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The article offers information on the relationship between mental health and migraine outcomes in children and adolescents. Topics include the 2019 joint guidelines on the preventive treatment of migraine in this population, a prospective study questioning the association between anxiety/depression and migraine outcomes, and the limitations of previous literature in supporting clinical beliefs and guidelines.

The article presents the discussion on behavioral treatments working for migraine prevention. Topics include providing separate estimates for each dose and route of administration of each triptan; resulting from progressive muscle relaxation, autogenic training, behavioral management, cognitive behavioral therapy (CBT), biofeedback, mindfulness-based interventions, and hypnosis; and cognitive behavioral therapies leading to reductions in attacking frequency and disability.

The author reflects on the treatments for headache, including migraine, in the emergency department (ED). Other topics include how non-headache specialists in the ED should treat headache like screening for secondary headache, as well as the various factors affecting acute treatment of migraine like length of attack, severity of migraine, and the presence of other symptoms like allodynia.

An introduction is presented in which the editor discusses articles in the issue on topics including acute treatment of migraine attacks, use of target calcitonin gene-related peptide (CGRP) for migraine, and clinical trials of 5HT-1F receptor agonists.