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Background and Objectives: Employee's perception of spirituality in all aspects of organization management is called "spiritual climate". On the other hand, employees' active presence in the workplace, rather than their mere physical presence, is referred to as "Presenteeism". The current study aimed to localize these variables and study the relationship between them. Methods: This cross-sectional study was conducted on the employees of a car manufacturing company in Tehran, Iran, 2018. In addition to the demographic form, the spiritual climate was assessed using Spiritual Climate Survey (SCS). On the other hand, Stanford Presenteeism scale was implemented to measure work attendance. Among 216 participants, 154 subjects attended work despite musculoskeletal pain, and performed their duties; therefore, they entered the analytical phase. The validity and reliability of the instruments and relationship analysis were performed by Partial Least Squares path modeling method. Results: The results of validity and reliability tests confirmed the suitability of the instruments. Work presenteeism was reported as 71.2%. The mean spiritual climate score was measured at 58.07±11.38. The mean work presenteeism score was obtained as 17.50±4.66. Pathway of spiritual climate to presenteeism at work is statistically significant. On the other hand, the ratio of the spiritual climate variable to the presenteeism was reported to be significant. Moreover, the ratio of spiritual climate to presenteeism indicated that 17.5% of presenteeism alterations were ascribed to the spiritual climate. Conclusion: The Persian versions of the SCS and Stanford Presenteeism questionnaire can be applied as new and valid measurement instruments. In addition, it was found that the spiritual climate in organizations is one of the variables that can positively affect employees' health, as well as work presenteeism, and increase organizational productivity. [ABSTRACT FROM AUTHOR]