A study conducted at Hubei University in Wuhan, People's Republic of China, explored the use of an "lysosomal bomb" constructed with amorphous calcium carbonate to induce tumor apoptosis through amplified sonodynamic therapy. The research focused on neutralizing the acidic microenvironment of tumors, causing lysosomal dysfunction, and increasing drug accumulation to enhance treatment efficacy. The study demonstrated promising results in vitro and in vivo, suggesting potential applications for tumor inhibition and medical imaging. This research was supported by various funding sources and has been peer-reviewed for accuracy and validity. [Extracted from the article]
Published
2025
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