1. Recurrent oral cavity cancer: Patterns of failure after salvage multimodality therapy
- Author
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Sean R, Quinlan-Davidson, William H, Morrison, Jeffrey N, Myers, Gary B, Gunn, William N, William, Beth M, Beadle, Heath D, Skinner, Ann M, Gillenwater, Steven J, Frank, Jack, Phan, Faye M, Johnson, Clifton D, Fuller, Mark E, Zafereo, David I, Rosenthal, and Adam S, Garden
- Subjects
Adult ,Aged, 80 and over ,Male ,Salvage Therapy ,Kaplan-Meier Estimate ,Middle Aged ,Prognosis ,Combined Modality Therapy ,Risk Assessment ,Survival Analysis ,Disease-Free Survival ,Cohort Studies ,Young Adult ,Logistic Models ,Treatment Outcome ,Antineoplastic Combined Chemotherapy Protocols ,Carcinoma, Squamous Cell ,Humans ,Female ,Mouth Neoplasms ,Radiotherapy, Intensity-Modulated ,Neoplasm Recurrence, Local ,Aged ,Retrospective Studies - Abstract
We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy.A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed.Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy. Five-year overall survival, recurrence-free survival, and locoregional control rates were 59%, 60%, and 74%, respectively.Outcomes of radiation naïve patients with recurrent OCC are fair, and seem similar with patients with locally advanced nonrecurrent OCC treated with multimodal therapy. © 2016 Wiley Periodicals, Inc. Head Neck 39: 633-638, 2017.
- Published
- 2016