectiveness in practical applications. [Extracted from the article]

More about Ameya Mashruwala, Ph.D. Ameya Mashruwala, Ph.D., originally from India, is a bacterial biologist and geneticist who joins the Institute after completing a postdoctoral fellowship at Princeton University. Keywords: Bacteria; Biochemistry; Cells; Chemistry; Neurons; Stowers Institute for Medical Research; Technology EN Bacteria Biochemistry Cells Chemistry Neurons Stowers Institute for Medical Research Technology 3603 3603 1 05/15/23 20230519 NES 230519 2023 MAY 19 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- KANSAS CITY, MO--The Stowers Institute for Medical Research announced the hiring of three principal investigators to further expand its team of scientists who seek to answer life's biggest mysteries through foundational research. [Extracted from the article]

Keywords: Aurora; State:Colorado; United States; North and Central America; Chemicals and Chemistry; Blood Cells; Dicarboxylic Acids; Granulocytes; Health and Medicine; Hemic and Immune Systems; Immunology; Neutrophils; Phagocytes; Succinates; Succinic Acid EN Aurora State:Colorado United States North and Central America Chemicals and Chemistry Blood Cells Dicarboxylic Acids Granulocytes Health and Medicine Hemic and Immune Systems Immunology Neutrophils Phagocytes Succinates Succinic Acid 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Chemicals and Chemistry. For more information on this research see: Succinate Activation of Sucnr1 Predisposes Severely Injured Patients To Neutrophil-mediated Ards. [Extracted from the article]