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Your search keyword '"Kristian Ikenberg"' showing total 2 results
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2 results on '"Kristian Ikenberg"'

1. Preoperative assessment of CD44‐mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma

Author

Grégoire B. Morand, Isabel Cardona, Kristian Ikenberg, Domenic Vital, Holger Moch, Sandro J. Stoeckli, Gerhard F. Huber, University of Zurich, and Morand, Grégoire B

Subjects
Male, 0301 basic medicine, 10045 Clinic for Otorhinolaryngology, Kaplan-Meier Estimate, Hospitals, University, 0302 clinical medicine, Prospective Studies, biology, medicine.diagnostic_test, Middle Aged, Magnetic Resonance Imaging, humanities, Gene Expression Regulation, Neoplastic, 2733 Otorhinolaryngology, Hyaluronan Receptors, Treatment Outcome, Depth of invasion, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Biomarker (medicine), Mouth Neoplasms, Radiology, Switzerland, Adult, medicine.medical_specialty, Epithelial-Mesenchymal Transition, Sentinel lymph node, 610 Medicine & health, Risk Assessment, 03 medical and health sciences, Predictive Value of Tests, 10049 Institute of Pathology and Molecular Pathology, Preoperative Care, Biopsy, Carcinoma, medicine, Humans, Neoplasm Invasiveness, Aged, Neoplasm Staging, Retrospective Studies, Sentinel Lymph Node Biopsy, business.industry, CD44, Cancer, medicine.disease, Survival Analysis, Occult, Logistic Models, 030104 developmental biology, Otorhinolaryngology, Multivariate Analysis, biology.protein, Tomography, X-Ray Computed, business
Abstract

BACKGROUND Epithelial-mesenchymal transition and cancer stem-like cells (CSC) have been linked to increased metastatic potential. We evaluated the prognostic impact of CD44, a CSC biomarker, on depth of invasion (DOI) and outcome in oral squamous cell carcinoma (OSCC). METHODS Using a multivariable logistic regression model, we evaluated in early OSCCs the relationship between CD44 expression at the invasive tumor front, DOI, sentinel lymph node biopsy, extension of nodal involvement, and survival. We also assessed whether CT and/or MRI could predict DOI preoperatively. RESULTS CD44 expression was associated with increased DOI (P = .018), worse disease-specific survival (P = .041) but not with positive sentinel lymph node biopsy (P > .05). Each millimeter increase in DOI was associated with a 31.1% higher risk for positive sentinel lymph node biopsy (95% CI: 5.8%-62.4%, P = .013) and with higher metastatic ratio (P = .015). Preoperative estimation of DOI by CT and/or MRI and histopathological DOI showed a strong correlation (P

Published
2018

2. p16INK4a: A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule

Author

Domenic Vital, Michael B. Soyka, David Holzmann, Dieter R. Zimmermann, Gerhard F. Huber, Holger Moch, and Kristian Ikenberg

Subjects
0301 basic medicine, Nasal cavity, Pathology, medicine.medical_specialty, biology, business.industry, Surrogate endpoint, Incidence (epidemiology), HPV infection, Retrospective cohort study, biology.organism_classification, medicine.disease, Nose neoplasm, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, medicine, Nasal vestibule, Papillomaviridae, business, neoplasms
Abstract

Background The purpose of this study was to analyze the role of p16INK4a and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule. Methods Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16INK4a and HPV-DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16INK4a positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%-69% was considered to be a “borderline” result. Results There were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16INK4a and 30 (65.2%) for analysis of HPV. Expression of p16INK4a was present in 19.4% and showed coincidence with high-risk HPV (P < .001). Neither p16INK4a nor HPV-DNA had significant impact on outcome. Conclusion Significant immunoreactivity for p16INK4a was present in about one-fifth of the samples and figured as a surrogate marker of high-risk HPV infection. There was no influence on outcome.

Published
2017

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